Epigenetic regulators of the revascularization response to chronic arterial occlusion

Autor: Joshua L. Heuslein, Catherine M. Gorick, Richard J. Price

Publikováno v: Cardiovascular Research. 115:701-712

Peripheral arterial disease (PAD) is the leading cause of lower limb amputation and estimated to affect over 202 million people worldwide. PAD is caused by atherosclerotic lesions that occlude large arteries in the lower limbs, leading to insufficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06601fcbcb2ed7f131339d47c74e0dc8
https://doi.org/10.1093/cvr/cvz001

Coronary microvascular dysfunction results in impaired coronary flow reserve and altered oxygen balance in a swine model of INOCA with multiple risk factors

Autor: Oana Sorop, Daphne Merkus, Dirk J. Duncker, R.W.A. van Drie, J Van De Wouw, Marianne C. Verhaar, Jaap A. Joles

Publikováno v: European Heart Journal. 41

Introduction Comorbidities of ischemic heart disease, including diabetes mellitus (DM), hypercholesterolemia and chronic kidney disease (CKD), are associated with coronary microvascular dysfunction (CMD) and may contribute to myocardial “Ischemia a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::941f1cc42ed363ea9954187ddcc8fb7f
https://doi.org/10.1093/ehjci/ehaa946.3781

Pax9 and Gbx2 Interact in the Pharyngeal Endoderm to Control Cardiovascular Development

Autor: Catherine A. Stothard, Deborah J. Henderson, Jürgen E. Schneider, Silvia Mazzotta, Helen M. Phillips, Simon D. Bamforth, Arjun Vyas, Timothy J. Mohun

Publikováno v: Journal of Cardiovascular Development and Disease
Volume 7
Issue 2
Journal of Cardiovascular Development and Disease, Vol 7, Iss 20, p 20 (2020)

The correct formation of the aortic arch arteries depends on a coordinated and regulated gene expression profile within the tissues of the pharyngeal arches. Perturbation of the gene regulatory networks in these tissues results in congenital heart de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afba9fb6150c20681bffb56b0cabd4f

P1508The Coronary Arteriogenesis with combined Heparin and Exercise therapy in chronic refractory Angina (CARHEXA) trial: a double-blind randomized placebo-controlled stress echocardiographic study

Autor: A Mladenovic, Vukcevic, Cvetic, Nikola Boskovic, Giga, Eugenio Picano, Jelena Stepanovic, Biljana Beleslin, Ana Djordjevic-Dikic, S Aleksadric, M T Petrovic, M Ostojic, Z Markovic, Dimitra Kalimanovska-Ostric, O Radmili

Publikováno v: European Heart Journal. 40

Background Coronary collateral circulation exerts protective effects on myocardial ischemia due to coronary artery disease (CAD) and can be promoted by exercise (E) with heparin (H) co-administration. Whether this arteriogenetic effects is accompanie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01dc2c16eb1978e1a7dfe56b6a000a6a
https://doi.org/10.1093/eurheartj/ehz748.0270

PDGF signaling from pharyngeal pouches promotes arch artery morphogenesis

Autor: Mingming Zhang, Aihua Mao, Jie Liu, Qiang Wang, Yu Cao

Publikováno v: Journal of genetics and genomics = Yi chuan xue bao. 46(12)

The great vessels of the heart originate from the pharyngeal arch arteries (PAAs). Anomalies of the PAAs often occur together with pharyngeal pouch malformations, but the reasons for this phenomenon are not fully understood. In the current study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948387fe418c2f4bda17da9cee5753ff
https://pubmed.ncbi.nlm.nih.gov/31974005