Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Arshad Desai"'
Autor:
Romain O. Georges, Hugo Sepulveda, J. Carlos Angel, Eric Johnson, Susan Palomino, Roberta B. Nowak, Arshad Desai, Isaac F. López-Moyado, Anjana Rao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Inducible disruption of TET dioxygenases in mouse embryonic stem cells results in chromosome mis-segregation and aneuploidies, due to Khdc3 downregulation suggesting a role for TET enzymes and DNA methylation patterns in maintaining genome stability.
Externí odkaz:
https://doaj.org/article/75e3675d24e549509b33c5c6dfd59230
Autor:
Renat N Khaliullin, Rebecca A Green, Linda Z Shi, J Sebastian Gomez-Cavazos, Michael W Berns, Arshad Desai, Karen Oegema
Publikováno v:
eLife, Vol 7 (2018)
To ensure timely cytokinesis, the equatorial actomyosin contractile ring constricts at a relatively constant rate despite its progressively decreasing size. Thus, the per-unit-length constriction rate increases as ring perimeter decreases. To underst
Externí odkaz:
https://doaj.org/article/0d52aaadbadb4c0ca0f25ecc3c1fa313
Autor:
Kian-Yong Lee, Rebecca A Green, Edgar Gutierrez, J Sebastian Gomez-Cavazos, Irina Kolotuev, Shaohe Wang, Arshad Desai, Alex Groisman, Karen Oegema
Publikováno v:
eLife, Vol 7 (2018)
Throughout metazoans, germ cells undergo incomplete cytokinesis to form syncytia connected by intercellular bridges. Gamete formation ultimately requires bridge closure, yet how bridges are reactivated to close is not known. The most conserved bridge
Externí odkaz:
https://doaj.org/article/8d54a258e8bc4974992ec3a275f36ca7
Autor:
Rahul V Nene, Christopher D Putnam, Bin-Zhong Li, Katarina G Nguyen, Anjana Srivatsan, Christopher S Campbell, Arshad Desai, Richard D Kolodner
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007170 (2018)
Defects in the genes encoding the Paf1 complex can cause increased genome instability. Loss of Paf1, Cdc73, and Ctr9, but not Rtf1 or Leo1, caused increased accumulation of gross chromosomal rearrangements (GCRs). Combining the cdc73Δ mutation with
Externí odkaz:
https://doaj.org/article/e10b794a7beb46f09ac5db8e7a0c1cc8
Autor:
Julien Espeut, Pablo Lara-Gonzalez, Mélanie Sassine, Andrew K. Shiau, Arshad Desai, Ariane Abrieu
Publikováno v:
Cell Reports, Vol 12, Iss 1, Pp 58-65 (2015)
The spindle checkpoint safeguards against chromosome loss during cell division by preventing anaphase onset until all chromosomes are attached to spindle microtubules. Checkpoint signal is generated at kinetochores, the primary attachment site on chr
Externí odkaz:
https://doaj.org/article/fc73bbd3d699428ca29316d41833a503
Publikováno v:
eLife, Vol 6 (2017)
A protein called SAS-7 is required for daughter centrioles to become mothers in C. elegans.
Externí odkaz:
https://doaj.org/article/eaa4b29488804be4868d654ac622fadd
Autor:
Shaohe Wang, Di Wu, Sophie Quintin, Rebecca A Green, Dhanya K Cheerambathur, Stacy D Ochoa, Arshad Desai, Karen Oegema
Publikováno v:
eLife, Vol 4 (2015)
Non-centrosomal microtubule arrays assemble in differentiated tissues to perform mechanical and transport-based functions. In this study, we identify Caenorhabditis elegans NOCA-1 as a protein with homology to vertebrate ninein. NOCA-1 contributes to
Externí odkaz:
https://doaj.org/article/baee017e91814669bd62bbdfac8e06a8
Autor:
Andrea Musacchio, Arshad Desai
Publikováno v:
Biology, Vol 6, Iss 1, p 5 (2017)
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to its daughters. Kinetochores also control feedback mechanisms res
Externí odkaz:
https://doaj.org/article/9020eaf23ab847bcb32d3ff2b97d8a9b
Autor:
Christopher S Campbell, Hans Hombauer, Anjana Srivatsan, Nikki Bowen, Kerstin Gries, Arshad Desai, Christopher D Putnam, Richard D Kolodner
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004327 (2014)
In Saccharomyces cerevisiae, the essential mismatch repair (MMR) endonuclease Mlh1-Pms1 forms foci promoted by Msh2-Msh6 or Msh2-Msh3 in response to mispaired bases. Here we analyzed the Mlh1-Mlh2 complex, whose role in MMR has been unclear. Mlh1-Mlh
Externí odkaz:
https://doaj.org/article/495a2c90b0c046fe8c47ec0ea2fa3979
Autor:
Catherine E Smith, Marc L Mendillo, Nikki Bowen, Hans Hombauer, Christopher S Campbell, Arshad Desai, Christopher D Putnam, Richard D Kolodner
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003869 (2013)
Lynch syndrome (hereditary nonpolypsis colorectal cancer or HNPCC) is a common cancer predisposition syndrome. Predisposition to cancer in this syndrome results from increased accumulation of mutations due to defective mismatch repair (MMR) caused by
Externí odkaz:
https://doaj.org/article/16a0b87dd41042529c76ae4f33b5ed60