Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Art. E. Cho"'
Autor:
Pankaj Attri, Jitender Gaur, Sooho Choi, Minsup Kim, Rohit Bhatia, Naresh Kumar, Ji Hoon Park, Art. E. Cho, Eun Ha Choi, Weontae Lee
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Most cancer cells have telomerase activity because they can express the human telomerase reverse transcriptase (hTERT) gene. Therefore, the inhibition of the hTERT expression can play an important role in controlling cancer cell proliferatio
Externí odkaz:
https://doaj.org/article/1efb67bb46e745999fd5b85bddaf75eb
Autor:
Eun Hee Jo, Ji Eun Moon, Moon Han Chang, Ye Jin Lim, Jung Hyun Park, Suk Hee Lee, Young Rae Cho, Art E Cho, Seung Pil Pack, Hyeon-Wee Kim, Liana Crowley, Brandy Le, Aykin-Burns Nukhet, Yinfeng Chen, Yihang Zhong, Jiangchao Zhao, Ying Li, Hanvit Cha, Jeong Hoon Pan, Jae Kyeom Kim, Jin Hyup Lee
Publikováno v:
Journal of Advanced Research, Vol 46, Iss , Pp 17-29 (2023)
Introduction: Epidemiological studies have reported an association between exposures to ambient air pollution and respiratory diseases, including chronic obstructive pulmonary disease (COPD). Pneumonitis is a critical driving factor of COPD and expos
Externí odkaz:
https://doaj.org/article/de974d4fabfe4b4c9169ee3b54c3304f
Autor:
Seo-Jung Han, Jae Eun Jung, Do Hee Oh, Minsup Kim, Jae-Min Kim, Kyung-Sook Chung, Hee-Soo Han, Jeong-Hun Lee, Kyung-Tae Lee, Hee Jin Jeong, In Ho Park, Eunkyeong Jeon, Jeon-Soo Shin, Dongkeun Hwang, Art E. Cho, Duck-Hyung Lee, Taebo Sim
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1257-1277 (2022)
Identification of highly selective type II kinase inhibitors is described. Two different chiral peptidomimetic scaffolds were introduced on the tail region of non-selective type II kinase inhibitor GNF-7 to enhance the selectivity. Kinome-wide select
Externí odkaz:
https://doaj.org/article/c5691771b8354940857012412b9bca79
Publikováno v:
Journal of Chemical Information and Modeling. 63:2728-2734
Autor:
Yong Zhang, Hisae Tateishi-Karimata, Tamaki Endoh, Qiongli Jin, Kexin Li, Xiaoru Fan, Yingjun Ma, Limin Gao, Haiyan Lu, Zhiye Wang, Art E. Cho, Xuefeng Yao, Chunming Liu, Naoki Sugimoto, Shiwei Guo, Xiangdong Fu, Qirong Shen, Guohua Xu, Luis Rafael Herrera-Estrella, Xiaorong Fan
Publikováno v:
Science Advances. 8
Climate change negatively affects crop yield, which hinders efforts to reach agricultural sustainability and food security. Here, we show that a previously unidentified allele of the nitrate transporter gene OsNRT2.3 is required to maintain high yiel
Publikováno v:
Toxicology and Applied Pharmacology. 470:116546
Autor:
Ji-ung Yang, Soyeon Kim, Art E. Cho, Byeong Woo Yang, Bokyung Sung, Yeoun-Hee Kim, Yongmin Chang, Chang-Hoon Shin, Ah Rum Baek, Minsup Kim, Hee-Kyung Kim, Hoesu Jung, Taekwan Lee, Jung-jin Lee
Publikováno v:
Journal of Industrial and Engineering Chemistry. 95:83-91
Glutamate is an important excitatory neurotransmitter, and vesicular glutamate transporters (VGLUTs) are critical in regulating the extent of glutamate release. Because initial increase and late stage decrease in VGLUT expression were implicated in p
Publikováno v:
Journal of Chemical Information and Modeling. 61:36-45
Following identification of a target protein, hit identification, which finds small organic molecules that bind to the target, is an important first step of a structure-based drug design project. In this study, we demonstrate a target-specific drug d
Autor:
Ah Rum Baek, Hee-Kyung Kim, Soyeon Kim, Ji-ung Yang, Min-Kyoung Kang, Jae Jun Lee, Bokyung Sung, Hyeji Lee, Minsup Kim, Art E. Cho, Ji-Ae Park, Yongmin Chang
Publikováno v:
Journal of medicinal chemistry. 65(8)
The purpose of this study is to assess the physicochemical properties and MRI diagnostic efficacy of two newly synthesized 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-type Gd chelates, Gd-SucL and Gd-GluL, with an asymmetric α-su
Autor:
Kyeong Lee, Ja Il Goo, Jae Hong Kim, Yongseok Choi, Art E. Cho, Dipesh S. Harmalkar, Jun Dong Wei, Minsup Kim
Publikováno v:
ACS Medicinal Chemistry Letters. 11:1529-1534
G protein-coupled receptors (GPCRs) have always been important drug targets in the pharmaceutical industry. One major question for the current GPCR drug discovery is how drugs have distinct efficacies at the same GPCR target. Related to this question