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pro vyhledávání: '"Arpita P. Pawashe"'
Publikováno v:
Frontiers in Biology. 11:366-375
Background Cancer immunotherapy uses one’s own immune system to fight cancerous cells. As immune system is hard-wired to distinguish self and non-self, cancer immunotherapy is predicted to target cancerous cells specifically, therefore is less toxi
Autor:
Jorge Duitama, Brian M. Baker, Steven A. Corcelli, Pramod K. Srivastava, Ion I. Mandoiu, Alessandro Sette, Tatiana Blanchard, Sahar Al Seesi, Cory M. Ayres, David McMahon, Arpita P. Pawashe, John Sidney, Fei Duan
Publikováno v:
The Journal of Experimental Medicine
Srivastava et al. define a new and improved way to predict immunoprotective cancer neoepitopes based in part on the difference in MHC-binding scores between the mutant epitope and its wild-type counterpart. Remarkably, all neoepitopes that elicited t