Zobrazeno 1 - 10
of 645
pro vyhledávání: '"Arrestin beta 2"'
Autor:
Zakrzewicz, Anna, Krasteva, Gabriela, Wilhelm, Jochen, Dietrich, Hartmut, Wilker, Sigrid, Padberg, Winfried, Wygrecka, Malgorzata, Grau, Veronika
Publikováno v:
In Immunobiology 2011 216(7):854-861
Autor:
Winfried Padberg, Anna Zakrzewicz, Gabriela Krasteva, Veronika Grau, Sigrid Wilker, Hartmut Dietrich, Malgorzata Wygrecka, Jochen Wilhelm
Publikováno v:
Immunobiology. 216(7)
During acute rejection, numerous pro-inflammatory and cytotoxic monocytes accumulate in the vasculature of experimental renal allografts. Arrestins (ARRBs) are cellular regulators of inflammation, but nothing is known about their expression during re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94faf7e48f172dfe9d01c05a70b747fe
https://pubmed.ncbi.nlm.nih.gov/21193245
https://pubmed.ncbi.nlm.nih.gov/21193245
Akademický článek
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Autor:
Chanjuan Xu, Jiayu Zheng, Yingxuan Wang, Yuhua Liao, Yanzhao Zhou, Zhihua Qiu, Xiaole Yan, Zhiran Fan, Qingchen Yuan, Xiao Chen
Publikováno v:
Biochemical and Biophysical Research Communications. 544:1-7
Background Our previous study developed ATRQβ-001 vaccine, which targets peptide ATR001 from angiotensin Ⅱ (Ang Ⅱ) receptor type 1 (AT1R). The ATRQβ-001 vaccine could induce the production of anti-ATR001 monoclonal antibody (McAb-ATR) and inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebdf22a189634dba9e32deb8ed428ed
https://doi.org/10.1016/j.bbrc.2021.01.054
https://doi.org/10.1016/j.bbrc.2021.01.054
Autor:
Fernando A.C. Seara, Guorui Deng, Justin L. Grobe, Pablo Nakagawa, Curt D. Sigmund, Sadashiva S. Karnik, Natalia M Mathieu, Mario Zanaty, Kirthikaa Balapattabi
Publikováno v:
Hypertension. 77:420-431
Activation of central AT 1 Rs (angiotensin type 1 receptors) is required for the increased blood pressure, polydipsia, and salt intake in deoxycorticosterone acetate (DOCA)–salt hypertension. TRV120027 (TRV027) is an AT 1 R-biased agonist that sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cda514c55bbf5f66d88cbeb8608cd8d
https://doi.org/10.1161/hypertensionaha.120.15793
https://doi.org/10.1161/hypertensionaha.120.15793
Publikováno v:
The Journal of Biological Chemistry
G protein–coupled receptors (GPCRs) initiate signaling cascades via G-proteins and beta-arrestins (βarr). βarr-dependent actions begin with recruitment of βarr to the phosphorylated receptor tail and are followed by engagement with the receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3fca8f534076fed69ccead04aa47ff
https://doi.org/10.1074/jbc.ra120.015400
https://doi.org/10.1074/jbc.ra120.015400
Autor:
Yao Lu, Daisy L Spark, Christopher J. Langmead, Gregory D. Stewart, Cassandra J Hatzipantelis
Publikováno v:
ACS Chemical Neuroscience. 11:2077-2084
The orphan Gαs-coupled receptor GPR52 is expressed exclusively in the brain, predominantly in circuitry relating to symptoms of neuropsychiatric and cognitive disorders such as schizophrenia. While GPR52 agonists have displayed antipsychotic and pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8027b5074d6f1b5471cad7c06a2a6419
https://doi.org/10.1021/acschemneuro.0c00199
https://doi.org/10.1021/acschemneuro.0c00199
Autor:
Karst, Henk, den Boon, Femke S, Vervoort, Niek, Adrian, Max, Kapitein, Lukas C, Joëls, Marian, Sub Cell Biology, Celbiologie
Publikováno v:
Molecular and Cellular Endocrinology, 541, 1. Elsevier Ireland Ltd.
Molecular and Cellular Endocrinology, 541:111501. ELSEVIER IRELAND LTD
Molecular and Cellular Endocrinology, 541:111501. ELSEVIER IRELAND LTD
Corticosteroid receptors in the mammalian brain mediate genomic as well as non-genomic actions. Although receptors mediating genomic actions were already cloned 35 years ago, it remains unclear whether the same molecules are responsible for the non-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5770c29c757d675dbf9321826514bbc4
https://hdl.handle.net/11370/a48b463a-a0e0-43b8-a5ea-0bfa9e0558d2
https://hdl.handle.net/11370/a48b463a-a0e0-43b8-a5ea-0bfa9e0558d2
Autor:
Jordan T. Bateman, Erica S. Levitt
Publikováno v:
Am J Physiol Cell Physiol
Respiratory depression is a potentially fatal side effect of opioid analgesics and a major limitation to their use. G protein-biased opioid agonists have been proposed as “safer” analgesics with less respiratory depression. These agonists are bia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f821491712c2a1d0219460d7be8838ed
https://pubmed.ncbi.nlm.nih.gov/34469203
https://pubmed.ncbi.nlm.nih.gov/34469203
Publikováno v:
Neuropharmacology
G protein-coupled receptors (GPCR) have a long history of being considered a prime target for drug development to treat a plethora of diseases and disorders. In fact in 1827, the first approved therapeutic in the United States was morphine, a drug th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19af1e56bf922568222a2e9080ae719a
https://doi.org/10.1016/j.neuropharm.2018.11.010
https://doi.org/10.1016/j.neuropharm.2018.11.010