Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Arrel D. Toews"'
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 7, Pp 1048-1053 (2000)
We determined the extent to which diurnal variation in cholesterol synthesis in liver is controlled by steady-state mRNA levels for the rate-limiting enzyme in the pathway, hydroxymethylglutaryl (HMG)-CoA reductase. Rats 30 days of age and maintained
Externí odkaz:
https://doaj.org/article/b44746e2d9ca4aba90aef830408bf448
Autor:
Jenny P.-Y. Ting, Vivian S. Chen, James P. Morrison, Willie June Brickey, Glenn K. Matsushima, Denis Gris, Heather A. Iocca, Sushmita Jha, Siddharth Y. Srivastava, Arrel D. Toews
Publikováno v:
The Journal of Neuroscience. 30:15811-15820
Inflammation is increasingly recognized as an important contributor to a host of CNS disorders; however, its regulation in the brain is not well delineated. Nucleotide-binding domain, leucine-rich repeat, pyrin domain containing 3 (NLRP3) is a key co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b86015ecc3a03f1ce40f2215a0873b
https://doi.org/10.1523/jneurosci.4088-10.2010
https://doi.org/10.1523/jneurosci.4088-10.2010
Publikováno v:
Journal of Neurochemistry. 76:77-86
Myelination, during both normal development and with respect to disorders of myelination, is commonly studied by morphological and/or biochemical techniques that assay as their end-points the extent of myelination. The rate of myelination is potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2489c9ebef2e2ce76ae464954042883
https://doi.org/10.1046/j.1471-4159.2001.00015.x
https://doi.org/10.1046/j.1471-4159.2001.00015.x
Autor:
Janell Hostettler, Jeffrey L. Mason, James E. Goldman, Arrel D. Toews, Glenn K. Matsushima, Kinuko Suzuki, Pierre Morell
Publikováno v:
The American Journal of Pathology. 164:1673-1682
To understand mechanisms that may underlie the progression of a demyelinated lesion to a chronic state, we have used the cuprizone model of chronic demyelination. In this study, we investigated the fate of oligodendrocytes during the progression of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63004fcb6aca14fae5f9e2a5bd5c9677
https://doi.org/10.1016/s0002-9440(10)63726-1
https://doi.org/10.1016/s0002-9440(10)63726-1
Autor:
Janell Hostettler, Pierre Morell, Deanne W. Sammond, Helga Jurevics, Arrel D. Toews, Klaus-Armin Nave
Publikováno v:
Journal of Neuroscience Research. 71:826-834
Proteolipid protein (PLP) is the primary protein component of CNS myelin, yet myelin from the PLP n u l l mouse has only minor ultrastructural abnormalities. Might compensation for a potentially unstable structure involveincreased myelin synthesis an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afe3c7f015aa82872d78832388c92fb
https://doi.org/10.1002/jnr.10544
https://doi.org/10.1002/jnr.10544
Publikováno v:
Journal of Neurochemistry. 64:2169-2176
A peripheral neuropathy characterized by a transient demyelinating/remyelinating sequence results when young rats are fed a tellurium-containing diet. The neuropathy occurs secondary to a systemic block in cholesterol synthesis. Squalene accumulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d3cb28ba044ef0b0907887ab263d08
https://doi.org/10.1046/j.1471-4159.1995.64052169.x
https://doi.org/10.1046/j.1471-4159.1995.64052169.x
Publikováno v:
Journal of Neurochemistry. 71:549-555
Cholesterol accounts for over one-fourth of total myelin lipids. We found that, during development of the rat sciatic nerve, expression of mRNA for hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol biosynth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6bcd24e09e2d6013651561a385b153
https://doi.org/10.1046/j.1471-4159.1998.71020549.x
https://doi.org/10.1046/j.1471-4159.1998.71020549.x
Autor:
Helga Jurevics, Janell Hostettler, Deanne W. Sammond, Carrie Largent, Amber M. Kleindienst, Arrel D. Toews, Pierre Morell, Glenn K. Matsushima
Publikováno v:
Journal of Neurochemistry. 82:126-136
Exposure of mice to the copper chelator, cuprizone, results in CNS demyelination. There is remyelination after removal of the metabolic insult. We present brain regional studies identifying corpus callosum as particularly severely affected; 65% of ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50b775d081964b31bf21ddfdb6f02226
https://doi.org/10.1046/j.1471-4159.2002.00954.x
https://doi.org/10.1046/j.1471-4159.2002.00954.x
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 7, Pp 1048-1053 (2000)
We determined the extent to which diurnal variation in cholesterol synthesis in liver is controlled by steady-state mRNA levels for the rate-limiting enzyme in the pathway, hydroxymethylglutaryl (HMG)-CoA reductase. Rats 30 days of age and maintained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bace6c78585099577603c56d3ac17a
https://doi.org/10.1016/s0022-2275(20)32008-3
https://doi.org/10.1016/s0022-2275(20)32008-3
Autor:
Helga Jurevics, Glenn K. Matsushima, C. Largent, Deanne W. Sammond, Pierre Morell, Janell Hostettler, Arrel D. Toews
Publikováno v:
Journal of Neurochemistry. 81:49-51
Exposure of mice to the copper chelator, Cuprizone, results in a CNS demyelination; remyelination occurs following removal of this metabolic insult. Using this model, we have demonstrated changes in content and metabolism of myelin lipids in whole br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1950119584d7beec5bc008b4f8194e
https://doi.org/10.1046/j.1471-4159.81.s1.16_2.x
https://doi.org/10.1046/j.1471-4159.81.s1.16_2.x