Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Arpita Pawashe"'
Autor:
Lauric Haber, Kara Olson, Marcus P. Kelly, Alison Crawford, David J. DiLillo, Richard Tavaré, Erica Ullman, Shu Mao, Lauren Canova, Olga Sineshchekova, Jennifer Finney, Arpita Pawashe, Supriya Patel, Ryan McKay, Sahar Rizvi, Ermelinda Damko, Danica Chiu, Kristin Vazzana, Priyanka Ram, Katja Mohrs, Amanda D’Orvilliers, Jenny Xiao, Sosina Makonnen, Carlos Hickey, Cody Arnold, Jason Giurleo, Ya Ping Chen, Courtney Thwaites, Drew Dudgeon, Kevin Bray, Ashique Rafique, Tammy Huang, Frank Delfino, Aynur Hermann, Jessica R. Kirshner, Marc W. Retter, Robert Babb, Douglas MacDonald, Gang Chen, William C. Olson, Gavin Thurston, Samuel Davis, John C. Lin, Eric Smith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind to T cells via CD3 and to tumor cells via tumor-cell-specific antigens (TSA), inducing T-cell-mediated killing of tumo
Externí odkaz:
https://doaj.org/article/13db8e3e17e043ffbbadbbb6bb988d63
Autor:
William C. Olson, Alison Crawford, Kara Olson, Jennifer Finney, Ashique Rafique, Kristin Vazzana, Drew Dudgeon, Cody Arnold, Lauren Canova, Eric Smith, Samuel Davis, Gavin Thurston, Ryan McKay, Tammy T. Huang, Danica Chiu, Douglas MacDonald, Sahar Rizvi, Robert Babb, Richard Tavaré, Amanda Dorvilliers, Erica Ullman, Arpita Pawashe, Shu Mao, Ya Ping Chen, Sosina Makonnen, Jenny Xiao, Lauric Haber, Jessica R. Kirshner, Aynur Hermann, Marcus Kelly, Gang Chen, Bray Kevin A, Courtney Thwaites, Carlos Hickey, Olga Sineshchekova, Katja Mohrs, Jason T. Giurleo, Ermelinda Damko, Supriya Patel, John C. Lin, Frank Delfino, Marc W. Retter, Priyanka Ram, Dilillo David
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind to T cells via CD3 and to tumor cells via tumor-cell-specific antigens (TSA), inducing T-cell-mediated killing of tumor cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c594174da440faa66c488c86be8e9c2
https://doaj.org/article/13db8e3e17e043ffbbadbbb6bb988d63
https://doaj.org/article/13db8e3e17e043ffbbadbbb6bb988d63
Autor:
Drew Dudgeon, Xuan Ye, Jacqueline J. Warsaw, Evan Herlihy, Erica Ullman, Arpita Pawashe, William Poueymirou, Patrick Poon, Ilyssa Ramos, Dharani Ajithdoss, Bei Wang, Jacquelynn Golubov, Nicole Stokes Oristian, Eric Smith, Matthew A. Sleeman, George D. Yancopoulos, Rabih Slim, Alison Crawford, Priyanka Ram, William C. Olson, Chia-Jen Siao, Andrew J. Murphy, Hassan Ahmed, Terra Potocky, Janelle C. Waite, Danica Chiu, Gavin Thurston, Dimitris Skokos, Tammy T. Huang, Erin Oswald, Lauren Canova, Adelekan Oyejide, Stephen Godin, Lauren Havel, Kathleen Provoncha, Qi Wu, Douglas MacDonald, Miguel Lazo, Kevin Yu, Joel H. Martin, Ashique Rafique, Kristin Vazzana, John C. Lin, Lauric Haber, Jessica R. Kirshner, Aynur Hermann, Julie Kim
Publikováno v:
Science Translational Medicine. 12
T cell activation is initiated upon binding of the T cell receptor (TCR)/CD3 complex to peptide-major histocompatibility complexes ("signal 1"); activation is enhanced by engagement of a second "costimulatory" receptor, such as the CD28 receptor on T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdeea24fdd9f144f77f6e92ee9ca0bb
https://doi.org/10.1126/scitranslmed.aaw7888
https://doi.org/10.1126/scitranslmed.aaw7888
Autor:
