Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Arthur D. Patten"'
1
Screening-based discovery of the first novel ATP competitive inhibitors of the Staphylococcus aureus essential enzyme UMP kinase
Autor: Ning Gao, Tory J. Nash, Peter Doig, Carolyn Blackett, Elise Gorseth, Arthur D. Patten
Publikováno v: Biochemical and Biophysical Research Communications. 437:162-167
UMP kinase (PyrH) is an essential enzyme found only in bacteria, making it ideal as a target for the discovery of antibacterials. To identify inhibitors of PyrH, an assay employing Staphylococcus aureus PyrH coupled to pyruvate kinase/lactate dehydro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a3e3ac8c6b768f1212eab43ce88a9f
https://doi.org/10.1016/j.bbrc.2013.06.060
Zobrazit plný text záznamu
2
An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode
Autor: P. Ann Boriack-Sjodin, Tory J. Nash, Carolyn Blackett, Peter Doig, Arthur D. Patten, Adam B. Shapiro, Camil Joubran, Marshall Morningstar, Nicholas A. Larsen
Publikováno v: The Biochemical journal. 446(3)
GlmU is a bifunctional enzyme with acetyltransferase and uridyltransferase activities, and is essential for the biosynthesis of the bacterial cell wall. Inhibition results in a loss of cell viability. GlmU is therefore considered a potential target f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f33dce93ece1f8595c862e549e28514
https://pubmed.ncbi.nlm.nih.gov/22721802
Zobrazit plný text záznamu
3
Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series
Autor: Oluyinka Green, Haihong Ni, Arthur D. Patten, Sameer Kawatkar, Robert Albert, Jason Breed, Suzanne Stokes, Ludovic Otterbein, Andrew R. McKenzie, Adam B. Shapiro
Publikováno v: Bioorganicmedicinal chemistry letters. 22(4)
A novel arylsulfonamide-containing series of compounds represented by 1, discovered by highthroughput screening, inhibit the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c719b54c25811e97fb3d60a72fe33bd
https://pubmed.ncbi.nlm.nih.gov/22297115
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje