Nigral ATP13A2 depletion induces Parkinson's disease-related neurodegeneration in a pilot study in non-human primates.

Autor: Sikora J; Univ. Bordeaux, CNRS, IMN, Bordeaux, France.; Univ. De Poitiers, INSERM, LNEC, Poitiers, France., Dovero S; Univ. Bordeaux, CNRS, IMN, Bordeaux, France., Kinet R; Univ. Bordeaux, CNRS, IMN, Bordeaux, France., Arotcarena ML; Univ. Bordeaux, CNRS, IMN, Bordeaux, France., Bohic S; Univ. Grenoble Alpes, Synchrotron Radiation for Biomedicine (STROBE), Grenoble, France., Bezard E; Univ. Bordeaux, CNRS, IMN, Bordeaux, France., Fernagut PO; Univ. De Poitiers, INSERM, LNEC, Poitiers, France., Dehay B; Univ. Bordeaux, CNRS, IMN, Bordeaux, France. benjamin.dehay@u-bordeaux.fr.

Publikováno v: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2024 Aug 01; Vol. 10 (1), pp. 141. Date of Electronic Publication: 2024 Aug 01.

Modeling Parkinson's Disease in Primates.

Autor: Bezard E; Université de Bordeaux, Centre National de la Recherche Scientifique (CNRS), IMN, UMR 5293, F-33000 Bordeaux, France erwan.bezard@u-bordeaux.fr.; Motac Neuroscience, F-33270 Floirac, France.; Motac Beijing Services, PRC-100050 Beijing, China., Teil M; Université de Bordeaux, Centre National de la Recherche Scientifique (CNRS), IMN, UMR 5293, F-33000 Bordeaux, France., Arotcarena ML; Université de Bordeaux, Centre National de la Recherche Scientifique (CNRS), IMN, UMR 5293, F-33000 Bordeaux, France., Porras G; Motac Neuroscience, F-33270 Floirac, France., Li Q; Motac Beijing Services, PRC-100050 Beijing, China., Dehay B; Université de Bordeaux, Centre National de la Recherche Scientifique (CNRS), IMN, UMR 5293, F-33000 Bordeaux, France.

Publikováno v: Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2024 Jul 15. Date of Electronic Publication: 2024 Jul 15.

Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain.

Autor: Teil M; Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France., Dovero S; Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France., Bourdenx M; Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France.; UK Dementia Research Institute, University College London, London, WC1E 6BT, UK., Arotcarena ML; Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France., Darricau M; Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France., Porras G; Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France., Thiolat ML; Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France., Trigo-Damas I; HM CINAC, HM Puerta del Sur, Fundación HM Hospitales and CIBERNED and CEU-San Pablo University Madrid, E-28938, Mostoles, Spain.; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain., Perier C; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain.; Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain., Estrada C; Clinical and Experimental Neuroscience Unit, School of Medicine, Biomedical Research Institute of Murcia (IMIB), University of Murcia, Campus Mare Nostrum, 30100, Murcia, Spain.; Institute of Research on Aging (IUIE), School of Medicine, University of Murcia, 30100, Murcia, Spain., Garcia-Carrillo N; Centro Experimental en Investigaciones Biomédica (CEIB), Universidad de Murcia, Murcia, Spain., Herrero MT; Clinical and Experimental Neuroscience Unit, School of Medicine, Biomedical Research Institute of Murcia (IMIB), University of Murcia, Campus Mare Nostrum, 30100, Murcia, Spain.; Institute of Research on Aging (IUIE), School of Medicine, University of Murcia, 30100, Murcia, Spain., Vila M; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain.; Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.; Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona (UAB), Barcelona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Obeso JA; HM CINAC, HM Puerta del Sur, Fundación HM Hospitales and CIBERNED and CEU-San Pablo University Madrid, E-28938, Mostoles, Spain.; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; CEU, San Pablo University Madrid, E-28938 Mostoles, Spain 2 HM CINAC, HM Puerta del Sur and CIBERNED and CEU-San Pablo University Madrid, E-, 28938, Mostoles, Spain., Bezard E; Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France., Dehay B; Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France. benjamin.dehay@u-bordeaux.fr.

Publikováno v: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2023 Sep 19; Vol. 9 (1), pp. 135. Date of Electronic Publication: 2023 Sep 19.

Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology.

Autor: Teil M; Université de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France., Dovero S; Université de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France., Bourdenx M; Université de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France., Arotcarena ML; Université de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France., Camus S; Université de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France., Porras G; Université de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France., Thiolat ML; Université de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France., Trigo-Damas I; HM CINAC, HM Puerta del Sur and CIBERNED and CEU-San Pablo University Madrid, E-28938 Mostoles, Spain.; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain.; CEU, San Pablo University Madrid, E-28938 Mostoles, Spain., Perier C; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain.; Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR)-Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain., Estrada C; Clinical and Experimental Neuroscience Unit, School of Medicine, Biomedical Research Institute of Murcia (IMIB), University of Murcia, Campus Mare Nostrum, 30100 Murcia, Spain.; Institute of Research on Aging (IUIE), School of Medicine, University of Murcia, 30100 Murcia, Spain., Garcia-Carrillo N; Centro Experimental en Investigaciones Biomédica (CEIB), Universidad de Murcia, Murcia, Spain., Morari M; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, Italy., Meissner WG; Université de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France.; Service de Neurologie-Maladies Neurodégénératives, CRMR Atrophie Multisystématisée, CHU Bordeaux, F-33000 Bordeaux, France., Herrero MT; Clinical and Experimental Neuroscience Unit, School of Medicine, Biomedical Research Institute of Murcia (IMIB), University of Murcia, Campus Mare Nostrum, 30100 Murcia, Spain.; Institute of Research on Aging (IUIE), School of Medicine, University of Murcia, 30100 Murcia, Spain., Vila M; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain.; Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR)-Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.; Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona (UAB), Barcelona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain., Obeso JA; HM CINAC, HM Puerta del Sur and CIBERNED and CEU-San Pablo University Madrid, E-28938 Mostoles, Spain.; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain.; CEU, San Pablo University Madrid, E-28938 Mostoles, Spain., Bezard E; Université de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France., Dehay B; Université de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France.

Publikováno v: Brain : a journal of neurology [Brain] 2022 Apr 29; Vol. 145 (3), pp. 1001-1017.

Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques.

Autor: Arotcarena ML; CNRS, IMN, UMR 5293, Univ. Bordeaux, Bordeaux, France., Dovero S; CNRS, IMN, UMR 5293, Univ. Bordeaux, Bordeaux, France., Biendon N; CNRS, IMN, UMR 5293, Univ. Bordeaux, Bordeaux, France., Dutheil N; CNRS, IMN, UMR 5293, Univ. Bordeaux, Bordeaux, France., Planche V; CNRS, IMN, UMR 5293, Univ. Bordeaux, Bordeaux, France.; Centre Memoire de Ressources et de Recherches, Pôle de Neurosciences Cliniques, CHU de Bordeaux, Bordeaux, France., Bezard E; CNRS, IMN, UMR 5293, Univ. Bordeaux, Bordeaux, France., Dehay B; CNRS, IMN, UMR 5293, Univ. Bordeaux, Bordeaux, France.

Publikováno v: Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2021 Nov 15; Vol. 9, pp. 762209. Date of Electronic Publication: 2021 Nov 15 (Print Publication: 2021).