Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Arthur D. Riggs"'
Autor:
Guihua Sun, Qi Cui, Gustavo Garcia, Elizabeth M. Lizhar, Vaithilingaraja Arumugaswami, Yanhong Shi, Arthur D. Riggs
Publikováno v:
Microbiology Research, Vol 13, Iss 4, Pp 788-808 (2022)
After two years into the pandemic of the coronavirus disease 2019 (COVID-19), it remains unclear how the host RNA interference (RNAi) pathway and host miRNAs regulate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and impact t
Externí odkaz:
https://doaj.org/article/89023e9f76354f5086a76a5ad36c4835
Autor:
Eryun Zhang, Lihua Jin, Yangmeng Wang, Jui Tu, Ruirong Zheng, Lili Ding, Zhipeng Fang, Mingjie Fan, Ismail Al-Abdullah, Rama Natarajan, Ke Ma, Zhengtao Wang, Arthur D. Riggs, Sarah C. Shuck, Li Yang, Wendong Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Mammalian 5′-AMP-activated protein kinase (AMPK) is a nutrient sensor and a therapeutic target for Type 2 Diabetes. Here the authors report that intestinal AMPK modulates brown adipose tissue thermogenesis through anti-microbial peptide controlled
Externí odkaz:
https://doaj.org/article/485d44f0baf04706b6b2590153a90ce8
Autor:
Guihua Sun, Qi Cui, Gustavo Garcia, Cheng Wang, Mingzi Zhang, Vaithilingaraja Arumugaswami, Arthur D. Riggs, Yanhong Shi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The transcriptome of SARS-CoV-2-infected cells that reflects the interplay between host and virus has provided valuable insights into mechanisms underlying SARS-CoV-2 infection and COVID-19 disease progression. In this study, we show that SA
Externí odkaz:
https://doaj.org/article/0f087bf8808a4cf993b837bd93dab18a
Autor:
Jianfei Chao, Lizhao Feng, Peng Ye, Xianwei Chen, Qi Cui, Guihua Sun, Tao Zhou, E Tian, Wendong Li, Weidong Hu, Arthur D. Riggs, Reuben Matalon, Yanhong Shi
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104391- (2022)
Summary: Canavan disease (CD) is a devastating neurological disease that lacks effective therapy. Because CD is caused by mutations of the aspartoacylase (ASPA) gene, we introduced the wild-type (WT) ASPA gene into patient iPSCs through lentiviral tr
Externí odkaz:
https://doaj.org/article/ec108dc0d5d644b9b0f6d2a356457de6
Autor:
Guihua Sun, Meirigeng Qi, Alexis S. Kim, Elizabeth M. Lizhar, Olivia W. Sun, Ismail H. Al-Abdullah, Arthur D. Riggs
Publikováno v:
Non-Coding RNA, Vol 9, Iss 2, p 20 (2023)
miRNAs are critical for pancreas development and function. However, we found that there are discrepancies regarding pancreatic miRNA abundance in published datasets. To obtain a more relevant profile that is closer to the true profile, we profiled sm
Externí odkaz:
https://doaj.org/article/01f635858bac481a8ad6d4e1bf975e09
Autor:
Qingxiao Song, Xiaoning Wang, Xiwei Wu, Tae Hyuk Kang, Hanjun Qin, Dongchang Zhao, Robert R. Jenq, Marcel R. M. van den Brink, Arthur D. Riggs, Paul J. Martin, Yuan-Zhong Chen, Defu Zeng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Pathogenesis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) remains unclear., Here the authors show in mouse models that dysbiosis caused by the expansion of Th/Tc22, as well as depletion of CX3CR1hi mononuclear phagocytes re
Externí odkaz:
https://doaj.org/article/c8534a9423bb4707be4f40f6e27c3f2e
Autor:
Adam. E. Richardson, Zachary. A. Zentz, Antonio E. Chambers, Siara N. Sandwith, Michael A. Reisinger, Destinee W. Saunders, Joshua D. Tompkins, Arthur D. Riggs, Eric D. Routh, Eric M. Rubenstein, Melissa A. Smaldino, James P. Vaughn, Robert A. Haney, Philip J. Smaldino
Publikováno v:
ACS Omega, Vol 5, Iss 38, Pp 24916-24926 (2020)
Externí odkaz:
https://doaj.org/article/3e864a15bddf436ab2a010b8f3d9be8d
Autor:
Fouad Kandeel MD, PhD, Mohamed El-Shahawy MD, MHA, MPH, Gagandeep Singh MD, Donald C. Dafoe MD, Jeffrey S. Isenberg MD, MPH, Arthur D. Riggs PhD
Publikováno v:
Cell Transplantation, Vol 30 (2021)
Allocation of donated organs for transplantation is a complex process that considers numerous factors such as donor, organ and candidate characteristics and practical issues such as geography. Whole pancreas and isolated islet transplantation are lif
Externí odkaz:
https://doaj.org/article/1c88b2f1d5ea4ef48a8bbf7915503db0
Publikováno v:
BMC Genomics, Vol 18, Iss S6, Pp 9-17 (2017)
Abstract Background Research interests toward single cell analysis have greatly increased in basic, translational and clinical research areas recently, as advances in whole-transcriptome amplification technique allow scientists to get accurate sequen
Externí odkaz:
https://doaj.org/article/5974dd765a4844d98ae7a8a3465c24db
Autor:
Guihua Sun, Arthur D. Riggs
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss , Pp 345-355 (2017)
We have studied the molecular properties of in-vitro-transcribed sliced small interfering RNAs (tsli-siRNAs) as an alternative RNAi agent for chemically synthesized siRNA. We describe here a simple and cost-effective procedure for high-purity product
Externí odkaz:
https://doaj.org/article/ead99974bc3a4192b60f117ea40f6904