Výsledky vyhledávání - "Artem Kononenko"

Akademický článek

Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition

Autor: Oladapo O. Yeku, Thapi Dharma Rao, Ian Laster, Artem Kononenko, Terence J. Purdon, Pei Wang, Ziyou Cui, Hong Liu, Renier J. Brentjens, David Spriggs

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Immunotherapy for ovarian cancer is an area of intense investigation since the majority of women with relapsed disease develop resistance to conventional cytotoxic therapy. The paucity of safe and validated target antigens has limited the development

Externí odkaz: https://doaj.org/article/c69c86752324461ebdf6e2f62d642009

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Multivalent Pattern Recognition through Control of Nano-Spacing in Low-Valency Super-Selective Materials

Autor: Hale Bila, Kaltrina Paloja, Vincenzo Caroprese, Artem Kononenko, Maartje M.C. Bastings

Publikováno v: Journal of the American Chemical Society. 144:21576-21586

Super-selective multivalent ligand-receptor interactions display a signature step-like onset in binding when meeting a characteristic density of target receptors. Materials engineered for super-selective binding generally display a high number of fle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5216d04f2f11ad1d52df6a1f53701b1a
https://doi.org/10.1021/jacs.2c08529

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Abstract 2438: Loss of galectin 3 reveals its potential roles in the aggressive pathology of uterine serous carcinoma

Autor: Yusuke Matoba, Dominique T. Zarrella, Venkatesh Pooladanda, Eugene Kim, Shaan Kumar, Mengyao Xu, Xingping Qin, Raj Kumar, Artem Kononenko, Irva Veillard, Kristopher Sarosiek, Oladapo Yeku, David R. Spriggs, Bo R. Rueda

Publikováno v: Cancer Research. 83:2438-2438

Objective: Uterine serous cancer (USC) represents about 10% of all uterine cancers, yet it accounts for up to 40% of all uterine cancer deaths. This lethality is due in part to the highly aggressive clinical course of this disease. Recently, galectin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4a30dd5db1818786439177a55233113
https://doi.org/10.1158/1538-7445.am2023-2438

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Abstract 1837: A human artificial chromosome (HAC)-based system as a powerful tool for stable co-expression of multiple proteins and therapeutic IgGs in mammalian cells

Autor: David R. Spriggs, Artem Kononenko, Ian Laster, Oladapo Yeku

Publikováno v: Cancer Research. 81:1837-1837

Background: Currently, there is increasing demand for recombinant therapeutic proteins produced in mammalian cell lines, especially therapeutic antibodies. MUC16-directed IgG and bispecific diabodies are one such example that represents a promising s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c54b11ab2c0856a7298242280d607de
https://doi.org/10.1158/1538-7445.am2021-1837

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