Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Arthur D. Weissman"'
Autor:
Arthur D. Weissman, Scott Perschke, Sandra P. Welch, Thomas C. Rich, James F. Keefer, Richard D. Carliss
Publikováno v:
Pharmacology Biochemistry and Behavior. 92:495-502
Structure-activity relationships built around receptor binding or cell-based assays are designed to reveal physiochemical differences between ligands. We hypothesized that agonist receptor reserve may provide a unique approach to distinguish structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d285df0718b19101053e36cff57c20
https://doi.org/10.1016/j.pbb.2009.01.019
https://doi.org/10.1016/j.pbb.2009.01.019
Sigma-1 andSigma-2 sites in rat brain: Comparison of regional, ontogenetic, and subcellular patterns
Publikováno v:
Synapse. 17:182-189
Radioligand binding assay conditions were established for the selective labeling of sigma-1 and sigma-2 sites in membrane homogenates of rat brain. Selective sigma-1 assays were conducted using 5 nM(+)[3H]SKF-10,047 in the presence of 300 nM dizocilp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba5aee73f60508367754e0e1450779e
https://doi.org/10.1002/syn.890170307
https://doi.org/10.1002/syn.890170307
Publikováno v:
Journal of Neurochemistry. 54:598-604
The phylogenetic distributions of sigma- and phencyclidine receptors in neural tissues of 13 species and the pharmacological characteristics of these receptors in whole sea anemone and neural tissues of the guinea pig, chicken, and frog were studied.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be47a90c8ff91de9219ab51f4cdda08
https://doi.org/10.1111/j.1471-4159.1990.tb01913.x
https://doi.org/10.1111/j.1471-4159.1990.tb01913.x
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 22:372-374
SUMMARY 1. To investigate the long-term changes caused by amphetamines in the developing brain, we used both an in vivo and in vitro model of chronic fetal exposure to methamphetamine and related drugs. 2. Offspring of rats, treated with either salin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac083aadbee1f21ad4d49247dc49dfd
https://doi.org/10.1111/j.1440-1681.1995.tb02022.x
https://doi.org/10.1111/j.1440-1681.1995.tb02022.x
Publikováno v:
European journal of pharmacology. 250(2)
Binding sites for the sigma ligand [3H]di-o-tollylguanidine ([3H]DTG) have been reported to be altered in the brains of genetically dystonic rats. In the present study, selective sigma 1 and sigma 2 assay conditions were utilized in an effort to defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39deb4dc83973bc993766549c4f7ced0
https://pubmed.ncbi.nlm.nih.gov/8112390
https://pubmed.ncbi.nlm.nih.gov/8112390
Publikováno v:
Synapse (New York, N.Y.). 13(3)
Chronic in utero methamphetamine treatment, throughout gestation in rats, resulted in alterations in both behavior and brain monoamine function in the adult offspring. The higher dose of methamphetamine (10 mg/kg/b.i.d.) caused a significant decrease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed7065efe95333f5e2ac2045ca54ca8
https://pubmed.ncbi.nlm.nih.gov/8497809
https://pubmed.ncbi.nlm.nih.gov/8497809
Autor:
Manuel F. Casanova, Arthur D. Weissman, Joel E. Kleinman, Edythe D. London, Errol B. De Souza
Publikováno v:
Biological psychiatry. 29(1)
Drugs such as phencyclidine (PCP) that interact with PCP and sigma binding sites can produce psychotomimetic effects that resemble some symptoms of schizophrenia. Therefore, it has been suggested that PCP and sigma receptors may be important in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859f6cd989b11be1d8e4016e2067f339
https://pubmed.ncbi.nlm.nih.gov/1848113
https://pubmed.ncbi.nlm.nih.gov/1848113
Autor:
Eric L. Schwartz, Arthur D. Weissman
Publikováno v:
Brain Research Bulletin. 6:543-546
The construction of a high density multi-channel fluid potential electrode array is described. The resulting electrode array which is flat, flexible and non-irritating, is designed for long-term chronic implantation over cortical surfaces of compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a92e7462d2efdfb28be2cbcb54a780f
https://doi.org/10.1016/s0361-9230(81)80029-9
https://doi.org/10.1016/s0361-9230(81)80029-9
Autor:
John E. Johnson, Arthur D. Weissman
Publikováno v:
Brain Research Bulletin. 20:39-47
neuroglioblastoma cells were grown in culture medium containing either 10−3, 10−6 or 10−9 M cocaine for 1–3 days. Some cultures were assessed for viability while others were processed for electron microscopy. Following 1–3 days of cocaine,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ce9232f2e969c51a030769ee65e9d3
https://doi.org/10.1016/0361-9230(88)90007-x
https://doi.org/10.1016/0361-9230(88)90007-x
Publikováno v:
Brain Research. 435:29-40
The effects of phencyclidine (PCP; 0.5, 1.5, 10 mg/kg, i.v.) on local cerebral glucose utilization (LCGU) in the rat were studied with the 2-deoxy- d -[1- 14 C]glucose method. Significant findings were obtained in 41 of 87 brain regions of PCP-treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f83c7bc8ec999a9a79705196061351
https://doi.org/10.1016/0006-8993(87)91583-6
https://doi.org/10.1016/0006-8993(87)91583-6