Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Arpita Upadhyaya"'
Publikováno v:
eLife, Vol 12 (2023)
Antigen-induced B-cell receptor (BCR) signaling is critical for initiating and regulating B-cell activation. The actin cytoskeleton plays essential roles in BCR signaling. Upon encountering cell-surface antigens, actin-driven B-cell spreading amplifi
Externí odkaz:
https://doaj.org/article/e4b2c0ae34a5410b8a168f0863cce1c7
Autor:
Qin Ni, Kaustubh Wagh, Aashli Pathni, Haoran Ni, Vishavdeep Vashisht, Arpita Upadhyaya, Garegin A Papoian
Publikováno v:
eLife, Vol 11 (2022)
In most eukaryotic cells, actin filaments assemble into a shell-like actin cortex under the plasma membrane, controlling cellular morphology, mechanics, and signaling. The actin cortex is highly polymorphic, adopting diverse forms such as the ring-li
Externí odkaz:
https://doaj.org/article/545608be2de84536ba0c939a1640cd5f
Autor:
Margaret K. Seeley-Fallen, Michelle Lazzaro, Chaohong Liu, Quan-Zhen Li, Arpita Upadhyaya, Wenxia Song
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Antigen (Ag)-triggered B-cell receptor (BCR) signaling initiates antibody responses. However, prolonged or uncontrolled BCR signaling is associated with the development of self-reactive B-cells and autoimmune diseases. We previously showed that actin
Externí odkaz:
https://doaj.org/article/cc57427a9ba4416da2c48ff8e34e3eb3
Autor:
Aashli Pathni, Altuğ Özçelikkale, Ivan Rey-Suarez, Lei Li, Scott Davis, Nate Rogers, Zhengguo Xiao, Arpita Upadhyaya
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cytotoxic T lymphocytes (CTLs) play an integral role in the adaptive immune response by killing infected cells. Antigen presenting cells (APCs), such as dendritic cells, present pathogenic peptides to the T cell receptor on the CTL surface and co-sti
Externí odkaz:
https://doaj.org/article/18c47cf2353d47e8bd6bc3e6214ea529
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/0c1cc890bd0941b290afe73e4978e146
Autor:
Ivan Rey-Suarez, Brittany A. Wheatley, Peter Koo, Anshuman Bhanja, Zhou Shu, Simon Mochrie, Wenxia Song, Hari Shroff, Arpita Upadhyaya
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
B cell receptors (BCR) capture antigen and initiate downstream antibody responses, but whether and how BCR signaling is regulated by BCR mobility is still unclear. Here the authors show, using single molecule imaging and machine learning analyses, th
Externí odkaz:
https://doaj.org/article/2a250cd833d54780bbb3012f5d131e7e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
B-cells undergo somatic hypermutation and affinity maturation in germinal centers. Somatic hypermutated germinal center B-cells (GCBs) compete to engage with and capture antigens on follicular dendritic cells. Recent studies show that when encounteri
Externí odkaz:
https://doaj.org/article/8c15c4e0b62b4f9ca2ee02df8ebc093e
Autor:
Yicong Wu, Abhishek Kumar, Corey Smith, Evan Ardiel, Panagiotis Chandris, Ryan Christensen, Ivan Rey-Suarez, Min Guo, Harshad D. Vishwasrao, Jiji Chen, Jianyong Tang, Arpita Upadhyaya, Patrick J. La Riviere, Hari Shroff
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Light-sheet fluorescence microscopy enables high resolution imaging of biological samples. Here the authors use reflective coverslips to obtain multiple sample views simultaneously, improving the speed of acquisition and resolution compared to dual-v
Externí odkaz:
https://doaj.org/article/c9d70825284743998dcbe927064d2824
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 7, p e1007156 (2019)
Bundled actin structures play a key role in maintaining cellular shape, in aiding force transmission to and from extracellular substrates, and in affecting cellular motility. Recent studies have also brought to light new details on stress generation,
Externí odkaz:
https://doaj.org/article/cbb9b310f1884486a25b6afe8bd11a78
Autor:
Chaohong Liu, Xiaoming Bai, Junfeng Wu, Shruti Sharma, Arpita Upadhyaya, Carin I M Dahlberg, Lisa S Westerberg, Scott B Snapper, Xiaodong Zhao, Wenxia Song
Publikováno v:
PLoS Biology, Vol 11, Iss 11, p e1001704 (2013)
Negative regulation of receptor signaling is essential for controlling cell activation and differentiation. In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) signaling is critical for suppressing the activation of self-reactive B
Externí odkaz:
https://doaj.org/article/115b27f716764bbca176b4121b4bc601