Intracellular Angiotensin‐II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion

Autor: Artavazd Tadevosyan, Jiening Xiao, Sirirat Surinkaew, Patrice Naud, Clémence Merlen, Masahide Harada, Xiaoyan Qi, David Chatenet, Alain Fournier, Bruce G. Allen, Stanley Nattel

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 4 (2017)

BackgroundCardiac fibroblasts play important functional and pathophysiological roles. Intracellular (“intracrine”) angiotensin‐II (Ang‐II) signaling regulates intercellular communication, excitability, and gene expression in cardiomyocytes; h

Externí odkaz: https://doaj.org/article/d663a4d5df9747c482bc5f5e30713103

Caged ligands to study the role of intracellular GPCRs

Autor: Stanley Nattel, Bruce G. Allen, Artavazd Tadevosyan, Alain Fournier, Louis Villeneuve, David Chatenet

Publikováno v: Methods
Methods, Elsevier, 2016, 92, pp.72-7. ⟨10.1016/j.ymeth.2015.07.005⟩

International audience; In addition to cell surface membranes, numerous G protein-coupled receptors (GPCRs) are located on intracellular membranes including the nuclear envelope. Although the role of numerous GPCRs at the cell surface has been well c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a360df135c072be3621dfe798a3a0a3
https://doi.org/10.1016/j.ymeth.2015.07.005

Fibroblast Inward-Rectifier Potassium Current Upregulation in Profibrillatory Atrial Remodeling

Autor: Xiaobin Luo, Hai Huang, Stanley Nattel, Dobromir Dobrev, Yu Chen, Xiao Yan Qi, Yiguo Sun, Artavazd Tadevosyan, Masahide Harada, Kristin Dawson, Patrice Naud, Balázs Ördög, Chia Tung Wu

Publikováno v: Circulation Research. 116:836-845

Rationale: Fibroblasts are involved in cardiac arrhythmogenesis and contribute to the atrial fibrillation substrate in congestive heart failure (CHF) by generating tissue fibrosis. Fibroblasts display robust ion currents, but their functional importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1b49361c8ed11bcc16bb0eb21dcf81
https://doi.org/10.1161/circresaha.116.305326

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease

Autor: Artavazd Tadevosyan, I. Slassi, B. El Moutawakil, N. El Kadmiri, Sellama Nadifi, Abdelaziz Soukri, Ahmed Hachem

Publikováno v: Pathologie Biologie. 62:333-336

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a ubiquitous enzyme that catalyzes the sixth step of glycolysis and thus, serves to break down glucose for energy production. Beyond the traditional aerobic metabolism of glucose, recent studies hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f8cd297a949bca85d957a213783564
https://doi.org/10.1016/j.patbio.2014.08.002

Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors

Autor: Terence E. Hébert, Alain Fournier, Michel Therien, Stanley Nattel, Bruce G. Allen, Carter Smith, George Vaniotis, Louis Villeneuve, Clémence Merlen, David Chatenet, Artavazd Tadevosyan, Irina Glazkova, Phan Trieu

Publikováno v: Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2013, 62, pp.58-68. ⟨10.1016/j.yjmcc.2013.05.003⟩

International audience; At the cell surface, βARs and endothelin receptors can regulate nitric oxide (NO) production. β-adrenergic receptors (βARs) and type B endothelin receptors (ETB) are present in cardiac nuclear membranes and regulate transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69536f434be0c63d561a56625b70d573
https://doi.org/10.1016/j.yjmcc.2013.05.003