Therapeutic activity of lipoxin A 4 in TiO 2 -induced arthritis in mice: NF-κB and Nrf2 in synovial fluid leukocytes and neuronal TRPV1 mechanisms.

Autor: Saraiva-Santos T; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil.; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States., Zaninelli TH; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil.; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.; Vascular Biology Program, Department of Surgery, Boston Children's Hospital-Harvard Medical School, Boston, MA, United States., Manchope MF; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Andrade KC; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Ferraz CR; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Bertozzi MM; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Artero NA; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Franciosi A; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Badaro-Garcia S; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Staurengo-Ferrari L; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil., Borghi SM; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil.; Center for Research in Health Sciences, University of Northern Paraná, Londrina, Paraná, Brazil., Ceravolo GS; Department of Physiological Sciences, Center for Biological Sciences, Londrina State University, Londrina, Paraná, Brazil., Andrello AC; Department of Physics, Londrina State University, Londrina, Paraná, Brazil., Zanoveli JM; Department of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba, Parana, Brazil., Rogers MS; Vascular Biology Program, Department of Surgery, Boston Children's Hospital-Harvard Medical School, Boston, MA, United States., Casagrande R; Department of Pharmaceutical Sciences, Centre of Health Sciences, Londrina State University, Londrina, Paraná, Brazil., Pinho-Ribeiro FA; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States., Verri WA Jr; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Jun 14; Vol. 14, pp. 949407. Date of Electronic Publication: 2023 Jun 14 (Print Publication: 2023).

RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice.

Autor: Zaninelli TH; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil., Fattori V; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.; Vascular Biology Program, Department of Surgery, Boston Children's Hospital-Harvard Medical School, Boston, Massachusetts, USA., Saraiva-Santos T; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil., Badaro-Garcia S; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil., Staurengo-Ferrari L; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil., Andrade KC; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil., Artero NA; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil., Ferraz CR; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil., Bertozzi MM; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil., Rasquel-Oliveira F; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil., Manchope MF; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil., Amaral FA; Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Brazil., Teixeira MM; Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Brazil., Borghi SM; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil., Rogers MS; Vascular Biology Program, Department of Surgery, Boston Children's Hospital-Harvard Medical School, Boston, Massachusetts, USA., Casagrande R; Laboratory of Antioxidants and Inflammation, Department of Pharmaceutical Sciences, Centre of Health Sciences, Londrina State University, Londrina, Paraná, Brazil., Verri WA Jr; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2022 Sep; Vol. 179 (18), pp. 4500-4515. Date of Electronic Publication: 2022 Jul 07.

Hesperidin methyl chalcone interacts with NFκB Ser276 and inhibits zymosan-induced joint pain and inflammation, and RAW 264.7 macrophage activation.

Autor: Rasquel-Oliveira FS; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Manchope MF; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Staurengo-Ferrari L; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Ferraz CR; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Saraiva-Santos T; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Zaninelli TH; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Fattori V; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Artero NA; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., Badaro-Garcia S; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil., de Freitas A; Departament of Physiological Sciences, Centre of Biological Sciences, Londrina State University, Londrina, PR, Brazil., Casagrande R; Departament of Pharmaceutical Sciences, Centre of Health Sciences, Londrina State University, Londrina, PR, Brazil., Verri WA Jr; Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, PR, Brazil. waldiceujr@yahoo.com.br.; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid PR 445, KM 380, PO Box 10.011, Londrina, Parana, 86057-970, Brazil. waldiceujr@yahoo.com.br.

Publikováno v: Inflammopharmacology [Inflammopharmacology] 2020 Aug; Vol. 28 (4), pp. 979-992. Date of Electronic Publication: 2020 Feb 11.

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development.

Autor: Ferraz CR; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil., Carvalho TT; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil., Manchope MF; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil., Artero NA; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil., Rasquel-Oliveira FS; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil., Fattori V; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil., Casagrande R; Departament of Pharmaceutical Sciences, Center of Health Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil., Verri WA Jr; Departament of Pathology, Center of Biological Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2020 Feb 10; Vol. 25 (3). Date of Electronic Publication: 2020 Feb 10.

Naringenin mitigates titanium dioxide (TiO 2 )-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB.

Autor: Manchope MF; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid Km480 PR445, Cx Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil., Artero NA; Departamento de Ciências Farmacêuticas, Centro de Ciências de Saúde, Universidade Estadual de Londrina, Londrina, Brazil., Fattori V; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid Km480 PR445, Cx Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil., Mizokami SS; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid Km480 PR445, Cx Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil., Pitol DL; Departamento de Morfologia, Fisiologia e Patologia Básica, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil., Issa JPM; Departamento de Morfologia, Fisiologia e Patologia Básica, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil., Fukada SY; Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil., Cunha TM; Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil., Alves-Filho JC; Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil., Cunha FQ; Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil., Casagrande R; Departamento de Ciências Farmacêuticas, Centro de Ciências de Saúde, Universidade Estadual de Londrina, Londrina, Brazil., Verri WA Jr; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid Km480 PR445, Cx Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil. waverri@uel.br.

Publikováno v: Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2018 Dec; Vol. 67 (11-12), pp. 997-1012. Date of Electronic Publication: 2018 Oct 28.