Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Arsen Gaisin"'
Autor:
Sadia Samer, Yanique Thomas, Mariluz Araínga, Crystal Carter, Lisa M. Shirreff, Muhammad S. Arif, Juan M. Avita, Ines Frank, Michael D. McRaven, Christopher T. Thuruthiyil, Veli B. Heybeli, Meegan R. Anderson, Benjamin Owen, Arsen Gaisin, Deepanwita Bose, Lacy M. Simons, Judd F. Hultquist, James Arthos, Claudia Cicala, Irini Sereti, Philip J. Santangelo, Ramon Lorenzo-Redondo, Thomas J. Hope, Francois J. Villinger, Elena Martinelli
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2023)
TGF-β plays a critical role in maintaining immune cells in a resting state by inhibiting cell activation and proliferation. Resting HIV-1 target cells represent the main cellular reservoir after long-term antiretroviral therapy (ART). We hypothesize
Externí odkaz:
https://doaj.org/article/d91bfe3dac314d9ab922f0f232b2155b
Autor:
Meghan J. Orr, Andrew B. Cao, Charles Tiancheng Wang, Arsen Gaisin, Adam Csakai, Alec P. Friswold, Herbert Y. Meltzer, John D. McCorvy, Karl A. Scheidt
Publikováno v:
ACS Med Chem Lett
[Image: see text] The serotonin 5-HT(2) receptors are important pharmaceutical targets involved in signaling pathways underlying various neurological, psychiatric, and cardiac functions and dysfunctions. As such, numerous ligands for the investigatio
Autor:
Mitsuyo Matsumoto, Dmitry M. Hushpulian, Manuj Ahuja, Otis C. Attucks, Young Hoon Ahn, Arsen Gaisin, Erin McDade, S. Sharma, Irina G. Gazaryan, Bobby Thomas, Kazuhiko Igarashi, Masayuki Yamamoto, Sergey Nikulin, Navneet Ammal Kaidery, Irina N. Gaisina, Andrey A. Poloznikov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The Keap1-Nrf2 signaling pathway is a promising therapeutic target for Parkinson’s disease (PD). Canonical Nrf2 activators targeting Keap1 thiols are known to be preventive but never effectively cure chronic neurodegeneration because o
Autor:
Dmitry M. Hushpulian, Eliot H. Kazakov, Bobby Thomas, Irina N. Gaisina, Irina G. Gazaryan, Manuj Ahuja, Arsen Gaisin, Navneet Ammal Kaidery, Andrey A. Poloznikov, Gregory R. J. Thatcher
Publikováno v:
Neurochem Int
Aspirin is a desired leaving group in prodrugs aimed at treatment of neurodegeneration and other conditions. A library of aspirin derivatives of various scaffolds potentially activating Nrf2 has been tested in Neh2-luc reporter assay which screens fo
Autor:
Bobby Thomas, Navneet Ammal Kaidery, Manuj Ahuja, Gregory R. J. Thatcher, Sergey Nikulin, Sue H. Lee, Andrey A. Poloznikov, Natalya N. Smirnova, Irina G. Gazaryan, Sushama Wakade, Megan W. Bourassa, Rajiv R. Ratan, Manel Ben Aissa, Irina N. Gaisina, Arsen Gaisin
Publikováno v:
ACS chemical neuroscience. 9(5)
Activation of HIF-1α and Nrf2 is a primary component of cellular response to oxidative stress, and activation of HIF-1α and Nrf2 provides neuroprotection in models of neurodegenerative disorders, including ischemic stroke, Alzheimer’s and Parkins
Autor:
Manuj Ahuja, Bobby Thomas, Rajiv R. Ratan, N. A. Smirnova, Irina G. Gazaryan, Wendy B. Bollag, Noel Y. Calingasan, Lichuan Yang, M. Flint Beal, Irina N. Gaisina, Arsen Gaisin, John C. Morgan, Dmitry M. Hushpulian, Ismail Kaddour-Djebbar, Navneet Ammal Kaidery, Anatoly A. Starkov
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(23)
A promising approach to neurotherapeutics involves activating the nuclear-factor-E2-related factor 2 (Nrf2)/antioxidant response element signaling, which regulates expression of antioxidant, anti-inflammatory, and cytoprotective genes. Tecfidera, a p
Autor:
Giulio Vistoli, Patrick M. Giguère, Wei Lv, William C. Wetsel, Jianjun Cheng, Claire M. Schmerberg, Alan P. Kozikowski, Hendra Gunosewoyo, Bryan L. Roth, Ramona M. Rodriguiz, Arsen Gaisin, Vladimir M. Pogorelov, Oluseye K. Onajole
Publikováno v:
Journal of medicinal chemistry. 58(4)
The discovery of a new series of compounds that are potent, selective 5-HT2C receptor agonists is described herein as we continue our efforts to optimize the 2-phenylcyclopropylmethylamine scaffold. Modifications focused on the alkoxyl substituent pr