Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Arsalan U Syed"'
Autor:
Maria Paz Prada, Arsalan U Syed, Olivia R Buonarati, Gopireddy R Reddy, Matthew A Nystoriak, Debapriya Ghosh, Sergi Simó, Daisuke Sato, Kent C Sasse, Sean M Ward, Luis F Santana, Yang K Xiang, Johannes W Hell, Madeline Nieves-Cintrón, Manuel F Navedo
Publikováno v:
eLife, Vol 8 (2019)
Elevated glucose increases vascular reactivity by promoting L-type CaV1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a Gs-coupled P2Y receptor is an upstream activator of PKA med
Externí odkaz:
https://doaj.org/article/834ddbe5b2af4b2d9cbfe39b3182cbe7
Autor:
Victor A. Flores‐Tamez, Miguel Martín‐Aragón Baudel, Junyoung Hong, Jade L. Taylor, Lu Ren, Thanhmai Le, Arsalan U. Syed, Yumna Moustafa, Navid Singhrao, Wendy R. Lemus‐Martinez, Gopireddy R. Reddy, Victoria Ramer, Kwun Nok Mimi Man, Peter Bartels, Ye Chen‐Izu, Chao‐Yin Chen, Sergi Simo, Eamonn J. Dickson, Stefano Morotti, Eleonora Grandi, L. Fernando Santana, Johannes W. Hell, Mary C. Horne, Madeline Nieves‐Cintrón, Manuel F. Navedo
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 20 (2024)
Background Increased vascular CaV1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling. Yet, the mechanisms underlying these changes are unclear. We hypothe
Externí odkaz:
https://doaj.org/article/3442030d4e57470fb2eaf2e11402d37c
Autor:
Randi-Michelle Cowin, Nghiem Bui, Deanna Graham, Jennie R Green, Stephan Grueninger, Lisa A Yuva-Paylor, Arsalan U Syed, Andreas Weiss, Richard Paylor
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28409 (2011)
In the present study we report on the use of speed congenics to generate a C57BL/6J congenic line of HD-model R6/2 mice carrying 110 CAG repeats, which uniquely exhibits minimal intergenerational instability. We also report the first identification o
Externí odkaz:
https://doaj.org/article/bd5678873d0346399ed7e86622ea635b
Autor:
Maria Paz Prada, Arsalan U. Syed, Gopireddy R. Reddy, Miguel Martín-Aragón Baudel, Víctor A. Flores-Tamez, Kent C. Sasse, Sean M. Ward, Padmini Sirish, Nipavan Chiamvimonvat, Peter Bartels, Eamonn J. Dickson, Johannes W. Hell, John D. Scott, Luis F. Santana, Yang K. Xiang, Manuel F. Navedo, Madeline Nieves-Cintrón
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Molecular mechanisms by which glucose modulates L-type Ca2+ channel activity and vascular reactivity are unclear. Here the authors report a nanocomplex orchestrated by AKAP5 that facilitates local purinergic stimulation of L-type Ca2+ channels and va
Externí odkaz:
https://doaj.org/article/16c1bd62635d42608c4af12cd7cb45a7
Autor:
Lawrence Huang, Feng Cheng, Xuetao Zhang, Jacek Zielonka, Matthew A. Nystoriak, Weiwei Xiang, Kunal Raygor, Shaoxun Wang, Aditya Lakshmanan, Weiya Jiang, Sai Yuan, Kevin S. Hou, Jiayi Zhang, Xitao Wang, Arsalan U. Syed, Matea Juric, Takamune Takahashi, Manuel F. Navedo, Rong A. Wang
Publikováno v:
Science advances, vol 9, iss 21
Mechanisms underlying arteriovenous malformations (AVMs) are poorly understood. Using mice with endothelial cell (EC) expression of constitutively active Notch4 (Notch4* EC ), we show decreased arteriolar tone in vivo during brain AVM initiation. Red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739e8cfdac82aba13118a0755b8d7fd5
https://escholarship.org/uc/item/4dn6d0gq
https://escholarship.org/uc/item/4dn6d0gq
Autor:
Miguel Martín-Aragón Baudel, Peter Bartels, Madeline Nieves-Cintrón, Víctor A. Flores-Tamez, Kent C. Sasse, Nipavan Chiamvimonvat, Johannes W. Hell, G. R. Reddy, John D. Scott, Luis Fernando Santana, Arsalan U. Syed, Eamonn J. Dickson, Maria Paz Prada, Sean M. Ward, Padmini Sirish, Yang Kevin Xiang, Manuel F. Navedo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
The L-type Ca2+ channel CaV1.2 is essential for arterial myocyte excitability, gene expression and contraction. Elevations in extracellular glucose (hyperglycemia) potentiate vascular L-type Ca2+ channel via PKA, but the underlying mechanisms are unc
Autor:
Shiyue Pan, Junyoung Hong, Navid Singhrao, Madeline Nieves-Cintrón, Kent E. Pinkerton, Arsalan U. Syed, Abby E Burns, Thanhmai Le, Miguel Martín-Aragón Baudel, Kwun Nok Mimi Man, Emma Karey, Chao-Yin Chen, Johannes W. Hell, Víctor A. Flores-Tamez
Publikováno v:
Function (Oxford, England), vol 2, iss 5
Function (Oxford, England)
Function (Oxford, England)
Cigarette smoke, including secondhand smoke (SHS), has significant detrimental vascular effects, but its effects on myogenic tone of small resistance arteries and the underlying mechanisms are understudied. Although it is apparent that SHS contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469b57528c60b55381310b55dceb41a9
https://escholarship.org/uc/item/0bv4p8fz
https://escholarship.org/uc/item/0bv4p8fz
Autor:
Eleonora Grandi, Maria Paz Prada, Nipavan Chiamvimonvat, Stefano Morotti, Manuel F. Navedo, Debapriya Ghosh, Johannes W. Hell, Madeline Nieves-Cintrón, Luis Fernando Santana, Matthew A. Nystoriak, G. R. Reddy, Arsalan U. Syed, Padmini Sirish, Yang Kevin Xiang
Publikováno v:
The Journal of clinical investigation, vol 129, iss 8
Elevated blood glucose (hyperglycemia) is a hallmark metabolic abnormality in diabetes. Hyperglycemia is associated with protein kinase A–dependent (PKA-dependent) stimulation of L-type Ca(2+) channels in arterial myocytes resulting in increased va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1c0b14e17396453f7389d4b42c6bb0
https://europepmc.org/articles/PMC6668679/
https://europepmc.org/articles/PMC6668679/
Autor:
Madeline Nieves-Cintrón, Kent C. Sasse, Johannes W. Hell, Olivia R. Buonarati, Arsalan U. Syed, Matthew A. Nystoriak, Maria Paz Prada, Manuel F. Navedo, Yang Kevin Xiang, Luis Fernando Santana, G. R. Reddy, Daisuke Sato, Debapriya Ghosh, Sean M. Ward, Sergi Simó
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Elevated glucose increases vascular reactivity by promoting L-type CaV1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a Gs-coupled P2Y receptor is an upstream activator of PKA med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d77831ce42e5c1f9ce7a024da6a9cd3
https://escholarship.org/uc/item/52w010dw
https://escholarship.org/uc/item/52w010dw