Shao Ning Yang, Rabih Slim, Lauren Canova, Andrew J. Murphy, Macdonald Lynn, Jacqueline J. Warsaw, Cagan Gurer, Erica Ullman, Arpita Pawashe, Lauric Haber, Aynur Hermann, Ilyssa Ramos, Gang Chen, Jennifer Stella, Jacquelynn Golubov, Teresa Schulenburg, George D. Yancopoulos, Joel H. Martin, Jennifer Finney, Dimitris Skokos, Ashique Rafique, Elizabeth Navarro, Matthew A. Sleeman, Elena Garnova, Nicole Stokes Oristian, Robert Babb, Xuan Ye, Randi Foster, Julie Kim, William Poueymirou, Qi Wu, Douglas MacDonald, Hassan Ahmed, William C. Olson, Clarissa Lett, Erin Oswald, Janelle C. Waite, Israel Lowy, Stephen Godin, Eric Smith, Pamela Krueger, Devon Grote, Patrick Poon, John C. Lin, Drew Dudgeon, Evan Herlihy, Bei Wang, Amanda Dorvilliers, Dharani Ajithdoss, Jenny Xiao, Christopher Daly, Vishal Kamat, Gavin Thurston, Chia-Jen Siao
Publikováno v:
Science translational medicine. 12(549)
Monoclonal antibodies that block the programmed cell death 1 (PD-1) checkpoint have revolutionized cancer immunotherapy. However, many major tumor types remain unresponsive to anti-PD-1 therapy, and even among responsive tumor types, most of the pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9e0670c5d21cb293213bc474b8c8f3
https://pubmed.ncbi.nlm.nih.gov/32581132
https://pubmed.ncbi.nlm.nih.gov/32581132
Autor:
Sosina Makonnen, Marc W. Retter, Priyanka Ram, Paurene Duramad, Arpita Pawashe, Elena Garnova, Carlos Hickey, Stephen Godin, Curtis Colleton, Eric Smith, Jessica Kuhnert, Pamela Krueger, Frank Delfino, Sumreen Jalal, Alison Crawford, Gavin Thurston, Danica Chiu, Tammy T. Huang, Terra Potocky, Lauren Canova, Douglas MacDonald, John C. Lin, Jeanette L. Fairhurst, William C. Olson, Marcus Kelly, Joel H. Martin, Jennifer Finney, Kristin Vazzana, Lauric Haber, Jessica R. Kirshner
Publikováno v:
Science Translational Medicine. 11
Advanced ovarian cancer is frequently treated with combination chemotherapy, but high recurrence rates show the need for therapies that can produce durable responses and extend overall survival. Bispecific antibodies that interact with tumor antigens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122f21f84972c4add0582947382ebc2c
https://doi.org/10.1126/scitranslmed.aau7534
https://doi.org/10.1126/scitranslmed.aau7534
Autor:
Aynur Hermann, Gang Chen, Jennifer Finney, Kristin Vazzana, Supriya Patel, Sosina Makonnen, Ya Ping Chen, Lauric Haber, Amanda Dorvilliers, Jessica R. Kirshner, Eric Smith, Robert Babb, Carlos Hickey, Alison Crawford, Jenny Xiao, Jason T. Giurleo, Katja Mohrs, Marcus Kelly, Richard Tavaré, Erica Ullman, Arpita Pawashe, Lauren Canova, Kara Olson, Cody Arnold, Danica Chiu, Marc W. Retter, William C. Olson, Gavin Thurston, Priyanka Ram, Dilillo David, John C. Lin
Publikováno v:
Cancer Research. 80:4555-4555
T-cell redirecting bispecific antibodies are an emerging class of therapeutic agents designed to simultaneously bind to T cells (via CD3) and tumor cell specific antigens (TSA), with the goal of inducing T cell-mediated killing of tumor cells. Despit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92e52136fc46a91b5e3fef0f918a112f
https://doi.org/10.1158/1538-7445.am2020-4555
https://doi.org/10.1158/1538-7445.am2020-4555
Autor:
Carlos Hickey, Kristin Vazzana, Eric Smith, Priyanka Ram, Lauric Haber, Jessica R. Kirshner, Alison Crawford, Sosina Makkonen, Stephen Godin, Gavin Thurston, Curtis Colleton, Marcus Kelly, John C. Lin, Lauren Canova, Jennifer Principio, Paurene Duramad, Arpita Pawashe
Publikováno v:
Cancer Research. 78:1777-1777
Advanced ovarian cancer has a high rate of recurrence, thus there is a need for therapies that can produce durable responses and extend overall survival. Infiltrating CD3+ T cells are reported to correlate with improved clinical outcome in stage III/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c2f837361c2fbc2951107189ec3bc5a
https://doi.org/10.1158/1538-7445.am2018-1777
https://doi.org/10.1158/1538-7445.am2018-1777