Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Aron H. Lichtman"'
Autor:
Alexis F. League, Barkha J. Yadav-Samudrala, Ramya Kolagani, Calista A. Cline, Ian R. Jacobs, Jonathan Manke, Micah J. Niphakis, Benjamin F. Cravatt, Aron H. Lichtman, Bogna M. Ignatowska-Jankowska, Sylvia Fitting
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundHuman immunodeficiency virus (HIV) affects nearly 40 million people globally, with roughly 80% of all people living with HIV receiving antiretroviral therapy. Antiretroviral treatment suppresses viral load in peripheral tissues but does not
Externí odkaz:
https://doaj.org/article/8c79ef5970b94294a9b7f4e26a0627ff
Autor:
Barkha J. Yadav-Samudrala, Hailey Dodson, Shreya Ramineni, Elizabeth Kim, Justin L. Poklis, Dai Lu, Bogna M. Ignatowska-Jankowska, Aron H. Lichtman, Sylvia Fitting
Publikováno v:
PLoS ONE, Vol 19, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/eb66f6a202fc471996a06aacd52c2124
Autor:
Douglas J. Hermes, Ian R. Jacobs, Megan C. Key, Alexis F. League, Barkha J. Yadav-Samudrala, Changqing Xu, Virginia D. McLane, Sara R. Nass, Wei Jiang, Rick B. Meeker, Bogna M. Ignatowska-Jankowska, Aron H. Lichtman, Zibo Li, Zhanhong Wu, Hong Yuan, Pamela E. Knapp, Kurt F. Hauser, Sylvia Fitting
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-26 (2020)
Abstract Background Human immunodeficiency virus type-1 (HIV-1) and opiates cause long-term inflammatory insult to the central nervous system (CNS) and worsen disease progression and HIV-1-related neuropathology. The combination of these proinflammat
Externí odkaz:
https://doaj.org/article/9e4741df53be4e07958134c87b308da3
Autor:
Alexis F. League, Benjamin L. Gorman, Douglas J. Hermes, Clare T. Johnson, Ian R. Jacobs, Barkha J. Yadav-Samudrala, Justin L. Poklis, Micah J. Niphakis, Benjamin F. Cravatt, Aron H. Lichtman, Bogna M. Ignatowska-Jankowska, Sylvia Fitting
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
While current therapeutic strategies for people living with human immunodeficiency virus type 1 (HIV-1) suppress virus replication peripherally, viral proteins such as transactivator of transcription (Tat) enter the central nervous system early upon
Externí odkaz:
https://doaj.org/article/96308e6b0d6242b6a0b4435ff529f372
Autor:
Erin M. Rock, Cheryl L. Limebeer, Megan T. Sullivan, Marieka V. DeVuono, Aron H. Lichtman, Vincenzo Di Marzo, Raphael Mechoulam, Linda A. Parker
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
The endogenous amide N-Oleoylglycine (OlGly) and its analog N-Oleoylalanine (OlAla), have been shown to interfere with the affective and somatic responses to acute naloxone-precipitated MWD in male rats. Here we evaluated the potential of a single do
Externí odkaz:
https://doaj.org/article/518b6faff5a9422b904f217ce7e61067
Autor:
Changqing Xu, Barkha J. Yadav-Samudrala, Callie Xu, Bhupendra Nath, Twisha Mistry, Wei Jiang, Micah J. Niphakis, Benjamin F. Cravatt, Somnath Mukhopadhyay, Aron H. Lichtman, Bogna M. Ignatowska-Jankowska, Sylvia Fitting
Publikováno v:
Cells, Vol 11, Iss 5, p 857 (2022)
(1) Background. The endocannabinoid (eCB) system, which regulates physiological and cognitive processes, presents a promising therapeutic target for treating HIV-associated neurocognitive disorders (HAND). Here we examine whether upregulating eCB ton
Externí odkaz:
https://doaj.org/article/7bfb5fc1636b4b7ebe5e207c9bcd5f92
Autor:
Marjolein Soethoudt, Uwe Grether, Jürgen Fingerle, Travis W. Grim, Filomena Fezza, Luciano de Petrocellis, Christoph Ullmer, Benno Rothenhäusler, Camille Perret, Noortje van Gils, David Finlay, Christa MacDonald, Andrea Chicca, Marianela Dalghi Gens, Jordyn Stuart, Henk de Vries, Nicolina Mastrangelo, Lizi Xia, Georgios Alachouzos, Marc P. Baggelaar, Andrea Martella, Elliot D. Mock, Hui Deng, Laura H. Heitman, Mark Connor, Vincenzo Di Marzo, Jürg Gertsch, Aron H. Lichtman, Mauro Maccarrone, Pal Pacher, Michelle Glass, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
CB2 receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB2 receptor agonists and antagonists, recommending three that appear most suitab
Externí odkaz:
https://doaj.org/article/d8fb448abc4444e3a10089f8b36e11e6
Autor:
Yun K. Hahn, Jason J. Paris, Aron H. Lichtman, Kurt F. Hauser, Laura J. Sim-Selley, Dana E. Selley, Pamela E. Knapp
Publikováno v:
Neurobiology of Disease, Vol 92, Iss , Pp 124-136 (2016)
Co-exposure to opiates and HIV/HIV proteins results in enhanced CNS morphological and behavioral deficits in HIV+ individuals and in animal models. Opiates with abuse liability, such as heroin and morphine, bind preferentially to and have pharmacolog
Externí odkaz:
https://doaj.org/article/46a94e8e2b4741659b64212514726b3d
Autor:
Andreu Viader, Jacqueline L. Blankman, Peng Zhong, Xiaojie Liu, Joel E. Schlosburg, Christopher M. Joslyn, Qing-Song Liu, Aaron J. Tomarchio, Aron H. Lichtman, Dana E. Selley, Laura J. Sim-Selley, Benjamin F. Cravatt
Publikováno v:
Cell Reports, Vol 12, Iss 5, Pp 798-808 (2015)
The endocannabinoid 2-arachidonoylglycerol (2-AG) is a retrograde lipid messenger that modulates synaptic function, neurophysiology, and behavior. 2-AG signaling is terminated by enzymatic hydrolysis—a reaction that is principally performed by mono
Externí odkaz:
https://doaj.org/article/a58d2651f0fd4eff8581e58600acdec0
Autor:
Billy R. Martin, Aron H. Lichtman
Publikováno v:
Neurobiology of Disease, Vol 5, Iss 6, Pp 447-461 (1998)
The use of cannabis for the management of a wide range of painful disorders has been well documented in case reports throughout history. However, clinical evaluations of cannabis and its psychoactive constituent THC have not led to a consensus regard
Externí odkaz:
https://doaj.org/article/33650ddb4da248acba0c4a1f0c5b3aaf