Zobrazeno 1 - 10
of 429
pro vyhledávání: '"Aroon D. Hingorani"'
Autor:
María Gordillo-Marañón, Amand F. Schmidt, Alasdair Warwick, Chris Tomlinson, Cai Ytsma, Jorgen Engmann, Ana Torralbo, Rory Maclean, Reecha Sofat, Claudia Langenberg, Anoop D. Shah, Spiros Denaxas, Munir Pirmohamed, Harry Hemingway, Aroon D. Hingorani, Chris Finan
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-11 (2024)
Abstract Background Despite the growing interest in the use of human genomic data for drug target identification and validation, the extent to which the spectrum of human disease has been addressed by genome-wide association studies (GWAS), or by dru
Externí odkaz:
https://doaj.org/article/14ac4ccb0e8349ce89515b8fe565b434
Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study
Autor:
Diana Dunca, Sandesh Chopade, María Gordillo-Marañón, Aroon D. Hingorani, Karoline Kuchenbaecker, Chris Finan, Amand F. Schmidt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract CETP inhibitors are a class of lipid-lowering drugs in development for treatment of coronary heart disease (CHD). Genetic studies in East Asian ancestry have interpreted the lack of CETP signal with low-density lipoprotein cholesterol (LDL-C
Externí odkaz:
https://doaj.org/article/23e5af9de5984d279421ac7ebb2dc74e
Autor:
Constantin-Cristian Topriceanu, Mit Shah, Matthew Webber, Fiona Chan, Hunain Shiwani, Marcus Richards, Jonathan Schott, Nishi Chaturvedi, James C. Moon, Alun D. Hughes, Aroon D. Hingorani, Declan P. O’Regan, Gabriella Captur
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Although APOE ε4 allele carriage confers a risk for coronary artery disease, its persistence in humans might be explained by certain survival advantages (antagonistic pleiotropy). Methods Combining data from ~ 37,000 persons from
Externí odkaz:
https://doaj.org/article/11cdd86813114bbcb62a5c1ef1c08698
Autor:
A. Floriaan Schmidt, Chris Finan, Sandesh Chopade, Stephan Ellmerich, Martin N. Rossor, Aroon D. Hingorani, Mark B. Pepys
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
The mechanisms responsible for neuronal death causing cognitive loss in Alzheimer's disease (AD) and many other dementias are not known. Serum amyloid P component (SAP) is a constitutive plasma protein, which is cytotoxic for cerebral neurones and al
Externí odkaz:
https://doaj.org/article/7b7fa5020a354c8684a1fb1ebee1aca7
Autor:
Amand F. Schmidt, Roshni Joshi, Maria Gordillo-Marañón, Fotios Drenos, Pimphen Charoen, Claudia Giambartolomei, Joshua C. Bis, Tom R. Gaunt, Alun D. Hughes, Deborah A. Lawlor, Andrew Wong, Jackie F. Price, Nishi Chaturvedi, Goya Wannamethee, Nora Franceschini, Mika Kivimaki, Aroon D. Hingorani, Chris Finan
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-10 (2023)
Schmidt et al. evaluate the effects of elevated circulating concentrations of cholesterol-containing lipoproteins and apolipoproteins. Effects are seen on measures of atherosclerosis, blood pressure, c-reactive protein, coronary heart disease, heart
Externí odkaz:
https://doaj.org/article/a4840a392ca142fd8b56739e6ab3255e
Autor:
Maria Carolina Borges, Philip C. Haycock, Jie Zheng, Gibran Hemani, Michael V. Holmes, George Davey Smith, Aroon D. Hingorani, Deborah A. Lawlor
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Despite early interest in the health effects of polyunsaturated fatty acids (PUFA), there is still substantial controversy and uncertainty on the evidence linking PUFA to cardiovascular diseases (CVDs). We investigated the effect
Externí odkaz:
https://doaj.org/article/10166105780f40739bdb8fb2a77ec801
Autor:
Riyaz S. Patel, Laura Pasea, Handrean Soran, Paul Downie, Richard Jones, Aroon D. Hingorani, Dermot Neely, Spiros Denaxas, Harry Hemingway
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-12 (2022)
Abstract Background Assessing the spectrum of disease risk associated with hypertriglyceridemia is needed to inform potential benefits from emerging triglyceride lowering treatments. We sought to examine the associations between a full range of plasm
