Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Arthur E. Broadus"'
Publikováno v:
Bone. 81:104-111
Parathyroid hormone-related protein (PTHrP) is widely expressed in the fibrous outer layer of the periosteum (PO), and the PTH/PTHrP type I receptor (PTHR1) is expressed in the inner PO cambial layer. The cambial layer gives rise to the PO osteoblast
Publikováno v:
Journal of Bone and Mineral Research. 28:598-607
The sites that receive ligament and tendon insertions (entheses) on the cortical surfaces of long bones are poorly understood, particularly as regards modeling and regulation. Entheses are classified as either fibrocartilagenous or fibrous based on t
Publikováno v:
Arthritis & Rheumatism. 63:3333-3343
Hyaline chondrocytes throughout the body must remain in their native undifferentiated state in order to function. Virtually all such cells, including articular chondrocytes, seem to have the capacity to progress through the chondrocyte differentiatio
Autor:
Andrew F. Stewart, Arthur E. Broadus, Karl L. Insogna, Eleanor C. Weir, Terence Wu, William J. Burtis
Publikováno v:
Journal of Bone and Mineral Research. 2:37-43
Three bioassays are widely employed for the measurement of PTH-like adenylate cyclase-stimulating factors (ACSFs) drived from tumors associated with humoral hypercalcemia of malignancy. These include renal cortical adenylate cyclase (RAC) assays, rat
Publikováno v:
Journal of Neurochemistry. 62:1239-1246
The parathyroid hormone-related peptide (PTHrP) gene has been reported to be subject to a wide variety of physiological and pharmacological controls. Two distinct patterns of PTHrP mRNA response have been recognized, one characterized by a prolonged
Publikováno v:
Annals of the New York Academy of Sciences. 1116:65-81
PTHrP gene-expression products are generally of very low abundance. The PTHrP-lacZ knockin mouse is a useful tool in this regard, identifying PTHrP expression in previously unrecognized sites and serving to score this expression in gene-regulation ex
Autor:
Xuesong Chen, Vicki E. Hammond, Carolyn M. Macica, Julie R. Hens, Arthur E. Broadus, Barbara E. Dreyer, William M. Philbrick
Publikováno v:
Journal of Bone and Mineral Research. 21:113-123
The PTHrP gene generates low-abundance mRNA and protein products that are not easily localized by in situ hybridization histochemistry or immunohistochemistry. We report here a PTHrP-lacZ knockin mouse in which β-gal activity seems to provide a simp
Publikováno v:
Journal of Bone and Mineral Research. 20:1454-1461
Mechanical forces play a critical role in regulating skeletal mass and structure. We report that mechanical loading induces PTHrP in osteoblast-like cells and that TREK-2 stretch-activated potassium channels seem to be involved in this induction. Our