Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Arseniy S. Zhigulin"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Amidine-containing compounds are primarily known as antiprotozoal agents (pentamidine, diminazene, furamidine) or as serine protease inhibitors (nafamostat, sepimostat, camostat, gabexate). DAPI is widely recognized as a fluorescent DNA stain. Recent
Externí odkaz:
https://doaj.org/article/72c78277071c4f0c87d7950f81705ade
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1234 (2024)
N-methyl-D-aspartate (NMDA) receptors are inhibited by many medicinal drugs. The recent successful repurposing of NMDA receptor antagonists ketamine and dextromethorphan for the treatment of major depressive disorder further enhanced the interest in
Externí odkaz:
https://doaj.org/article/cbc20e37ce1149388170420e65f49317
Autor:
Arseniy S. Zhigulin, Oleg I. Barygin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15685 (2023)
N-methyl-D-aspartate (NMDA) receptors are inhibited by many amidine and guanidine compounds. In this work, we studied the mechanisms of their inhibition by sepimostat—an amidine-containing serine protease inhibitor with neuroprotective properties.
Externí odkaz:
https://doaj.org/article/499af7e13dd54f1298501a79da27d787
Autor:
Tatyana Y. Postnikova, Alexandra V. Griflyuk, Arseniy S. Zhigulin, Elena B. Soboleva, Oleg I. Barygin, Dmitry V. Amakhin, Aleksey V. Zaitsev
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12621 (2023)
Febrile seizures (FSs) are a relatively common early-life condition that can cause CNS developmental disorders, but the specific mechanisms of action of FS are poorly understood. In this work, we used hyperthermia-induced FS in 10-day-old rats. We de
Externí odkaz:
https://doaj.org/article/600eb257f29746c2afafc762a3061c51
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12974 (2023)
Proton-gated channels of the ASIC family are widely distributed in central neurons, suggesting their role in common neurophysiological functions. They are involved in glutamatergic neurotransmission and synaptic plasticity; however, the exact functio
Externí odkaz:
https://doaj.org/article/70fc3c7c12d94f9f932a1019d0832056
Autor:
Dmitry S. Karlov, Nadezhda S. Temnyakova, Dmitry A. Vasilenko, Oleg I. Barygin, Mikhail Y. Dron, Arseniy S. Zhigulin, Elena B. Averina, Yuri K. Grishin, Vladimir V. Grigoriev, Alexey V. Gabrel'yan, Viktor A. Aniol, Natalia V. Gulyaeva, Sergey V. Osipenko, Yury I. Kostyukevich, Vladimir A. Palyulin, Petr A. Popov, Maxim V. Fedorov
Publikováno v:
RSC Med Chem
NMDA (N-methyl-d-aspartate) receptor antagonists are promising tools for the treatment of a wide variety of central nervous system impairments including major depressive disorder. We present here the activity optimization process of a biphenyl-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3989af29a2bde731d47b62baa8a167
https://doi.org/10.1039/d2md00001f
https://doi.org/10.1039/d2md00001f
Publikováno v:
European Journal of Pharmacology. 938:175394
Acid-sensing ion channels (ASICs) are blocked by many cationic compounds. Mechanisms of action, which may include pore block, modulation of activation and desensitization, need systematic analysis to allow predictable design of new potent and selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5ea79b661ff011cb0e44556fbd4526
https://doi.org/10.1016/j.ejphar.2022.175394
https://doi.org/10.1016/j.ejphar.2022.175394
Autor:
Arseniy S. Zhigulin, Oleg I. Barygin
Publikováno v:
European Journal of Pharmacology. 919:174795
N-methyl-D-aspartate (NMDA) receptors are affected by many pharmaceuticals. In this work, we studied the action of the serine protease inhibitors nafamostat, gabexate and camostat, and an antiprotozoal compound, furamidine, on native NMDA receptors i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7946af0fc92427b661d6b874bb593d
https://doi.org/10.1016/j.ejphar.2022.174795
https://doi.org/10.1016/j.ejphar.2022.174795
Publikováno v:
The European journal of neuroscienceREFERENCES. 51(7)
Pentamidine, diminazene and 4',6-diamidino-2-phenylindole (DAPI) are antiprotozoal diarylamidine compounds. In the present work, we have studied their action on native N-methyl-D-aspartate (NMDA) receptors in rat hippocampal pyramidal neurons. All th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb0f750887a6ab6277e8b5cda231013
https://pubmed.ncbi.nlm.nih.gov/31605636
https://pubmed.ncbi.nlm.nih.gov/31605636