Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Arthi A. Macpherson"'
Autor:
Wayne A. Phillips, Owen J. Sansom, Patrick O. Humbert, Peter R. Shepherd, Toby J. Phesse, Kaylene J. Simpson, Matthew J. Smalley, Richard W. Clarkson, Carleen Cullinane, Luc Furic, Sarah Koushyar, Arthi A. Macpherson, Richard J. Rebello, Karen G. Montgomery, Paul Waring, Christina M. Fennell, Valerie S. Meniel, Jason Li, Helen B. Pearson
Supplementary Figure 7: Characterization of Pik3ca+/HR, Ptenfl/fl and Pik3ca+/HR;Ptenfl/fl prostate tumors. Representative images of IHC to detect (A) PCNA and (B) Cleaved-caspase 3 (CC3) in Pik3ca+/HR, Ptenfl/fl and Pik3ca+/HR;Ptenfl/fl prostate tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3488fe8b07def2dceebd43715c46b34f
https://doi.org/10.1158/2159-8290.22532960
https://doi.org/10.1158/2159-8290.22532960
Autor:
Wayne A. Phillips, Owen J. Sansom, Patrick O. Humbert, Peter R. Shepherd, Toby J. Phesse, Kaylene J. Simpson, Matthew J. Smalley, Richard W. Clarkson, Carleen Cullinane, Luc Furic, Sarah Koushyar, Arthi A. Macpherson, Richard J. Rebello, Karen G. Montgomery, Paul Waring, Christina M. Fennell, Valerie S. Meniel, Jason Li, Helen B. Pearson
Supplementary Figure 6: Pik3ca+/HR and Ptenfl/fl prostate cancers acquire CRPC, while Pik3ca+/HR;Ptenfl/fl mutants are resistant to castration. (A) Representative H&E images of Pik3ca+/HR, Ptenfl/fl and Pik3ca+/HR;Ptenfl/fl anterior (AP) and ventral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59a48e377372e9ac935445f3759bcc3
https://doi.org/10.1158/2159-8290.22532963.v1
https://doi.org/10.1158/2159-8290.22532963.v1
Autor:
Wayne A. Phillips, Owen J. Sansom, Patrick O. Humbert, Peter R. Shepherd, Toby J. Phesse, Kaylene J. Simpson, Matthew J. Smalley, Richard W. Clarkson, Carleen Cullinane, Luc Furic, Sarah Koushyar, Arthi A. Macpherson, Richard J. Rebello, Karen G. Montgomery, Paul Waring, Christina M. Fennell, Valerie S. Meniel, Jason Li, Helen B. Pearson
Supplementary Figure 3: Characterization of Pik3ca-mutated and Pten-deleted prostate hyperplasia and carcinoma. (A) IHC to detect the apoptotic marker Cleaved-Caspase-3 (CC3) in Wt, Pik3ca+/HR and Ptenfl/fl mice at 400 d (scale bar: 50 um). (B) Quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422b5ffff4f63f727dd06efbd665b2c0
https://doi.org/10.1158/2159-8290.22532972
https://doi.org/10.1158/2159-8290.22532972
Autor:
Wayne A. Phillips, Owen J. Sansom, Patrick O. Humbert, Peter R. Shepherd, Toby J. Phesse, Kaylene J. Simpson, Matthew J. Smalley, Richard W. Clarkson, Carleen Cullinane, Luc Furic, Sarah Koushyar, Arthi A. Macpherson, Richard J. Rebello, Karen G. Montgomery, Paul Waring, Christina M. Fennell, Valerie S. Meniel, Jason Li, Helen B. Pearson
Supplementary Figure 5: Pik3caH1047R mutation and Pten-deletion synergize to promote prostate cancer by increasing mTORC1/2 signaling. Histograms displaying phenotype incidence for anterior (A) and ventral (B) prostate lobes at 56 and 100 days of age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748e126ba30679f534d1981f9914abf4
https://doi.org/10.1158/2159-8290.22532966
https://doi.org/10.1158/2159-8290.22532966
Autor:
Wayne A. Phillips, Owen J. Sansom, Patrick O. Humbert, Peter R. Shepherd, Toby J. Phesse, Kaylene J. Simpson, Matthew J. Smalley, Richard W. Clarkson, Carleen Cullinane, Luc Furic, Sarah Koushyar, Arthi A. Macpherson, Richard J. Rebello, Karen G. Montgomery, Paul Waring, Christina M. Fennell, Valerie S. Meniel, Jason Li, Helen B. Pearson
Supplementary Figure 4: Pik3caH1047R heterozygous oncogenic mutation causes p110alpha-dependent prostate cancer. Representative H&E images (scale bar: 100 um) for Pik3ca+/HR and Ptenfl/fl dorsolateral prostate and histograms displaying phenotype inci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3a19820e356894e2a42a6e1d4ad1bd
