Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes.

Autor: Martin-Rufino JD; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA.; Equally contributed to work., Caulier A; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA.; Equally contributed to work., Lee S; Broad Institute of MIT and Harvard, Boston, MA, USA.; Equally contributed to work., Castano N; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA.; Equally contributed to work., King E; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA., Joubran S; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA., Jones M; Nascent Transcriptomics Core, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Goldman SR; Nascent Transcriptomics Core, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Arora UP; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA., Wahlster L; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA., Lander ES; Broad Institute of MIT and Harvard, Boston, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 09. Date of Electronic Publication: 2024 Sep 09.

Inherited blood cancer predisposition through altered transcription elongation.

Autor: Zhao J; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Cancer Immunology, Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen, China. Electronic address: jw.zhao3@siat.ac.cn., Cato LD; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Arora UP; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bao EL; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bryant SC; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Williams N; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK; UK and MRC-Wellcome Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Jia Y; Harvard Stem Cell Institute, Cambridge, MA, USA; Stem Cell Program, Boston Children's Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Goldman SR; Nascent Transcriptomics Core, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Nangalia J; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK; UK and MRC-Wellcome Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Erb MA; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Vos SM; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Armstrong SA; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA. Electronic address: sankaran@broadinstitute.org.

Publikováno v: Cell [Cell] 2024 Feb 01; Vol. 187 (3), pp. 642-658.e19. Date of Electronic Publication: 2024 Jan 12.

Variation in the CENP-A sequence association landscape across diverse inbred mouse strains.

Autor: Arora UP; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA; Graduate School of Biomedical Sciences, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA. Electronic address: uma.arora@jax.org., Sullivan BA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, 213 Research Drive, Box 3054, Durham, NC 27710, USA., Dumont BL; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA; Graduate School of Biomedical Sciences, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA; Graduate School of Biomedical Science and Engineering, University of Maine, 5775 Stodder Hall, Room 46, Orono, ME 04469, USA. Electronic address: beth.dumont@jax.org.

Publikováno v: Cell reports [Cell Rep] 2023 Oct 31; Vol. 42 (10), pp. 113178. Date of Electronic Publication: 2023 Sep 23.

Selection shapes the landscape of functional variation in wild house mice.

Autor: Lawal RA; The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609, USA. lawalakinyanju@yahoo.com., Arora UP; The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609, USA.; Tufts University, Graduate School of Biomedical Sciences, 136 Harrison Ave, Boston, MA, 02111, USA., Dumont BL; The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609, USA. beth.dumont@jax.org.; Tufts University, Graduate School of Biomedical Sciences, 136 Harrison Ave, Boston, MA, 02111, USA. beth.dumont@jax.org.

Publikováno v: BMC biology [BMC Biol] 2021 Nov 19; Vol. 19 (1), pp. 239. Date of Electronic Publication: 2021 Nov 19.

Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models.

Autor: Dumont, Beth L.^1,2,3 (AUTHOR) beth.dumont@jax.org, Gatti, Daniel M.¹ (AUTHOR), Ballinger, Mallory A.⁴ (AUTHOR), Lin, Dana⁵ (AUTHOR), Phifer-Rixey, Megan⁶ (AUTHOR), Sheehan, Michael J.⁷ (AUTHOR), Suzuki, Taichi A.⁸ (AUTHOR), Wooldridge, Lydia K.¹ (AUTHOR), Frempong, Hilda Opoku^1,3 (AUTHOR), Lawal, Raman Akinyanju¹ (AUTHOR), Churchill, Gary A.^1,2,3 (AUTHOR), Lutz, Cathleen¹ (AUTHOR), Rosenthal, Nadia^1,2,3,9 (AUTHOR), White, Jacqueline K.¹ (AUTHOR), Nachman, Michael W.¹⁰ (AUTHOR) beth.dumont@jax.org

Publikováno v: PLoS Genetics. 4/10/2024, Vol. 20 Issue 4, p1-41. 41p.