Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Artem G Lada"'
Autor:
Artem G Lada, Sergei F Kliver, Alok Dhar, Dmitrii E Polev, Alexey E Masharsky, Igor B Rogozin, Youri I Pavlov
Publikováno v:
PLoS Genetics, Vol 11, Iss 5, p e1005217 (2015)
Mutations in genomes of species are frequently distributed non-randomly, resulting in mutation clusters, including recently discovered kataegis in tumors. DNA editing deaminases play the prominent role in the etiology of these mutations. To gain insi
Externí odkaz:
https://doaj.org/article/f027bcb319a441b8b5279463c2302d46
Autor:
Artem G Lada, Elena I Stepchenkova, Irina S R Waisertreiger, Vladimir N Noskov, Alok Dhar, James D Eudy, Robert J Boissy, Masayuki Hirano, Igor B Rogozin, Youri I Pavlov
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003736 (2013)
Genetic information should be accurately transmitted from cell to cell; conversely, the adaptation in evolution and disease is fueled by mutations. In the case of cancer development, multiple genetic changes happen in somatic diploid cells. Most clas
Externí odkaz:
https://doaj.org/article/4f77e188394c44dea52f2d87780d3510
Autor:
Artem G Lada, Irina S-R Waisertreiger, Corinn E Grabow, Aishwarya Prakash, Gloria E O Borgstahl, Igor B Rogozin, Youri I Pavlov
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24848 (2011)
Editing deaminases have a pivotal role in cellular physiology. A notable member of this superfamily, APOBEC3G (A3G), restricts retroviruses, and Activation Induced Deaminase (AID) generates antibody diversity by localized deamination of cytosines in
Externí odkaz:
https://doaj.org/article/956eb520148d4d4fbb9df5210880a6fb
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7795 (2023)
Baker’s yeast, S. cerevisiae, is an excellent model organism exploited for molecular genetic studies of the mechanisms of genome stability in eukaryotes. Genetic peculiarities of commonly used yeast strains impact the processes of DNA replication,
Externí odkaz:
https://doaj.org/article/c1a46c882c264853aae8bc1cb2c1bc47
Autor:
Igor B. Rogozin, Abiel Roche-Lima, Kathrin Tyryshkin, Kelvin Carrasquillo-Carrión, Artem G. Lada, Lennard Y. Poliakov, Elena Schwartz, Andreu Saura, Vyacheslav Yurchenko, David N. Cooper, Anna R. Panchenko, Youri I. Pavlov
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Cancer genomes harbor numerous genomic alterations and many cancers accumulate thousands of nucleotide sequence variations. A prominent fraction of these mutations arises as a consequence of the off-target activity of DNA/RNA editing cytosine deamina
Externí odkaz:
https://doaj.org/article/f3b49fc35b4a4cddbf7990f7411a0992
Autor:
Anna S. Zhuk, Irina V. Zotova, Youri I. Pavlov, Anna Y. Aksenova, Ivan Ivanovich Kostroma, Artem G. Lada, S.V. Gritsaev, Elena I. Stepchenkova
Publikováno v:
Cancers
Cancers, Vol 13, Iss 5949, p 5949 (2021)
Cancers, Vol 13, Iss 5949, p 5949 (2021)
Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the origin of cancerous cells and the evolution of myeloma disease are not underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680a9229011e8df853a9a6831fabc4b6
https://pubmed.ncbi.nlm.nih.gov/34885058
https://pubmed.ncbi.nlm.nih.gov/34885058
Autor:
David Neil Cooper, Kathrin Tyryshkin, Lennard Y. Poliakov, Artem G. Lada, Youri I. Pavlov, Anna R. Panchenko, Andreu Saura, Kelvin Carrasquillo-Carrión, Igor B. Rogozin, Elena Schwartz, Abiel Roche-Lima, Vyacheslav Yurchenko
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 12 (2021)
Frontiers in Genetics, Vol 12 (2021)
Cancer genomes harbor numerous genomic alterations and many cancers accumulate thousands of nucleotide sequence variations. A prominent fraction of these mutations arises as a consequence of the off-target activity of DNA/RNA editing cytosine deamina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cd524e433640ae19faa5d4ead93ff1
Autor:
Elena I. Stepchenkova, Igor B. Rogozin, Youri I. Pavlov, Jian Cui, Roman Fedorov, Elena Tarakhovskaya, Artem G. Lada, Eugenia Poliakov, Stephanie R. Barbari, Polina V. Shcherbakova, Dmitrii E. Polev, Anna S. Zhuk
Publikováno v:
Genetics
Current eukaryotic replication models postulate that leading and lagging DNA strands are replicated predominantly by dedicated DNA polymerases. The catalytic subunit of the leading strand DNA polymerase ε, Pol2, consists of two halves made of two di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1efb4356a75afe0bf45426f3a90cb67
https://pubmed.ncbi.nlm.nih.gov/33844024
https://pubmed.ncbi.nlm.nih.gov/33844024
Autor:
David Neil Cooper, Subhajyoti De, Artem G. Lada, Igor B. Rogozin, Anna R. Panchenko, German Nudelman, Youri I. Pavlov, Vyacheslav Yurchenko, Alexander Goncearenco
Publikováno v:
Cell Cycle. 17:348-355
DNA polymerase (pol) η is a specialized error-prone polymerase with at least two quite different and contrasting cellular roles: to mitigate the genetic consequences of solar UV irradiation, and promote somatic hypermutation in the variable regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942a7b9f12c4319eb6ff0290a87ac656
https://doi.org/10.1080/15384101.2017.1404208
https://doi.org/10.1080/15384101.2017.1404208
Autor:
Igor B. Rogozin, Abiel Roche-Lima, David Neil Cooper, Galina V. Glazko, Ivan A. Sidorenko, Vladimir N. Babenko, Artem G. Lada, Frida Belinky, Youri I. Pavlov
Publikováno v:
Cancers, vol 11, iss 2
Cancers
Volume 11
Issue 2
Cancers, Vol 11, Iss 2, p 211 (2019)
Cancers
Volume 11
Issue 2
Cancers, Vol 11, Iss 2, p 211 (2019)
Cancer genomes accumulate nucleotide sequence variations that number in the tens of thousands per genome. A prominent fraction of these mutations is thought to arise as a consequence of the off-target activity of DNA/RNA editing cytosine deaminases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f7f071e2f3e11aa6625f98b65934c4
https://orca.cardiff.ac.uk/id/eprint/120099/1/cancers-11-00211-v3.pdf
https://orca.cardiff.ac.uk/id/eprint/120099/1/cancers-11-00211-v3.pdf