Functional interdependence of BRD4 and DOT1L in MLL leukemia

Autor: Gilan, O, Lam, EYN, Becher, I, Lugo, D, Cannizzaro, E, Joberty, G, Ward, A, Wiese, M, Fong, CY, Ftouni, S, Tyler, D, Stanley, K, MacPherson, L, Weng, C-F, Chan, Y-C, Ghisi, M, Smil, D, Carpenter, C, Brown, P, Garton, N, Blewitt, ME, Bannister, AJ, Kouzarides, T, Huntly, BJP, Johnstone, RW, Drewes, G, Dawson, S-J, Arrowsmith, CH, Grandi, P, Prinjha, RK, Dawson, MA

Targeted therapies against disruptor of telomeric silencing 1-like (DOT1L) and bromodomain-containing protein 4 (BRD4) are currently being evaluated in clinical trials. However, the mechanisms by which BRD4 and DOT1L regulate leukemogenic transcripti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd41bdeee106695c6be2455010c50f8f

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein.

Autor: Li F; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Ackloo S; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2C4, Canada., Ban F; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Barden CJ; Treventis Corporation, Toronto, Ontario M5T 0S8, Canada.; University Health Network, Toronto, Ontario M5G 2C4, Canada., Beck H; Bayer AG, Drug Discovery Sciences, 42096 Wuppertal, Germany., Beránek J; Department of Biochemistry and Microbiology, University of Chemistry and Technology, Technická 5, 16628 Prague Czech Republic., Berenger F; Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwa-no-ha, Kashiwa, Chiba 277-8561, Japan., Bolotokova A; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Bret G; Laboratoire d'innovation thérapeutique, UMR7200 CNRS-Université de Strasbourg, F-67400 Illkirch, France., Breznik M; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Carosati E; Department of Chemical and Pharmaceutical Sciences, University of Trieste, 34127 Trieste, Italy., Chau I; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Chen Y; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Cherkasov A; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Corte DD; Department of Physics and Astronomy, Brigham Young University, Provo, Utah 84602, United States., Denzinger K; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Dong A; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Draga S; Virtual Discovery, Inc., Boston, Massachusetts 02108, United States.; Non-Governmental Research Organization Biologic, 14 Schitului Street, Bucharest 032044, Romania., Dunn I; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States., Edfeldt K; Structural Genomics Consortium, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, 171 76 Stockholm, Sweden., Edwards A; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Conscience Medicines Network, Toronto, Ontario M5G 1L7 Canada., Eguida M; Laboratoire d'innovation thérapeutique, UMR7200 CNRS-Université de Strasbourg, F-67400 Illkirch, France., Eisenhuth P; Institute for Drug Discovery, Medical Faculty, Leipzig University, Leipzig, Saxony 04103, Germany.; Center for Scalable Data Analytics and Artificial Intelligence, Leipzig University, Leipzig, Saxony 04105, Germany., Friedrich L; Computational Drug Design, Merck KGaA, 64293 Darmstadt Germany., Fuerll A; Institute for Drug Discovery, Medical Faculty, Leipzig University, Leipzig, Saxony 04103, Germany., Gardiner SS; Department of Physics and Astronomy, Brigham Young University, Provo, Utah 84602, United States., Gentile F; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, K1H 8M5 Ottawa, Ontario Canada., Ghiabi P; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Gibson E; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Glavatskikh M; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Gorgulla C; St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.; Department of Physics, Harvard University, Cambridge, Massachusetts 02138, United States., Guenther J; Bayer AG, Drug Discovery Sciences, 13353 Berlin, Germany., Gunnarsson A; Structure and Biophysics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, Mölndal 431 50, Sweden., Gusev F; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States., Gutkin E; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States., Halabelian L; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Harding RJ; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Hillisch A; UCB BioSciences GmbH, 40789 Monheim am Rhein, Germany., Hoffer L; Drug Discovery, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada., Hogner A; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, 431 50 Gothenburg Sweden., Houliston S; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2C4, Canada., Irwin JJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, United States., Isayev O; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States., Ivanova A; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 5, 77900 Olomouc Czech Republic., Jacquemard C; Laboratoire d'innovation thérapeutique, UMR7200 CNRS-Université de Strasbourg, F-67400 Illkirch, France., Jarrett AJ; Department of Physics and Astronomy, Brigham Young University, Provo, Utah 84602, United States., Jensen JH; Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark., Kireev D; Department of Chemistry, University of Missouri, Columbia, Missouri 65211-7600, United States., Kleber J; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Koby SB; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States., Koes D; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States., Kumar A; Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan., Kurnikova MG; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States., Kutlushina A; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 5, 77900 Olomouc Czech Republic., Lessel U; Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany., Liessmann F; Institute for Drug Discovery, Medical Faculty, Leipzig University, Leipzig, Saxony 04103, Germany., Liu S; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Lu W; Galixir Technologies, 200100 Shanghai, China., Meiler J; Institute for Drug Discovery, Medical Faculty, Leipzig University, Leipzig, Saxony 04103, Germany.; Center for Scalable Data Analytics and Artificial Intelligence, Leipzig University, Leipzig, Saxony 04105, Germany.; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37235, United States., Mettu A; Department of Chemistry, University of Missouri, Columbia, Missouri 65211-7600, United States., Minibaeva G; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 5, 77900 Olomouc Czech Republic., Moretti R; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37235, United States., Morris CJ; Department of Physics and Astronomy, Brigham Young University, Provo, Utah 84602, United States., Narangoda C; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States., Noonan T; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Obendorf L; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Pach S; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Pandit A; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Perveen S; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Poda G; Drug Discovery, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada., Polishchuk P; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Hnevotinska 5, 77900 Olomouc Czech Republic., Puls K; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Pütter V; Nuvisan ICB GmBH, 89231 Neu-Ulm, Germany., Rognan D; Laboratoire d'innovation thérapeutique, UMR7200 CNRS-Université de Strasbourg, F-67400 Illkirch, France., Roskams-Edris D; Conscience Medicines Network, Toronto, Ontario M5G 1L7 Canada., Schindler C; Computational Drug Design, Merck KGaA, 64293 Darmstadt Germany., Sindt F; Laboratoire d'innovation thérapeutique, UMR7200 CNRS-Université de Strasbourg, F-67400 Illkirch, France., Spiwok V; Department of Biochemistry and Microbiology, University of Chemistry and Technology, Technická 5, 16628 Prague Czech Republic., Steinmann C; Department of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220, Aalborg, Denmark., Stevens RL; Department of Computer Science, University of Chicago, Chicago, Illinois 60637, United States.; Argonne National Laboratory, Lemont, Illinois 60439, United States., Talagayev V; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Tingey D; Department of Physics and Astronomy, Brigham Young University, Provo, Utah 84602, United States., Vu O; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37235, United States., Walters WP; Relay Therapeutics, Cambridge, Massachusetts 02141, United States., Wang X; Department of Chemistry, University of Missouri, Columbia, Missouri 65211-7600, United States., Wang Z; Galixir Technologies, 200100 Shanghai, China.; Global Institute of Future Technology, Shanghai Jiao Tong University, 200240 Shanghai, China., Wolber G; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Wolf CA; Computational Molecular Design, Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luisestr. 2 + 4, 14195 Berlin, Germany., Wortmann L; Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany., Zeng H; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Zepeda CA; Treventis Corporation, Toronto, Ontario M5T 0S8, Canada., Zhang KYJ; Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan., Zhang J; Galixir Technologies, 200100 Shanghai, China., Zheng S; Global Institute of Future Technology, Shanghai Jiao Tong University, 200240 Shanghai, China., Schapira M; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2024 Nov 25; Vol. 64 (22), pp. 8521-8536. Date of Electronic Publication: 2024 Nov 05.

