Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Arsenic trioxide (ATO)"'
Autor:
Igor Hrgovic, Eva Zöller, Monika Doll, Tsige Hailemariam-Jahn, Thilo Jakob, Roland Kaufmann, Markus Meissner, Johannes Kleemann
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 1, Pp 67-80 (2023)
Tumor-induced lymphangiogenesis is strongly associated with the formation of tumor metastasis. Therefore, the regulation of lymphangiogenesis offers a promising target in cancer therapy. Arsenic trioxide (ATO) is highly effective in the treatment of
Externí odkaz:
https://doaj.org/article/c4fd3bb368434a48bf4d340b790f9caf
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2580 (2023)
Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent form, accounting for more than 90% of all pancreatic malignancies. In a previous study, we found that hypoxia and chemotherapy induced expression of Heme Oxygenase-1 (HO-1) in PDAC cells a
Externí odkaz:
https://doaj.org/article/4acd1da41ecf440d9cee75e86974db46
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
The transformation of acute promyelocytic leukemia (APL) from an often fatal to highly curable cancer with long-term survival exceeding 90% is one of the greatest and most inspiring successes in oncology. A deeper understanding of the pathogenesis of
Externí odkaz:
https://doaj.org/article/a0cf548b97e2455182b0d2d900860b72
Autor:
Mohaddeseh Kazemi, Hamideh Kouhpeikar, Zahra Delbari, Faeze Khodadadi, Sina Gerayli, Mehrdad Iranshahi, Arman Mosavat, Fatemeh Rassouli, Houshang RafatPanah
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 24, Iss 12, Pp 1643-1649 (2021)
Objective(s): Despite advances in the treatment of adult T-cell leukemia/lymphoma (ATLL), the survival rate of this malignancy remains significantly low. Auraptene (AUR) is a natural coumarin with broad-spectrum anticancer activities. To introduce a
Externí odkaz:
https://doaj.org/article/042e9027871e47b187ca65b7872e06ea
Autor:
Dominic LaBella, Samuel Regan, Heiko Konig, Daniel N. Egan, Neil A. Bailey, Raya Mawad, Morgan Gilbert, John M. Pagel, Jeffrey J. Pu
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Acute Promyelocytic Leukemia (APL) is characterized by the t(15;17) chromosomal translocation resulting in a PML-RARA fusion protein. The all-trans-retinoic acid (ATRA) and Arsenic Trioxide (ATO) only regimens have demonstrated success in treating lo
Externí odkaz:
https://doaj.org/article/e3a605d3354d45f5be18821ef3ff9bac
Autor:
Yinping Zhao, Guangchao Zang, Tieying Yin, Xiaoyi Ma, Lifeng Zhou, Lingjuan Wu, Richard Daniel, Yunbing Wang, Juhui Qiu, Guixue Wang
Publikováno v:
Bioactive Materials, Vol 6, Iss 2, Pp 375-385 (2021)
Objective: Arsenic trioxide (ATO or As2O3) has beneficial effects on suppressing neointimal hyperplasia and restenosis, but the mechanism is still unclear. The goal of this study is to further understand the mechanism of ATO's inhibitory effect on va
Externí odkaz:
https://doaj.org/article/c9ddd09db8af4e63ac82badc42266381
Akademický článek
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Autor:
Agata N. Burska, Bayansulu Ilyassova, Aruzhan Dildabek, Medina Khamijan, Dinara Begimbetova, Ferdinand Molnár, Dos D. Sarbassov
Publikováno v:
Cells, Vol 11, Iss 21, p 3454 (2022)
The turn-on mutations of the KRAS gene, coding a small GTPase coupling growth factor signaling, are contributing to nearly 25% of all human cancers, leading to highly malignant tumors with poor outcomes. Targeting of oncogenic KRAS remains a most cha
Externí odkaz:
https://doaj.org/article/63c40894e1334db2ad76639131414761
Autor:
Dinh Hoa Hoang, Ralf Buettner, Melissa Valerio, Lucy Ghoda, Bin Zhang, Ya-Huei Kuo, Steven T. Rosen, John Burnett, Guido Marcucci, Vinod Pullarkat, Le Xuan Truong Nguyen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6568 (2022)
Venetoclax (VEN) in combination with hypomethylating agents induces disease remission in patients with de novo AML, however, most patients eventually relapse. AML relapse is attributed to the persistence of drug-resistant leukemia stem cells (LSCs).
Externí odkaz:
https://doaj.org/article/92c695ef54d44e219c2297bb7f79b30e
Akademický článek
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