Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Arpit Doshi"'
Autor:
Farhana Islam, Arpit Doshi, Andrew J. Robles, Tasdique M. Quadery, Xin Zhang, Xilin Zhou, Ernest Hamel, Susan L. Mooberry, Aleem Gangjee
Publikováno v:
Molecules, Vol 27, Iss 1, p 321 (2022)
A series of eleven 4-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines were designed and synthesized and their biological activities were evaluated. Synthesis involved the Gewald reaction to synthesize ethyl 2-amino-4,5,6,7-tetrahydrob
Externí odkaz:
https://doaj.org/article/7e14f2f7c8c3494e8171cf9f1f985b53
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Supplementary Method Descriptions Molecular modeling and computational studies Enzyme expression and purification. In vitro enzymatic assays and Ki determinations In vivo efficacy trials with MIA PaCa-2 pancreatic cancer xenografts. Cytochrome c oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc08fe908fb7939bc9f8ad0ffe9cbc1
https://doi.org/10.1158/1535-7163.22505520
https://doi.org/10.1158/1535-7163.22505520
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria and cytosol and supports cell growth through nucleotide and amino acid biosynthesis. Mitochondrial C1 metabolism, including serine hydroxymethyltransferase (SHMT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4253307c713eb35fa04c2ec4fe8823be
https://doi.org/10.1158/1535-7163.c.6538104.v1
https://doi.org/10.1158/1535-7163.c.6538104.v1
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Supplementary Figure S1 shows in vitro antiproliferative activity and targeted pathways of previously reported AICARFTase and GARFTase inhibitors. Supplementary Figure S2 shows docking of AGF291, AGF320, and AGF347 (along with 5-formyl-THF) in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f58160726ffe67fe411c78ec2698b22
https://doi.org/10.1158/1535-7163.22505523.v1
https://doi.org/10.1158/1535-7163.22505523.v1
Autor:
Aamod S. Dekhne, Khushbu Shah, Gregory S. Ducker, Jade M. Katinas, Jennifer Wong-Roushar, Md. Junayed Nayeen, Arpit Doshi, Changwen Ning, Xun Bao, Josephine Frühauf, Jenney Liu, Adrianne Wallace-Povirk, Carrie O'Connor, Sijana H. Dzinic, Kathryn White, Juiwanna Kushner, Seongho Kim, Maik Hüttemann, Lisa Polin, Joshua D. Rabinowitz, Jing Li, Zhanjun Hou, Charles E. Dann, Aleem Gangjee, Larry H. Matherly
Publikováno v:
Molecular Cancer Therapeutics. 22:287-287
Publikováno v:
The AAPS Journal. 23
The nociceptin opioid receptor (NOP), the fourth member of the opioid receptor family, and its endogenous peptide ligand, nociceptin or orphanin FQ (N/OFQ), play a vital role in several central nervous system pathways regulating pain, reward, feeding
Autor:
Aleem Gangjee, Lerin R. Luckett-Chastain, Ernest Hamel, Shruti Choudhary, Michael A. Ihnat, Arpit Doshi, Susan L. Mooberry
Publikováno v:
Bioorg Med Chem
The efficacy of quinazoline-based antiglioma agents has been attributed to their effects on microtubule dynamics.1,2 The design, synthesis and biological evaluation of quinazolines as potent inhibitors of multiple intracellular targets, including mic
Autor:
Lisa Polin, Khushbu Shah, Zhanjun Hou, Arpit Doshi, Josephine Frühauf, Md. Junayed Nayeen, Kathryn White, Gregory S. Ducker, Jade M. Katinas, Seongho Kim, Larry H. Matherly, Changwen Ning, Adrianne Wallace-Povirk, Jing Li, Juiwanna Kushner, Maik Hüttemann, Jennifer Wong-Roushar, Carrie O'Connor, Jenney Liu, Xun Bao, Charles E. Dann, Sijana H. Dzinic, Aleem Gangjee, Joshua D. Rabinowitz, Aamod Dekhne
Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria and cytosol and supports cell growth through nucleotide and amino acid biosynthesis. Mitochondrial C1 metabolism, including serine hydroxymethyltransferase (SHMT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae91497edf2a8770b4c5f8bc543f115
https://europepmc.org/articles/PMC6774887/
https://europepmc.org/articles/PMC6774887/
Autor:
D. M. Tripathi, Arpit Doshi
Publikováno v:
The Indian Journal of Pediatrics. 83:386-390
To identify house dust mite (HDM) sensitivity by skin prick test in children with allergic rhinitis, allergic wheezing and eczema. In this prospective study, children with persistent or recurrent allergic symptoms of rhinitis, wheezing and eczema wer
Autor:
Zhanjun Hou, Arpit Doshi, Larry Matherly, Aleem Gangjee, Adrianne Wallace-Povirk, Carrie O'Connor
Publikováno v:
Cancer Research. 80:511-511
One-carbon (1C) metabolism, in tumor cells, provides basic metabolites needed for proliferation and is compartmentalized into the cytosol and mitochondria. The key enzymes in 1C metabolism are de novo purine biosynthesis catalyzing enzymes, glycinami