https://doi.org/10.1158/2159-8290.22532969
https://doi.org/10.1158/2159-8290.22532969
Autor:
Wayne A. Phillips, Owen J. Sansom, Patrick O. Humbert, Peter R. Shepherd, Toby J. Phesse, Kaylene J. Simpson, Matthew J. Smalley, Richard W. Clarkson, Carleen Cullinane, Luc Furic, Sarah Koushyar, Arthi A. Macpherson, Richard J. Rebello, Karen G. Montgomery, Paul Waring, Christina M. Fennell, Valerie S. Meniel, Jason Li, Helen B. Pearson
Supplementary Figure 2: Heterozygous Pik3caH1047R oncogenic mutation causes invasive prostate cancer in mice that is phenotypically distinct to Pten-null prostate cancer. (A) Sequencing cDNA isolated from PBiCre+/-;Pik3ca+/HR prostate tissue confirme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe6e21a4d38fe4f33e4c2b16ff8131e
https://doi.org/10.1158/2159-8290.22532975.v1
https://doi.org/10.1158/2159-8290.22532975.v1
Autor:
Wayne A. Phillips, Owen J. Sansom, Patrick O. Humbert, Peter R. Shepherd, Toby J. Phesse, Kaylene J. Simpson, Matthew J. Smalley, Richard W. Clarkson, Carleen Cullinane, Luc Furic, Sarah Koushyar, Arthi A. Macpherson, Richard J. Rebello, Karen G. Montgomery, Paul Waring, Christina M. Fennell, Valerie S. Meniel, Jason Li, Helen B. Pearson
Supplementary Figure 1: PIK3CA mutations are predominantly missense mutations and PTEN mutation/loss predicts for poor prostate cancer patient survival. (A) Pie chart depicting the frequency of missense/nonsense mutations, in-frame deletions and fusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426a2d405634f087eb04241301ecf289
https://doi.org/10.1158/2159-8290.22532978.v1
https://doi.org/10.1158/2159-8290.22532978.v1
Autor:
Wayne A. Phillips, Owen J. Sansom, Patrick O. Humbert, Peter R. Shepherd, Toby J. Phesse, Kaylene J. Simpson, Matthew J. Smalley, Richard W. Clarkson, Carleen Cullinane, Luc Furic, Sarah Koushyar, Arthi A. Macpherson, Richard J. Rebello, Karen G. Montgomery, Paul Waring, Christina M. Fennell, Valerie S. Meniel, Jason Li, Helen B. Pearson
Supplemetary Material and Tables S1 - S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578fd7c7f0304b17bda6ca3fb1f6dbfd
https://doi.org/10.1158/2159-8290.22532957
https://doi.org/10.1158/2159-8290.22532957
Autor:
Guy D. Eslick, Cuong Duong, Catherine Mitchell, Wayne A. Phillips, Jovana R. Gotovac, David Shi Hao Liu, Michael Yates, Kaylene J. Simpson, Arthi A. Macpherson, Julia V. Milne, Nicholas J Clemons
Publikováno v:
The Journal of Pathology
Efficacious therapeutic approaches are urgently needed to improve outcomes in patients with oesophageal adenocarcinoma (OAC). However, oncogenic drivers amenable to targeted therapy are limited and their functional characterisation is essential. Amon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6afc6dc370071ecd105fbd84dc55d3
http://europepmc.org/articles/PMC7693356
http://europepmc.org/articles/PMC7693356
Autor:
Richard J. Rebello, Karen G. Montgomery, Peter R. Shepherd, Carleen Cullinane, Toby J. Phesse, Christina M Fennell, Sarah Koushyar, Matthew J. Smalley, Helen B. Pearson, Kaylene J. Simpson, Owen J. Sansom, Wayne A. Phillips, Jason Li, Arthi A. Macpherson, Patrick O. Humbert, Paul Waring, Luc Furic, Valerie Meniel, Richard W. E. Clarkson
Publikováno v:
Cancer Discovery
Genetic alterations that potentiate PI3K signaling are frequent in prostate cancer, yet how different genetic drivers of the PI3K cascade contribute to prostate cancer is unclear. Here, we report PIK3CA mutation/amplification correlates with poor sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169786a0b54d23a24e0a331bdbdc4d6d