Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Arta M, Monjazeb"'
Autor:
Craig P. Collins, Lam T. Khuat, Gail D. Sckisel, Logan V. Vick, Christine M. Minnar, Cordelia Dunai, Catherine T. Le, Brendan D. Curti, Marka Crittenden, Alexander Merleev, Michael Sheng, Nelson J. Chao, Emanual Maverakis, Spencer R. Rosario, Arta M. Monjazeb, Bruce R. Blazar, Dan L. Longo, Robert J. Canter, William J. Murphy
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked involution, reducing naïve T-cell output and resulting in a predominance of long-lived memory T c
Externí odkaz:
https://doaj.org/article/1e288536df9248b1a327800dd3a6007e
Autor:
Arta M. Monjazeb, Megan E. Daly, Guillaume Luxardi, Emanual Maverakis, Alexander A. Merleev, Alina I. Marusina, Alexander Borowsky, Amin Mirhadi, Stephen L. Shiao, Laurel Beckett, Shuai Chen, David Eastham, Tianhong Li, Logan V. Vick, Heather M. McGee, Frances Lara, Leslie Garcia, Leigh Anne Morris, Robert J. Canter, Jonathan W. Riess, Kurt A. Schalper, William J. Murphy, Karen Kelly
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Stereotactic ablative radiotherapy (SABR) is a standard-of-care for medically-inoperable-early-stage non-small cell lung cancer (NSCLC). One third of patients progress and chemotherapy is rarely used in this population. We questioned if addi
Externí odkaz:
https://doaj.org/article/28952647439e48d680160b1ba89a37c4
Autor:
Catherine T. Le, Logan V. Vick, Craig Collins, Cordelia Dunai, Michael K. Sheng, Lam T. Khuat, Isabel Barao, Sean J. Judge, Ethan G. Aguilar, Brendan Curti, Maneesh Dave, Dan L. Longo, Bruce R. Blazar, Robert J. Canter, Arta M. Monjazeb, William J. Murphy
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
Bystander activation of memory T cells occurs via cytokine signaling alone in the absence of T cell receptor (TCR) signaling and provides a means of amplifying T cell effector responses in an antigen-nonspecific manner. While the role of Programmed C
Externí odkaz:
https://doaj.org/article/61038b8528944e2fac44a9057e6d02fd
Autor:
Sylvia M. Cruz, Cyrus J. Sholevar, Sean J. Judge, Morgan A. Darrow, Khurshid R. Iranpur, Lauren E. Farley, Marshall Lammers, Aryana M. Razmara, Cordelia Dunai, Alicia A. Gingrich, Julia Persky, Hidetoshi Mori, Steven W. Thorpe, Arta M. Monjazeb, William J. Murphy, Robert J. Canter
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSoft tissue sarcomas (STS) are rare, heterogenous malignancies with an unmet need for novel immunotherapies. Tumor infiltrating lymphocytes (TILs) have been linked with favorable outcomes in STS patients, though the contribution of natura
Externí odkaz:
https://doaj.org/article/38ddffd1c7f44bb0894db785ef35ebf4
Autor:
Nian Jiang, Bowen Xie, Wenwu Xiao, Ming Fan, Shanxiu Xu, Yixin Duan, Yamah Hamsafar, Angela C. Evans, Jie Huang, Weibing Zhou, Xuelei Lin, Ningrong Ye, Siyi Wanggou, Wen Chen, Di Jing, Ruben C. Fragoso, Brittany N. Dugger, Paul F. Wilson, Matthew A. Coleman, Shuli Xia, Xuejun Li, Lun-Quan Sun, Arta M. Monjazeb, Aijun Wang, William J. Murphy, Hsing-Jien Kung, Kit S. Lam, Hong-Wu Chen, Jian Jian Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Acquired radioresistance is a challenge for the cure of glioblastoma. Here, the authors show that radioresistant glioblastoma boosts mitochondrial fatty acid oxidation that fuels cell proliferation and induces immunosuppression via CD47 mediated anti
Externí odkaz:
https://doaj.org/article/9ea4ad505be945a8af46118fb26c43d3
Autor:
Logan V. Vick, Craig P. Collins, Lam T. Khuat, Ziming Wang, Cordelia Dunai, Ethan G. Aguilar, Kevin Stoffel, Sai Yendamuri, Randall Smith, Sarbajit Mukherjee, Joseph Barbi, Robert J. Canter, Arta M. Monjazeb, William J. Murphy
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionThe incidence of obesity, a condition characterized by systemic chronic inflammation, has reached pandemic proportions and is a poor prognostic factor in many pathologic states. However, its role on immune parameters has been diverse and
Externí odkaz:
https://doaj.org/article/c987ad8e2be041e09bc0520fda51dba8
Autor:
Sean J. Judge, Joshua D. Bloomstein, Cyrus J. Sholevar, Morgan A. Darrow, Kevin M. Stoffel, Logan V. Vick, Cordelia Dunai, Sylvia M. Cruz, Aryana M. Razmara, Arta M. Monjazeb, Robert B. Rebhun, William J. Murphy, Robert J. Canter
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
PurposeClinical successes using current T-cell based immunotherapies have been limited in soft tissue sarcomas (STS), while pre-clinical studies have shown evidence of natural killer (NK) cell activity. Since tumor immune infiltration, especially tum
Externí odkaz:
https://doaj.org/article/9ec99ada9f4e4f46aeaeab1be4c9ae38
Autor:
Demet Candas-Green, Bowen Xie, Jie Huang, Ming Fan, Aijun Wang, Cheikh Menaa, Yanhong Zhang, Lu Zhang, Di Jing, Soheila Azghadi, Weibing Zhou, Lin Liu, Nian Jiang, Tao Li, Tianyi Gao, Colleen Sweeney, Rulong Shen, Tzu-yin Lin, Chong-xian Pan, Omer M. Ozpiskin, Gayle Woloschak, David J. Grdina, Andrew T. Vaughan, Ji Ming Wang, Shuli Xia, Arta M. Monjazeb, William J. Murphy, Lun-Quan Sun, Hong-Wu Chen, Kit S. Lam, Ralph R. Weichselbaum, Jian Jian Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The emergence of tumour adaptive radioresistance can limit the success of radiation therapy and immunotherapy in breast cancer. In this study, the authors demonstrate that CD47 and HER2 are coordinating in tumor response to radiation and that co-bloc
Externí odkaz:
https://doaj.org/article/278b23d810204e89b5b3f18e5d760fef
Autor:
Ellen E. Sparger, Hong Chang, Ning Chin, Robert B. Rebhun, Sita S. Withers, Hung Kieu, Robert J. Canter, Arta M. Monjazeb, Michael S. Kent
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
Investigation of canine T cell immunophenotypes in canine melanomas as prognostic biomarkers for disease progression or predictive biomarkers for targeted immunotherapeutics remains in preliminary stages. We aimed to examine T cell phenotypes and fun
Externí odkaz:
https://doaj.org/article/0cfee634520c4c68a85e229019c24a1f
Autor:
Lam T. Khuat, Logan V. Vick, Eunju Choi, Cordelia Dunai, Alexander A. Merleev, Emanual Maverakis, Bruce R. Blazar, Arta M. Monjazeb, William J. Murphy
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by the occurrence of acute and chronic graft-versus-host disease (GVHD). We have recently demonstrated that obesity results in exacerbated acute gastrointestina
Externí odkaz:
https://doaj.org/article/581f8689a69c4817a6e50c308b7a13b6