Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Artem I. Fokin"'
Autor:
Karina D. Rysenkova, Julia Gaboriaud, Artem I. Fokin, Raphaëlle Toubiana, Alexandre Bense, Camil Mirdass, Mélissa Jin, Minh Chau N. Ho, Elizabeth Glading, Sophie Vacher, Laura Courtois, Ivan Bièche, Alexis M. Gautreau
Publikováno v:
Cells, Vol 13, Iss 10, p 876 (2024)
Breast cancer develops upon sequential acquisition of driver mutations in mammary epithelial cells; however, how these mutations collaborate to transform normal cells remains unclear in most cases. We aimed to reconstitute this process in a particula
Externí odkaz:
https://doaj.org/article/05fe3e22aa2c4c49b708a8d10c872ace
Autor:
Artem I. Fokin, Roman N. Chuprov-Netochin, Alexander S. Malyshev, Stéphane Romero, Marina N. Semenova, Leonid D. Konyushkin, Sergey V. Leonov, Victor V. Semenov, Alexis M. Gautreau
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Branched actin networks polymerized by the Actin-related protein 2 and 3 (Arp2/3) complex play key roles in force generation and membrane remodeling. These networks are particularly important for cell migration, where they drive membrane protrusions
Externí odkaz:
https://doaj.org/article/bcbf0001405b4855b2adee551bb48ce7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 16178 (2022)
Membrane trafficking in interphase animal cells is accomplished mostly along the microtubules. Microtubules are often organized radially by the microtubule-organizing center to coordinate intracellular transport. Along with the centrosome, the Golgi
Externí odkaz:
https://doaj.org/article/4addb9830a8c49f987df4cf3c3b7e731
Autor:
Ali Dayoub, Artem I. Fokin, Maria E. Lomakina, John James, Marina Plays, Tom Jacquin, Nikita M. Novikov, Rostislav S. Vorobyov, Anastasia A. Schegoleva, Karina D. Rysenkova, Julia Gaboriaud, Sergey V. Leonov, Evgeny V. Denisov, Alexis M. Gautreau, Antonina Y. Alexandrova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 313 (2022)
Whole exome sequencing of invasive mammary carcinomas revealed the association of mutations in PTEN and ZFHX3 tumor suppressor genes (TSGs). We generated single and combined PTEN and ZFHX3 knock-outs (KOs) in the immortalized mammary epithelial cell
Externí odkaz:
https://doaj.org/article/19d9b678c32a4a019750a399e9b920ac
Autor:
Artem I. Fokin, Alexis M. Gautreau
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The Arp2/3 complex generates branched actin networks at different locations of the cell. The WASH and WAVE Nucleation Promoting Factors (NPFs) activate the Arp2/3 complex at the surface of endosomes or at the cell cortex, respectively. In this review
Externí odkaz:
https://doaj.org/article/3f821438edea4af7aef82351b290169d
Autor:
Gleb Simanov, Irene Dang, Artem I. Fokin, Ksenia Oguievetskaia, Valérie Campanacci, Jacqueline Cherfils, Alexis M. Gautreau
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4115 (2021)
During cell migration, protrusion of the leading edge is driven by the polymerization of Arp2/3-dependent branched actin networks. Migration persistence is negatively regulated by the Arp2/3 inhibitory protein Arpin. To better understand Arpin regula
Externí odkaz:
https://doaj.org/article/4b073e979752431a9ece281f595d9f0d
Autor:
Anna O. Zholudeva, Maria E. Lomakina, Evgeniya A. Orlova, Yanan Wang, Artem I. Fokin, Anna Polesskaya, Alexis M. Gautreau, Antonina Y. Alexandrova
Publikováno v:
Biochemistry (Moscow). 87:1651-1661
Autor:
Artem I. Fokin, Arthur Boutillon, John James, Laura Courtois, Sophie Vacher, Gleb Simanov, Yanan Wang, Anna Polesskaya, Ivan Bièche, Nicolas B. David, Alexis M. Gautreau
The Rac1-WAVE-Arp2/3 pathway pushes the plasma membrane by polymerizing branched actin at the cell cortex and thereby powering membrane protrusions that mediate cell migration. Here, using knock-down (KD) or knock-out (KO), we combine the inactivatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45a4d9bbd288021b029e490dbc74ef1c
https://doi.org/10.1101/2023.05.13.540631
https://doi.org/10.1101/2023.05.13.540631
Autor:
Frédéric Saudou, Emmanuel Derivery, Ksenia Oguievetskaia, Andrew P. Carter, Maria-Victoria Hinckelmann, Nathalie Rocques, Christophe Le Clainche, Guillaume Romet-Lemonne, Véronique Henriot, Nicolas Molinie, Artem I. Fokin, Alexis Gautreau, Violaine David, Luyan Cao, Magali Aumont-Nicaise, Caroline E. Stone
Publikováno v:
Science Advances
Science Advances, 2021, 7 (3), ⟨10.1126/sciadv.abd5956⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2021, ⟨10.1126/sciadv.abd5956⟩
Science Advances, 2021, ⟨10.1126/sciadv.abd5956⟩
Science Advances, 2021, 7 (3), ⟨10.1126/sciadv.abd5956⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2021, ⟨10.1126/sciadv.abd5956⟩
Science Advances, 2021, ⟨10.1126/sciadv.abd5956⟩
Dendritic actin networks grow in an autocatalytic manner starting from the uncapped minifilament of dynactin.
Dendritic actin networks develop from a first actin filament through branching by the Arp2/3 complex. At the surface of endosomes, the
Dendritic actin networks develop from a first actin filament through branching by the Arp2/3 complex. At the surface of endosomes, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbef2378d039c255eb0c8c4302004c93
https://hal.science/hal-03141632
https://hal.science/hal-03141632
Autor:
Arthur Boutillon, Nicolas B. David, Baoyu Chen, Nicolas Molinie, Artem I. Fokin, Anna Polesskaya, Raphael Guerois, Ivan Bièche, Yanan Wang, Marc Lavielle, Stéphane Romero, Sophie Vacher, Anne Schnitzler, Sheng Yang, Yijun Liu, Nathalie Rocques, Alexis Gautreau
Branched actin networks polymerized by the Arp2/3 complex are critical for cell migration. The WAVE complex is the machinery that activates Arp2/3 in a RAC1-dependent manner at the leading edge of migrating cells. Multiple WAVE complexes are assemble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70ffe10544537503f03b917cd662e478
https://doi.org/10.1101/2020.07.02.184655
https://doi.org/10.1101/2020.07.02.184655