Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Art F Y, Poon"'
Autor:
Ocean Thakali, Élisabeth Mercier, Walaa Eid, Martin Wellman, Julia Brasset-Gorny, Alyssa K. Overton, Jennifer J. Knapp, Douglas Manuel, Trevor C. Charles, Lawrence Goodridge, Eric J. Arts, Art F. Y. Poon, R. Stephen Brown, Tyson E. Graber, Robert Delatolla, Christopher T. DeGroot, Ontario Wastewater Surveillance Consortium
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Wastewater surveillance of coronavirus disease 2019 (COVID-19) commonly applies reverse transcription-quantitative polymerase chain reaction (RT-qPCR) to quantify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA concentration
Externí odkaz:
https://doaj.org/article/bc74bea4a03940bd85b38f29b9ec9203
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010745 (2022)
Clusters of genetically similar infections suggest rapid transmission and may indicate priorities for public health action or reveal underlying epidemiological processes. However, clusters often require user-defined thresholds and are sensitive to no
Externí odkaz:
https://doaj.org/article/67112e635a2a48d4927fd8683a38d966
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010649 (2022)
Externí odkaz:
https://doaj.org/article/52b815c5ad26441aa90adf6a7bbbb0d1
Autor:
Laura Muñoz-Baena, Art F Y Poon
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010331 (2022)
Gene overlap occurs when two or more genes are encoded by the same nucleotides. This phenomenon is found in all taxonomic domains, but is particularly common in viruses, where it may increase the information content of compact genomes or influence th
Externí odkaz:
https://doaj.org/article/66d9c00919564226bc190594146b85c4
Publikováno v:
Ecology and Evolution, Vol 9, Iss 12, Pp 6756-6771 (2019)
Abstract Cophylogeny is the congruence of phylogenetic relationships between two different groups of organisms due to their long‐term interaction. We investigated the use of tree shape distance measures to quantify the degree of cophylogeny. We imp
Externí odkaz:
https://doaj.org/article/e7245970f56d4a9d99541479d3cc083d
Autor:
Art F. Y. Poon, Emmanuel Ndashimye, Mariano Avino, Richard Gibson, Cissy Kityo, Fred Kyeyune, Immaculate Nankya, Miguel E. Quiñones-Mateu, Eric J. ARTS, The Ugandan Drug Resistance Study Team
Publikováno v:
AIDS Research and Therapy, Vol 16, Iss 1, Pp 1-10 (2019)
Abstract Background Our understanding of HIV-1 and antiretroviral treatment (ART) is strongly biased towards subtype B, the predominant subtype in North America and western Europe. Efforts to characterize the response to first-line treatments in othe
Externí odkaz:
https://doaj.org/article/13c4971b67a049ee97aed1d41b3aa192
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0259877 (2021)
The shape of phylogenetic trees can be used to gain evolutionary insights. A tree's shape specifies the connectivity of a tree, while its branch lengths reflect either the time or genetic distance between branching events; well-known measures of tree
Externí odkaz:
https://doaj.org/article/e17a4155de8c456d83047b21a9fbb94e
Autor:
Art F. Y. Poon, Jessica L. Prodger, Briana A. Lynch, Jun Lai, Steven J. Reynolds, Jingo Kasule, Adam A. Capoferri, Susanna L. Lamers, Christopher W. Rodriguez, Daniel Bruno, Stephen F. Porcella, Craig Martens, Thomas C. Quinn, Andrew D. Redd
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-13 (2018)
Abstract Background The ability of HIV-1 to integrate into the genomes of quiescent host immune cells, establishing a long-lived latent viral reservoir (LVR), is the primary obstacle to curing these infections. Quantitative viral outgrowth assays (QV
Externí odkaz:
https://doaj.org/article/4d01e2c8aea6476a8534c3ba69e20e43
Autor:
Hope R. Lapointe, Weiyan Dong, Winnie W. Y. Dong, Don Kirkby, Conan Woods, Art F. Y. Poon, Anita Y. M. Howe, P. Richard Harrigan, Chanson J. Brumme
Publikováno v:
Viruses, Vol 13, Iss 9, p 1721 (2021)
Despite the effectiveness of direct-acting antiviral agents in treating hepatitis C virus (HCV), cases of treatment failure have been associated with the emergence of resistance-associated substitutions. To better guide clinical decision-making, we d
Externí odkaz:
https://doaj.org/article/c5d94423d66d4929beeda20a089fc132
Autor:
Richard M. Gibson, Gabrielle Nickel, Michael Crawford, Fred Kyeyune, Colin Venner, Immaculate Nankya, Eva Nabulime, Emmanuel Ndashimye, Art F. Y. Poon, Robert A. Salata, Cissy Kityo, Peter Mugyenyi, Miguel E. Quiñones-Mateu, Eric J. Arts
Publikováno v:
Infectious Diseases of Poverty, Vol 6, Iss 1, Pp 1-13 (2017)
Abstract Background Thymidine analogs, namely AZT (Zidovudine or Retrovir™) and d4T (Stavudine or Zerit™) are antiretroviral drugs still employed in over 75% of first line combination antiretroviral therapy (cART) in Kampala, Uganda despite avers
Externí odkaz:
https://doaj.org/article/cc1b3016e85046149eaa13ef73e04de9