Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Art Hanel"'
Autor:
Xiang Wu, Jeff Zhang, Amanda Harrison, Jing Wang, Eric Brooks, Art Hanel, Wentao Zhang, Shaun Nguyen
Publikováno v:
SLAS Discovery. 19:1193-1200
Recurrent genetic mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) have been identified in multiple tumor types. The most frequent mutation, IDH1 R132H, is a gain-of-function mutation resulting in an enzyme-catalyzing conversion of α-ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a677e364c036805fcf477b52acf8bfb7
https://doi.org/10.1177/1087057114541148
https://doi.org/10.1177/1087057114541148
Autor:
Danny Tam, Amanda Harrison, Jason August Nachtigall, Fawn Qian, Ron Aoyama, Jon Rosen, Peter Lamb, Tao Wang, Artur Plonowski, Belinda Cancilla, Naing Aay, Elena S. Koltun, Patrick Kearney, Adam A. Galan, Arlyn Arcalas, Kwang-Ai Won, Wentao Zhang, Raju Mohan, Hongwang Du, Vicky Chan, Art Hanel, Patricia Finn, Michael Yakes, Jeff Zhang, Richards Steven J, Frauke Bentzien, John M. Nuss, Kathy Ogilvie, Christopher J. Larson
Publikováno v:
Journal of Medicinal Chemistry. 55:4322-4335
Targeting glycosphingolipid synthesis has emerged as a novel approach for treating metabolic diseases. 32 (EXEL-0346) represents a new class of glucosylceramide synthase (GCS) inhibitors. This report details the elaboration of hit 8 with the goal of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd8c748fee52922d91c2b98ea12917f
https://doi.org/10.1021/jm300122u
https://doi.org/10.1021/jm300122u
Autor:
Patricia Finn, Jeff Zhang, Patrick Kearney, Raju Mohan, Tao Wang, Peter Lamb, Vicky Chan, Danny Tam, Christopher J. Larson, Kwang-Ai Won, Adam A. Galan, Amanda Harrison, Jason August Nachtigall, Art Hanel, Jon Rosen, Richards Steven J, John M. Nuss, Naing Aay, Fawn Qian, Kevin Noson, Kathleen M. Ogilvie, Hongwang Du, Elena S. Koltun
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6773-6777
A novel series of potent inhibitors of glucosylceramide synthase are described. The optimization of biochemical and cellular potency as well as ADME properties led to compound 23c. Broad tissue distribution was obtained following oral administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68aa3f4462e296a5ca699bcb45dea236
https://doi.org/10.1016/j.bmcl.2011.09.037
https://doi.org/10.1016/j.bmcl.2011.09.037
Autor:
James W. Leahy, Shouming Wang, Michael P. Prisbylla, Morrison B. Mac, Nigel Vicker, Patrick Kearney, Golec Julian M C, Robert R. Webb, David A. Matthews, Reyna J. Simon, Art Hanel, Richard Faint, Jason Terry Sanderson, Erin Engelhardt, S. David Brown, Peter Charlton, Lynne Canne, Jocelyn Chan, Sergey Epshteyn, Adrian Folkes, Zerom Tesfai
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(7)
We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671f607b97c9700b0f71a5083a040633
https://pubmed.ncbi.nlm.nih.gov/11909718
https://pubmed.ncbi.nlm.nih.gov/11909718