Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Arsun Bektas"'
Autor:
Roshni Roy, Pei-Lun Kuo, Julián Candia, Dimitra Sarantopoulou, Ceereena Ubaida-Mohien, Dena Hernandez, Mary Kaileh, Sampath Arepalli, Amit Singh, Arsun Bektas, Jaekwan Kim, Ann Z Moore, Toshiko Tanaka, Julia McKelvey, Linda Zukley, Cuong Nguyen, Tonya Wallace, Christopher Dunn, William Wood, Yulan Piao, Christopher Coletta, Supriyo De, Jyoti Sen, Nan-ping Weng, Ranjan Sen, Luigi Ferrucci
Publikováno v:
eLife, Vol 12 (2023)
Age-associated DNA methylation in blood cells convey information on health status. However, the mechanisms that drive these changes in circulating cells and their relationships to gene regulation are unknown. We identified age-associated DNA methylat
Externí odkaz:
https://doaj.org/article/d686b4020d774313aa1c545d7788c07b
Autor:
Kelsey Gallant, Arsun Bektas, Mary Kaileh, Ana Lustig, Luigi Ferrucci, Gianluca Pegoraro, Tom Misteli
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract DNA damage is a prominent biomarker for numerous diseases, including cancer, as well as for the aging process. Detection of DNA damage routinely relies on traditional microscopy or cytometric methods. However, these techniques are typically
Externí odkaz:
https://doaj.org/article/83191778cc0142e08698fef978a85e5e
Publikováno v:
Immunity & Ageing, Vol 17, Iss 1, Pp 1-10 (2020)
Abstract A central clinical question as the world deals with the COVID-19 pandemic is what the long-term sequelae for the millions of individuals will be who recover from the hyperinflammatory state characterizing COVID-19 and in particular for the h
Externí odkaz:
https://doaj.org/article/b08679084cf1421aa5c591dfd937dc47
Autor:
Roshni Roy, Pei-Lun Kuo, Julián Candia, Dimitra Sarantopoulou, Ceereena Ubaida-Mohien, Dena Hernandez, Mary Kaileh, Sampath Arepalli, Amit Singh, Arsun Bektas, Jaekwan Kim, Ann Zenobia Moore, Toshiko Tanaka, Julia McKelvey, Linda Zukley, Cuong Nguyen, Tonya Wallace, Christopher Dunn, William Wood, Yulan Piao, Christopher Coletta, Supriyo De, Jyoti Misra Sen, Nan-ping Weng, Ranjan Sen, Luigi Ferrucci
Age-associated DNA methylation in blood cells convey information on health status. However, the mechanisms that drive these changes in circulating cells and their relationships to gene regulation are unknown. We identified age-associated DNA methylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48375812d9541b74e205fcd205a7d98f
https://doi.org/10.1101/2023.01.23.525162
https://doi.org/10.1101/2023.01.23.525162
Autor:
Amit Singh, Christopher A. Dunn, Fernando Macian, Marta Gonzalez-Freire, Arsun Bektas, Luigi Ferrucci, Ana Maria Cuervo, Shepherd H. Schurman, Ranjan Sen
Publikováno v:
Aging. 11:9234-9263
To gain understanding on the mechanisms that drive immunosenescence in humans, we examined CD4+ T cells obtained from younger (20-39 years-old) and older (70+ years-old) healthy participants of the Baltimore Longitudinal Study on Aging (BLSA). We fou
Autor:
Gianluca Pegoraro, Kelsey Gallant, Tom Misteli, Arsun Bektas, Ana Lustig, Luigi Ferrucci, Mary Kaileh
Publikováno v:
Scientific reports. 12(1)
DNA damage is a prominent biomarker for numerous diseases, including cancer, as well as for the aging process. Detection of DNA damage routinely relies on traditional microscopy or cytometric methods. However, these techniques are typically of limite
Autor:
Sören Boller, Tonya Wallace, Christopher E. Coletta, Dimitra Sarantopoulou, Julia McKelvey, Yulan Piao, Luigi Ferrucci, Cuong Q. Nguyen, Sampath Arepalli, Benjamin D. Shapiro, Christopher A. Dunn, Mary Kaileh, Ranjan Sen, Dena G. Hernandez, Linda Zukley, Nan-ping Weng, Arsun Bektas, Alexis Battle, Roshni Roy, Ann Zenobia Moore, Senthilkumar Ramamoorthy, Supriyo De, Toshiko Tanaka, Kevin G. Becker, Rudolf Grosschedl, Amit Singh, William H. Wood, Jaekwan Kim, Jyoti Misra Sen, Robert P. Wersto
Publikováno v:
Immunity
Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that uniquely define immune cell types and the mechanisms by which they are established remain unclear. Here, we identified lineage-specific DNA methylation signat
Autor:
Amit K Singh, Roshni Roy, Mary Kaileh, Dimitra Sarantopoulou, Dena Hernandez, Sampath Arepalli, Arsun Bektas, Jaekwan Kim, Julia McKelevy, Linda Zukely, Christopher Dunn, Cuong Nguyen, Tonya Wallace, William Wood, Yulan Piao, Supriyo De, Jyoti Misra Sen, Nan-ping Weng, Luigi Ferrucci, Ranjan Sen
Publikováno v:
The Journal of Immunology. 208:168.11-168.11
Long-term immunity against infections and effective response to vaccination are dependent on remarkable and unique feature of lymphocytes referred as “memory generation”. Despite having multiple mice studies focused on naïve to memory transition
Autor:
Hong Xu, Shepherd H. Schurman, Artiom Gruzdev, Stavros Garantziotis, Frederick W. Miller, Darryl C. Zeldin, Arsun Bektas, John A. McGrath, Terrance P. O'Hanlon
Publikováno v:
J Autoimmun
Background Because immune responses are sensitive to environmental changes that drive selection of genetic variants, we hypothesized that polymorphisms of some xenobiotic response and immune response genes may be associated with specific types of imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384c8255f3ec8f746d8178ba3b841d70
https://europepmc.org/articles/PMC7237321/
https://europepmc.org/articles/PMC7237321/
Autor:
Amit K Singh, Mary Kaileh, Krystyna Mazan-Mamczarz, Ajay Palagani, Roshni Roy, Dimitra Sarantopoulou, Ceereena Ubaida-Mohien, Ann Zenobia Moore, Yong Qian, Jinhu Yin, Arsun Bektas, Jun Ding, Supriyo De, Linda Zukley, Julia McKelvey, Nan-Ping Weng, Luigi Ferrucci, Ranjan Sen
Publikováno v:
The Journal of Immunology. 206:64.18-64.18
Human aging is associated with low grade chronic inflammation termed, inflammaging, which is a significant risk factor for morbidity and mortality in elderly. The innate immune system is master regulator of this process via regulating expression of c