Externí odkaz:
https://doaj.org/article/98d3cfc3aa7a4b1ba2955d4b65cc4d3d
Autor:
Catherine S. Storm, Demis A. Kia, Mona M. Almramhi, Sara Bandres-Ciga, Chris Finan, International Parkinson’s Disease Genomics Consortium (IPDGC), Aroon D. Hingorani, Nicholas W. Wood
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
There is currently no disease-modifying treatment for Parkinson’s disease, a common neurodegenerative disorder. Here, the authors use genetic variation associated with gene and protein expression to find putative drug targets for Parkinson’s dise
Externí odkaz:
https://doaj.org/article/12208590cd7c49fd96e1688f45f4bf65
Autor:
R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans‐Peter Brunner‐La Rocca, David J. Carey, Mark D. Chaffin, Daniel I. Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H. Chung, William Chutkow, John G.F. Cleland, James P. Cook, Simon deDenus, Abbas Dehghan, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Dörr, Samuel C. Dudley, Gunnar Engström, Tõnu Esko, Ghazaleh Fatemifar, Stephan B. Felix, Chris Finan, Ian Ford, Francoise Fougerousse, René Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daníel F. Guðbjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M. Haggerty, Pim van derHarst, Åsa K. Hedman, Anna Helgadottir, Hans Hillege, Craig L. Hyde, Jaison Jacob, J. Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay‐Tee Khaw, Marcus E. Kleber, Lars Køber, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B. Margulies, Nicholas A. Marston, Winfried März, John J.V. McMurray, Olle Melander, Giorgio Melloni, Ify R. Mordi, Michael P. Morley, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Christopher Newton‐Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L. O'Donoghue, Anjali T. Owens, Colin N.A. Palmer, Guillaume Paré, Markus Perola, Louis‐Philippe Lemieux Perreault, Eliana Portilla‐Fernandez, Bruce M. Psaty, Kenneth M. Rice, Paul M. Ridker, Simon P.R. Romaine, Carolina Roselli, Jerome I. Rotter, Christian T. Ruff, Marc S. Sabatine, Perttu Salo, Veikko Salomaa, Jessica vanSetten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Kari Stefansson, Steen Stender, David J. Stott, Garðar Sveinbjörnsson, Mari‐Liis Tammesoo, Jean‐Claude Tardif, Kent D. Taylor, Maris Teder‐Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp‐Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G. Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M. Visscher, Uwe Völker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Peter E. Weeke, Raul Weiss, Harvey D. White, Kerri L. Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M. Yerges‐Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Regeneron Genetics Center, Jemma B. Wilk, Hilma Holm, Naveed Sattar, Steven A. Lubitz, David E. Lanfear, Svati Shah, Michael E. Dunn, Quinn S. Wells, Folkert W. Asselbergs, Aroon D. Hingorani, Marie‐Pierre Dubé, Nilesh J. Samani, Chim C. Lang, Thomas P. Cappola, Patrick T. Ellinor, Ramachandran S. Vasan, J. Gustav Smith
Publikováno v:
ESC Heart Failure, Vol 8, Iss 6, Pp 5531-5541 (2021)
Abstract Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results The consortium currently includes 51 studies from 11 countries,
Externí odkaz:
https://doaj.org/article/77600c13420346d3a1c4c66140b2a3c7
Autor:
Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, Nicola D. Kerrison, Erin Oerton, Mine Koprulu, Jian’an Luan, Aroon D. Hingorani, Steve A. Williams, Nicholas J. Wareham, Claudia Langenberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Broad-capture affinity-based proteomic technologies inform how the readout of our genes affects human health. Here, the authors integrate aptamer- and antibody-based profiling to understand the mechanisms underlying gene-protein-disease associations.
Externí odkaz:
https://doaj.org/article/ae9a1bfa769147d886496493f0292435