The effects of flavonoids, green tea polyphenols and coffee on DMBA induced LINE-1 DNA hypomethylation.

Autor: Laszlo Szabo, Richard Molnar, Andras Tomesz, Arpad Deutsch, Richard Darago, Ghodratollah Nowrasteh, Timea Varjas, Balazs Nemeth, Ferenc Budan, Istvan Kiss

Publikováno v: PLoS ONE, Vol 16, Iss 4, p e0250157 (2021)

The intake of carcinogenic and chemopreventive compounds are important nutritional factors related to the development of malignant tumorous diseases. Repetitive long interspersed element-1 (LINE-1) DNA methylation pattern plays a key role in both car

Externí odkaz: https://doaj.org/article/4e6ebec2fef64375a733b09be7820dab

Changes in miR-124-1, miR-212, miR-132, miR-134, and miR-155 Expression Patterns after 7,12-Dimethylbenz(a)anthracene Treatment in CBA/Ca Mice

Autor: Andras Tomesz, Laszlo Szabo, Richard Molnar, Arpad Deutsch, Richard Darago, Bence L. Raposa, Nowrasteh Ghodratollah, Timea Varjas, Balazs Nemeth, Zsuzsanna Orsos, Eva Pozsgai, Jozsef L. Szentpeteri, Ferenc Budan, Istvan Kiss

Publikováno v: Cells, Vol 11, Iss 6, p 1020 (2022)

Specific gene and miRNA expression patterns are potential early biomarkers of harmful environmental carcinogen exposures. The aim of our research was to develop an assay panel by using several miRNAs for the rapid screening of potential carcinogens.

Externí odkaz: https://doaj.org/article/07cf8d55ac8a461ea3b6367d1fe53064

Effect of 7,12-Dimethylbenz(α)anthracene on the Expression of miR-330, miR-29a, miR-9-1, miR-9-3 and the mTORC1 Gene in CBA/Ca Mice

Autor: Richard Molnar, Domokos Máthé, Ferenc Budán, Laszlo Szabo, Andras Tomesz, István Kiss, Richard Darago, Tímea Varjas, Balázs Németh, Arpad Deutsch, Nowrasteh Ghodratollah

Publikováno v: In Vivo

Background/aim Development of malignant tumors is preceded by molecular biological events. Our aim was to establish an assay panel by using miRNAs and other genes for the rapid screening of potential carcinogens or chemopreventive agents. Materials a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cbf2117fadfb6a380b818341086c69
https://pubmed.ncbi.nlm.nih.gov/32871758

The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers.

Autor: Molnar, Richard^1,2 (AUTHOR) laszlo.szabo.pte@gmail.com, Szabo, Laszlo^1,2 (AUTHOR) andras.tomesz.pte@gmail.com, Tomesz, Andras^1,2 (AUTHOR) deutscharpad@gmail.com, Deutsch, Arpad¹ (AUTHOR) daragorichard@gmail.com, Darago, Richard¹ (AUTHOR) raposa.bence@gmail.com, Raposa, Bence L.¹ (AUTHOR), Ghodratollah, Nowrasteh² (AUTHOR) zsuzsa.orsos@aok.pte.hu, Varjas, Timea² (AUTHOR) pozsgay83@gmail.com, Nemeth, Balazs² (AUTHOR) istvan.kiss@aok.pte.hu, Orsos, Zsuzsanna² (AUTHOR), Pozsgai, Eva² (AUTHOR), Szentpeteri, Jozsef L.³ (AUTHOR) richard.molnar.pte@gmail.com, Budan, Ferenc^3,4 (AUTHOR) richard.molnar.pte@gmail.com, Kiss, Istvan² (AUTHOR)

Publikováno v: Cells (2073-4409). Apr2022, Vol. 11 Issue 8, p1300. 18p.

Olive Oil Improves While Trans Fatty Acids Further Aggravate the Hypomethylation of LINE-1 Retrotransposon DNA in an Environmental Carcinogen Model

Autor: Laszlo Szabo, Richard Molnar, Andras Tomesz, Arpad Deutsch, Richard Darago, Timea Varjas, Zsombor Ritter, Jozsef L. Szentpeteri, Kitti Andreidesz, Domokos Mathe, Imre Hegedüs, Attila Sik, Ferenc Budan, Istvan Kiss

Publikováno v: Nutrients; Volume 14; Issue 4; Pages: 908
Nutrients

DNA methylation is an epigenetic mechanism that is crucial for mammalian development and genomic stability. Aberrant DNA methylation changes have been detected not only in malignant tumor tissues; the decrease of global DNA methylation levels is also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedc4e40df4566e7a71b5a43219887f6