Discovery of CHD1 Antagonists for PTEN-Deficient Prostate Cancer.

Autor: Johnson RL; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Graboski AL; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Li F; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada., Norris-Drouin JL; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Walton WG; Departments of Chemistry, Biochemistry & Biophysics, and Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Redinbo MR; Departments of Chemistry, Biochemistry & Biophysics, and Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Frye SV; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., James LI; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Nov 07. Date of Electronic Publication: 2024 Nov 07.

Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways.

Autor: Feng S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. shengrui.feng@uhn.ca.; The First Affiliated Hospital of University of South China, Hengyang, Hunan, China. shengrui.feng@uhn.ca., Marhon SA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Sokolowski DJ; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada., D'Costa A; Department of Computer Science, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., Soares F; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Mehdipour P; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ishak C; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Loo Yau H; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Ettayebi I; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Patel PS; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Chen R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Liu J; The Cardiac Development and Early Intervention Unit, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, China., Zuzarte PC; Ontario Institute for Cancer Research, Toronto, ON, Canada., Ho KC; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada., Ho B; Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Ning S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Huang A; The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada.; Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Arrowsmith CH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Wilson MD; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada., Simpson JT; Department of Computer Science, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., De Carvalho DD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. daniel.decarvalho@uhnresearch.ca.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. daniel.decarvalho@uhnresearch.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 29; Vol. 15 (1), pp. 9321. Date of Electronic Publication: 2024 Oct 29.

Poly ADP-ribose signaling is dysregulated in Huntington disease.

Autor: Maiuri T; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada., Bazan CB; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada., Harding RJ; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto ON M5S 3M2, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada., Begeja N; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada., Kam TI; Neurodegeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Byrne LM; University College London Huntington Disease Centre, University College London Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom., Rodrigues FB; University College London Huntington Disease Centre, University College London Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom., Warner MM; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada., Neuman K; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada., Mansoor M; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada., Badiee M; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205., Dasovich M; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205., Wang K; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., Thompson LM; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92868., Leung AKL; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.; Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.; Department of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205., Andres SN; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada., Wild EJ; University College London Huntington Disease Centre, University College London Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom., Dawson TM; Neurodegeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Dawson VL; Neurodegeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 1L7, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Truant R; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct; Vol. 121 (40), pp. e2318098121. Date of Electronic Publication: 2024 Sep 27.