Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice.

Autor: Alves M; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Gil B; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Villegas-Salmerón J; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland; The SFI Centre for Research Training in Genomics Data Science, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Salari V; Department of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, 37134 Verona, Italy., Martins-Ferreira R; Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), 08916 Badalona, Barcelona, Spain; Immunogenetics Laboratory, Molecular Pathology and Immunology, Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Autoimmunity and Neuroscience Group, UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal; ITR - Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal., Arribas Blázquez M; Department of Pharmacology and Toxicology, Veterinary Faculty, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain., Menéndez Méndez A; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; Department of Medicine, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, 28670, Villaviciosa de Odon, Spain., Da Rosa Gerbatin R; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Smith J; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., de Diego-Garcia L; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; Ocupharm Research Group, Faculty of Optics and Optometry, Complutense University of Madrid, Avda. Arcos de Jalon, 118 (28037), Madrid, Spain., Conte G; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Sierra-Marquez J; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Laboratorio Cajal de Circuitos Corticales (CTB), Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Campus Montegancedo S/N, Pozuelo de Alarcon, 28223 Madrid, Spain; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid 28002, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid 28031, Spain., Merino Serrais P; Laboratorio Cajal de Circuitos Corticales (CTB), Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Campus Montegancedo S/N, Pozuelo de Alarcon, 28223 Madrid, Spain., Mitra M; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Fernandez Martin A; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Wang Y; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China., Kesavan J; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Melia C; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; VivoArchitect, Route de la Corniche 5, 1066 Epalinges, Vaud, Switzerland., Parras A; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Beamer E; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; School of Science and Technology, Nottingham Trent University, Nottingham, UK., Zimmer B; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Heiland M; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Cavanagh B; Cellular and Molecular Imaging Core, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland., Parcianello Cipolat R; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Morgan J; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, M13 9PL, UK., Teng X; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China., Prehn JHM; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Fabene PF; Department of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, 37134 Verona, Italy; Section of Anatomy and Histology, Department of Neurosciences, Biomedicine, and Movement Science, Faculty of Medicine, University of Verona, Verona, Italy; Section of Innovation Biomedicine, Department of Engineering for Innovation Medicine, Faculty of Medicine, University of Verona, Verona, Italy., Bertini G; Department of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, 37134 Verona, Italy., Artalejo AR; Department of Pharmacology and Toxicology, Veterinary Faculty, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain., Ballestar E; Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), 08916 Badalona, Barcelona, Spain; Epigenetics in Inflammatory and Metabolic Diseases Laboratory, Health Science Center (HSC), East China Normal University (ECNU), Shanghai 200241, China., Nicke A; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Olivos-Oré LA; Department of Pharmacology and Toxicology, Veterinary Faculty, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain., Connolly NMC; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Henshall DC; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Engel T; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland. Electronic address: tengel@rcsi.ie.

Publikováno v: Brain, behavior, and immunity [Brain Behav Immun] 2024 Aug; Vol. 120, pp. 121-140. Date of Electronic Publication: 2024 May 20.

IQM-PC332, a Novel DREAM Ligand with Antinociceptive Effect on Peripheral Nerve Injury-Induced Pain.

Autor: Socuéllamos PG; Department of Pharmacology and Toxicology, Veterinary Faculty and Instituto Universitario de Investigación en Neuroquímica (IUIN), Universidad Complutense de Madrid, 28040 Madrid, Spain.; Instituto de Investigaciones Biomédicas Alberto Sols (IIBM), CSIC-UAM, 28029 Madrid, Spain., Olivos-Oré LA; Department of Pharmacology and Toxicology, Veterinary Faculty and Instituto Universitario de Investigación en Neuroquímica (IUIN), Universidad Complutense de Madrid, 28040 Madrid, Spain.; Instituto de Investigación Sanitaria San Carlos, 28040 Madrid, Spain., Barahona MV; Department of Pharmacology and Toxicology, Veterinary Faculty and Instituto Universitario de Investigación en Neuroquímica (IUIN), Universidad Complutense de Madrid, 28040 Madrid, Spain.; Instituto de Investigación Sanitaria San Carlos, 28040 Madrid, Spain., Cercós P; Instituto de Química Médica (IQM-CSIC), 28006 Madrid, Spain., Pérez Pascual M; Department of Pharmacology and Toxicology, Veterinary Faculty and Instituto Universitario de Investigación en Neuroquímica (IUIN), Universidad Complutense de Madrid, 28040 Madrid, Spain., Arribas-Blázquez M; Department of Pharmacology and Toxicology, Veterinary Faculty and Instituto Universitario de Investigación en Neuroquímica (IUIN), Universidad Complutense de Madrid, 28040 Madrid, Spain.; Instituto de Investigación Sanitaria San Carlos, 28040 Madrid, Spain., Naranjo JR; Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain., Valenzuela C; Instituto de Investigaciones Biomédicas Alberto Sols (IIBM), CSIC-UAM, 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain., Gutiérrez-Rodríguez M; Instituto de Química Médica (IQM-CSIC), 28006 Madrid, Spain., Artalejo AR; Department of Pharmacology and Toxicology, Veterinary Faculty and Instituto Universitario de Investigación en Neuroquímica (IUIN), Universidad Complutense de Madrid, 28040 Madrid, Spain.; Instituto de Investigación Sanitaria San Carlos, 28040 Madrid, Spain.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Feb 15; Vol. 23 (4). Date of Electronic Publication: 2022 Feb 15.

Molecular Alterations in Sporadic and SOD1 -ALS Immortalized Lymphocytes: Towards a Personalized Therapy.

