Výsledky vyhledávání - "Arpine Davtyan"

Prenatal Diagnosis Rate of Critical Congenital Heart Disease Remains Inadequate with Significant Racial/Ethnic and Socioeconomic Disparities and Technical Barriers

Autor: Arpine Davtyan, Heidi Ostler, Ian Fraser Golding, Heather Y. Sun

Background:Prenatal diagnosis (preDx) of critical congenital heart disease (CCHD) decreases neonatal morbidity and mortality. Obstetrical fetal cardiac imaging guidelines in 2013 aimed to increase preDx. Objective: To determine the contemporary preDx

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf30eb3fd33dd65ecdf83a1ce8928add
https://doi.org/10.21203/rs.3.rs-2843670/v1

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Expanded Use of the One-Step Technique for Simultaneous Landing Zone Stenting and Placement of the Melody Transcatheter Pulmonary Valve

Autor: Peter W, Guyon, Bassel, Mohammad Nijres, Henri, Justino, Arpine, Davtyan, Bryan, Mosher, Asimina, Courelli, Kanishka, Ratnayaka, John W, Moore, Howaida G, El-Said

Publikováno v: The Journal of invasive cardiology. 33(12)

We report a multicenter experience with simultaneous right ventricular outflow tract (RVOT) stenting and transcatheter pulmonary valve implantation using the Melody valve (Medtronic).Prestenting the RVOT before Melody valve implantation is now the st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d6e6b72bd81678851e06bf78ed30b4c
https://pubmed.ncbi.nlm.nih.gov/35235531

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Selective Valve Removal for Melody Valve Endocarditis: Practice Variations in a Multicenter Experience

Autor: Arpine Davtyan, Peter W. Guyon, Hannah R. El-Sabrout, Reid Ponder, Nanda Ramchandar, Rachel Weber, Wagih Zayed, Kanishka Ratnayaka, John J. Nigro, John W. Moore, Holly Bauser-Heaton, Laith Alshawabkeh, Ryan R. Reeves, Daniel Levi, Jamil Aboulhosn, Henri Justino, John Bradley, Howaida G. El-Said

Publikováno v: Pediatric cardiology, vol 43, iss 4

Guidelines for management of Melody transcatheter pulmonary valve (TPV) infective endocarditis (IE) are lacking. We aimed to identify factors associated with surgical valve removal versus antimicrobial therapy in Melody TPV IE. Multicenter retrospect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e401a15c0d80a091135950adc2a25c3
https://pubmed.ncbi.nlm.nih.gov/34894280

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Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer’s Disease

Autor: Arpine Davtyan, Michael G. Agadjanyan, Anahit Ghochikyan, Giselle F. Passos, Hayk Davtyan, David H. Cribbs, Irina Petrushina, Armine Hovakimyan

Publikováno v: Molecular Therapy. 25:153-164

Previously, we reported that Alzheimer's disease (AD) epitope vaccines (EVs) composed of N-terminal β-amyloid (Aβ 42 ) B cell epitope fused with universal foreign T helper (Th) epitope(s) were immunogenic, potent, and safe in different amyloid prec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725b4ff1592057b2f131765f0b82636b
https://doi.org/10.1016/j.ymthe.2016.10.002

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A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory

Autor: Arpine Davtyan, Randy A. Albrecht, Annette M. Marleau, Adolfo García-Sastre, Anahit Ghochikyan, Michael G. Agadjanyan, Hayk Davtyan, Richard Cadagan, Armine Hovakimyan

Publikováno v: Journal of Neuroimmunology. 277:77-84

Novel dual vaccine, WSN-Aβ 1–10 , based on the recombinant influenza virus, expressing immunodominant B-cell epitope of β-amyloid, simultaneously induced therapeutically potent anti-Aβ and anti-influenza antibodies. In this study we showed that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448772c7f290652b25aa9247e8ece21d
https://doi.org/10.1016/j.jneuroim.2014.10.002

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BTX AgilePulseTM System is an Effective Electroporation Device for Intramuscular and Intradermal Delivery of DNA Vaccine

Autor: Irina Petrushina, Vidya Murthy, David Agdashian, David H. Cribbs, Karen Zagorski, Hayk Davtyan, Michael G. Agadjanyan, Armine Hovakimyan, Anahit Ghochikyan, Arpine Davtyan

Publikováno v: Current Gene Therapy. 14:190-199

DNA vaccines promote immune system activation in small animals and exhibit certain advantages when compared to conventional recombinant protein vaccines. However in clinical trials DNA vaccines are less effective in inducing potent immune responses d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3711b077bba86f1da422a47e2e8cf41
https://doi.org/10.2174/1566523214666140522121427

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The MultiTEP platform–based Alzheimer's disease epitope vaccine activates a broad repertoire of T helper cells in nonhuman primates

Autor: Arpine Davtyan, Hayk Davtyan, Irina Petrushina, Armine Hovakimyan, Michael G. Agadjanyan, David H. Cribbs, Anahit Ghochikyan

Publikováno v: Alzheimer's & Dementia. 10:271-283

Background As a prelude to clinical trials we have characterized B- and T-cell immune responses in macaques to AD vaccine candidates: AV-1955 and its slightly modified version, AV-1959 (with 3 additional promiscuous Th epitopes). Methods T- and B-cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3aca5807a817610c1df80d904f7e504
https://doi.org/10.1016/j.jalz.2013.12.003

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Immunogenicity of epitope vaccines targeting different B cell antigenic determinants of human α-synuclein: Feasibility study

Autor: Anahit Ghochikyan, Michael G. Agadjanyan, Hayk Davtyan, Irina Petrushina, Arpine Davtyan, Tommy Saing, David H. Cribbs, Armine Hovakimyan

Publikováno v: Neuroscience Letters. 560:86-91

Immunotherapeutic approaches reducing α-synuclein deposits may provide therapeutic benefit for Dementia with Lewy Bodies (DLB). Immunization with full-length human α-synuclein (hα-Syn) protein in a Parkinson's disease mouse model decreased the acc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b0d87ed0f73a6fea0714719fa13dc5
https://doi.org/10.1016/j.neulet.2013.12.028

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Epitope‐based DNA vaccine for Alzheimer's disease: Translational study in macaques

Autor: Claire F. Evans, Arpine Davtyan, Michael G. Agadjanyan, Armine Hovakimyan, Irina Petrushina, David H. Cribbs, Hayk Davtyan, Drew Hannaman, Anahit Ghochikyan

Publikováno v: Alzheimer's & Dementia. 10:284-295

Background Clinical trials with passive and active Alzheimer's disease (AD) vaccines suggest that early interventions are needed for improvement of cognitive and/or functional performance in patients, providing impetus for the development of safe and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90e7b8bbd0e2e7051bc4970da7af1e6
https://doi.org/10.1016/j.jalz.2013.04.505

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