Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Artelinic acid"'
Autor:
Moussa Sehailia, Smain Chemat
Publikováno v:
Journal of Biomolecular Structure & Dynamics
article-version (VoR) Version of Record
Journal of Biomolecular Structure and Dynamics
article-version (VoR) Version of Record
Journal of Biomolecular Structure and Dynamics
Medicinal herbs have proved along history to be a source of multiple cures. In this paper, we demonstrate how hydroxychloroquine can act as a good inhibitor of SARS-CoV-2 Spike protein receptor-binding-domain using molecular docking studies. We also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0203f9af273d05d201a2477189b8730
Autor:
Ruili Wang, Wenju Guo, Guolian Ren, Shuqiu Zhang, Ning Li, Jiaqi Tang, Qingshan Yang, Shuai Duan, Rongrong Wang, Xiaoyang Xiao
Publikováno v:
Parasitology
It is urgent to develop new antimalarial drugs with good therapeutic effects to address the emergence of drug resistance. Here, the artelinic acid-choline derivative (AD) was synthesized by dehydration reaction and esterification reaction, aimed to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbe530dd4f5cf5d46d458c0591e45f3
https://europepmc.org/articles/PMC10317620/
https://europepmc.org/articles/PMC10317620/
Akademický článek
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Publikováno v:
Scientific Reports
The potent anti-malarial drug artemisinins are additionally anti-tumorigenic and inhibitory to yeast growth. The action mechanism of artemisinins, however, is not well understood. Heme and mitochondrial membrane are both suggested to be involved in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce8ac5c4c139f95bcee28b2e593a411
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:428-431
The appearance of Plasmodium falciparum parasites with decreased in vivo sensitivity but no measurable in vitro resistance to artemisinin has raised the urgent need to characterize the artemisinin resistance phenotype. Changes in the temporary growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0722fa0283856186ec5253acb1075910
https://doi.org/10.1128/aac.05456-11
https://doi.org/10.1128/aac.05456-11
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:302-314
Emergence of artemisinin resistance in Cambodia highlights the importance of characterizing resistance to this class of drugs. Previously, intermediate levels of resistance in Plasmodium falciparum were generated in vitro for artelinic acid (AL) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168e83d2e7b5534d5375ff4d4d857769
https://doi.org/10.1128/aac.05540-11
https://doi.org/10.1128/aac.05540-11
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 92:52-68
The artemisinin antimalarials cause embryo death and malformations in animals by killing embryonic erythroblasts. Groups of pregnant rats (N = 4) were administered 35 and 48 µmol/kg artesunate and 17.2, 28.7, 48, 96, and 191 µmol/kg artelinic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5a49a6f10a21f587f30953645f6887
https://doi.org/10.1002/bdrb.20282
https://doi.org/10.1002/bdrb.20282
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:2455-2464
Artemisinin and its derivatives are the most rapidly acting and efficacious antimalarial drugs currently available. Although resistance to these drugs has not been documented, there is growing concern about the potential for resistance to develop. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e1998e13f1e1fffb2da4e06c8b09b1
https://doi.org/10.1128/aac.00947-09
https://doi.org/10.1128/aac.00947-09
Autor:
Mitchell A. Avery, K. M. Muraleedharan
Publikováno v:
Drug Discovery Today. 14:793-803
Progress made in the past decade pertaining to the development of anti-parasitic agents based on artemisinin is presented. Apart from discussions on important derivatives obtained through functionalization at the C-3, C-9, C-10 and O-11 positions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3f7138dc216e19dcefc0cb073f56e9
https://doi.org/10.1016/j.drudis.2009.05.008
https://doi.org/10.1016/j.drudis.2009.05.008
Publikováno v:
Current Drug Metabolism. 10:289-306
There are several clinically useful endoperoxides, mainly artemisinin derivatives available in market for the treatment of malaria. These are highly potent drugs, with fastest parasite reduction ratio, broadest parasite stage specificity and effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee455036e5bc38b1ed4591b1845b881
https://doi.org/10.2174/138920009787846323
https://doi.org/10.2174/138920009787846323