Autor: Lastres-Becker I; Instituto de Investigaciones Biomédicas 'Alberto Sols' UAM-CSIC, Arturo Duperier 4, 28029 Madrid, Spain.; Department of Biochemistry, School of Medicine, Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain.; Institute Teófilo Hernando for Drug Discovery, Universidad Autónoma de Madrid, 28029 Madrid, Spain., Porras G; Centro de Investigaciones Biológicas-CSIC, Avd, Ramiro Maetzu 9, 28031 Madrid, Spain., Arribas-Blázquez M; Instituto de Investigaciones Biomédicas 'Alberto Sols' UAM-CSIC, Arturo Duperier 4, 28029 Madrid, Spain.; Department of Biochemistry, School of Medicine, Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain., Maestro I; Centro de Investigaciones Biológicas-CSIC, Avd, Ramiro Maetzu 9, 28031 Madrid, Spain., Borrego-Hernández D; ALS Unit, Hospital 12 de Octubre Research Institute (i+12), 28041 Madrid, Spain., Boya P; Centro de Investigaciones Biológicas-CSIC, Avd, Ramiro Maetzu 9, 28031 Madrid, Spain., Cerdán S; Instituto de Investigaciones Biomédicas 'Alberto Sols' UAM-CSIC, Arturo Duperier 4, 28029 Madrid, Spain., García-Redondo A; ALS Unit, Hospital 12 de Octubre Research Institute (i+12), 28041 Madrid, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain., Martínez A; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain.; Centro de Investigaciones Biológicas-CSIC, Avd, Ramiro Maetzu 9, 28031 Madrid, Spain., Martin-Requero Á; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain.; Centro de Investigaciones Biológicas-CSIC, Avd, Ramiro Maetzu 9, 28031 Madrid, Spain.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 16; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 16.

Modulating voltage-gated sodium channels to enhance differentiation and sensitize glioblastoma cells to chemotherapy.

Autor: Giammello, Francesca^1,2 (AUTHOR), Biella, Chiara³ (AUTHOR), Priori, Erica Cecilia¹ (AUTHOR), Filippo, Matilde Amat Di San⁴ (AUTHOR), Leone, Roberta¹ (AUTHOR), D'Ambrosio, Francesca⁴ (AUTHOR), Paterno', Martina⁴ (AUTHOR), Cassioli, Giulia⁴ (AUTHOR), Minetti, Antea⁵ (AUTHOR), Macchi, Francesca⁵ (AUTHOR), Spalletti, Cristina⁵ (AUTHOR), Morella, Ilaria¹ (AUTHOR), Ruberti, Cristina⁶ (AUTHOR), Tremonti, Beatrice⁷ (AUTHOR), Barbieri, Federica⁷ (AUTHOR), Lombardi, Giuseppe⁸ (AUTHOR), Brambilla, Riccardo¹ (AUTHOR), Florio, Tullio^7,9 (AUTHOR), Galli, Rossella³ (AUTHOR), Rossi, Paola¹ (AUTHOR)

Publikováno v: Cell Communication & Signaling. 9/9/2024, Vol. 22 Issue 1, p1-28. 28p.

MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus.

Autor: Beamer EH; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Jurado-Arjona J; Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.; Department of Molecular Biology, Centro de Biología Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Centro Investigación Biomédica en Red Enfermedades Neurodegenerativa (CIBERNED), Madrid, Spain., Jimenez-Mateos EM; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Morgan J; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Reschke CR; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; FutureNeuro Research Centre, RCSI, Dublin, Ireland., Kenny A; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., de Leo G; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Olivos-Oré LA; Department of Pharmacology and Toxicology, Veterinary Faculty, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense de Madrid, Madrid, Spain., Arribas-Blázquez M; Department of Pharmacology and Toxicology, Veterinary Faculty, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense de Madrid, Madrid, Spain., Madden SF; Data Science Centre, Royal College of Surgeons in Ireland, Dublin, Ireland., Merchán-Rubira J; Department of Molecular Biology, Centro de Biología Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Centro Investigación Biomédica en Red Enfermedades Neurodegenerativa (CIBERNED), Madrid, Spain., Delanty N; FutureNeuro Research Centre, RCSI, Dublin, Ireland.; Beaumont Hospital, Dublin, Ireland., Farrell MA; Beaumont Hospital, Dublin, Ireland., O'Brien DF; Beaumont Hospital, Dublin, Ireland., Avila J; Department of Molecular Biology, Centro de Biología Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Centro Investigación Biomédica en Red Enfermedades Neurodegenerativa (CIBERNED), Madrid, Spain., Diaz-Hernandez M; Department of Biochemistry and Molecular Biology, Veterinary Faculty, Universidad Complutense de Madrid, Madrid, Spain., Miras-Portugal MT; Department of Biochemistry and Molecular Biology, Veterinary Faculty, Universidad Complutense de Madrid, Madrid, Spain., Artalejo AR; Department of Pharmacology and Toxicology, Veterinary Faculty, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense de Madrid, Madrid, Spain., Hernandez F; Department of Molecular Biology, Centro de Biología Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Centro Investigación Biomédica en Red Enfermedades Neurodegenerativa (CIBERNED), Madrid, Spain., Henshall DC; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; FutureNeuro Research Centre, RCSI, Dublin, Ireland., Engel T; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; FutureNeuro Research Centre, RCSI, Dublin, Ireland.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2018 Dec 11; Vol. 11, pp. 442. Date of Electronic Publication: 2018 Dec 11 (Print Publication: 2018).