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pro vyhledávání: '"Arthur Bank"'
Autor:
Arthur Bank
This book describes the life and times of a physician-scientist over the last half-century. Part One is about the author's struggle with colon cancer and the lessons he learnt from the experience; Part Two is about his life growing up, the pretzel ba
Autor:
Arthur Bank
Publikováno v:
Hematology/Oncology Clinics of North America. 24:1187-1201
Allogeneic stem cell transplantation currently is the only curative option for severe β-thalassemia and sickle cell disease. Human globin gene therapy with autotransplantation of transduced human hematopoietic stem cells is an exciting alternative a
Publikováno v:
Scandinavian Journal of Haematology. 7:465-470
Longevity in patients with well-documented homozygous β thalassaemia is quite uncommon. This report describes a family with two brothers with β thalassaemia of intermediate severity who lived until ages 34 and 51. The older sibling had a haemoglobi
Autor:
Arthur Bank
Publikováno v:
Pediatric Hematology and Oncology. 25:1-4
Human globin gene therapy is a potential cure for sickle cell disease and beta-thalassemia (Cooley anemia). A clinical trial of this treatment is currently under way in Paris using lentiglobin vectors.
Autor:
Arthur Bank
Publikováno v:
Journal of Clinical Investigation. 117:1746-1749
Normal human hemoglobin (Hb) formation and function is one of the marvels of human evolution and the process of natural selection. Get it right and you have the best functional molecule ever known to pick up oxygen in the lungs and deliver it to need
Autor:
Arthur Bank
Publikováno v:
Blood. 107:435-443
The human globin genes are among the most extensively characterized in the human genome, yet the details of the molecular events regulating normal human hemoglobin switching and the potential reactivation of fetal hemoglobin in adult hematopoietic ce
Publikováno v:
Annals of the New York Academy of Sciences. 1054:308-316
Recent success in the long-term correction of mouse models of human beta-thalassemia and sickle cell anemia by lentiviral vectors and evidence of high gene transfer and expression in transduced human hematopoietic cells have led to a first clinical t
Autor:
Engracio P Cortes, James F Holland, Jaw J Wang, Lucius F Sinks, Johannes Blom, Hansjurg Senn, Arthur Bank, Oliver Glidewell, Henry H Sherk
Publikováno v:
Clinical Orthopaedics and Related Research. :5-8
Autor:
Arthur Bank
Publikováno v:
Journal of Clinical Investigation. 115:1470-1473
A vast excess of α-globin production and inadequate γ-globin compensation lead to the development of severe anemia in human β-thalassemia. Newly identified modifiers of α- and γ-globin synthesis and insights into the mechanisms of globin regulat
Autor:
Rocio Lopez, Dianne Pulte, Maureen Ward, Christine Richardson, David O'Neill, Arthur Bank, Shane T. Baker, Ellen K. Ritchie
Publikováno v:
American Journal of Hematology. 81:12-18
Ikaros is a critical transcriptional regulator of hematopoietic cell differentiation. In addition to its effects on the lymphoid system and hematopoietic stem-cell compartment, we have previously shown that Ikaros is also required for normal erythroi