Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Aron H. Blaesi"'
Publikováno v:
International Journal of Pharmaceutics. :122378
Recently, we have shown in dogs that the gastric residence time of expandable fibrous dosage forms can be prolonged by a strengthening enteric coating on the fibers. In this work, the effect of the volume fraction of the coating, φ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc2a45cdc73d13b6bbba6732aa30586
https://doi.org/10.1016/j.ijpharm.2022.122378
https://doi.org/10.1016/j.ijpharm.2022.122378
Autor:
Aron H. Blaesi, Nannaji Saka
Publikováno v:
International journal of pharmaceutics. 606
In this work, the role of excipient molecular weight in drug release by close-packed, highly drug-loaded fibrous dosage forms is investigated. Three dosage forms with 87 wt% ibuprofen drug, and 13 wt% hydroxypropyl methylcellulose (HPMC) excipient of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7f5e85f9205f86d8cbc755cb2dfcd1
https://pubmed.ncbi.nlm.nih.gov/33246051
https://pubmed.ncbi.nlm.nih.gov/33246051
Autor:
Nannaji Saka, Aron H. Blaesi
Publikováno v:
International Journal of Pharmaceutics. 615:120396
In this work, expandable fibrous dosage forms containing water-absorbing and fiber-strengthening excipients are investigated for prolonged delivery of sparingly-soluble drugs. The formulation comprised: sparingly-soluble ibuprofen drug; water-absorbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf09f2ba3e2f577730e92e5eff0b4305
https://doi.org/10.1016/j.ijpharm.2021.120396
https://doi.org/10.1016/j.ijpharm.2021.120396
Publikováno v:
International Journal of Pharmaceutics. 613:120792
The expandable, gastroretentive dosage forms are promising for precise control of drug concentration in blood. So far, however, short gastric retention times and safety considerations have precluded their use. In this work, to mitigate the above limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09377aa25181f759827af153d3a8a582
https://doi.org/10.1016/j.ijpharm.2021.120792
https://doi.org/10.1016/j.ijpharm.2021.120792
Autor:
Nannaji Saka, Aron H. Blaesi
Publikováno v:
Materials Science and Engineering: C. 80:715-727
In recent studies, we have introduced melt-processed polymeric cellular dosage forms to achieve both immediate drug release and predictable manufacture. Dosage forms ranging from minimally-porous solids to highly porous, open-cell and thin-walled str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95935777749b20ae012f7468fbb871d
https://doi.org/10.1016/j.msec.2017.05.080
https://doi.org/10.1016/j.msec.2017.05.080
Autor:
Nannaji Saka, Aron H. Blaesi
Publikováno v:
Chemical Engineering Journal. 320:549-560
The most prevalent pharmaceutical dosage forms at present are granular solids in the form of oral tablets and capsules. While effective in releasing drug rapidly upon contact with gastrointestinal fluid, their manufacture, which relies on particulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a132d90fd8714bd3ca77d96a154f309d
https://doi.org/10.1016/j.cej.2017.02.057
https://doi.org/10.1016/j.cej.2017.02.057
Autor:
Luca Zazzeron, Daniel Bloch, Lee E. Goldstein, Noel Casey, Rajeev Malhotra, Alexander Morrese, Warren M. Zapol, Danil Dobrynin, Binglan Yu, Aron H. Blaesi, Rosemary Jones, Grigory Raykhtsaum
Publikováno v:
Nitric Oxide. 60:16-23
Inhalation of nitric oxide (NO) produces selective pulmonary vasodilation without dilating the systemic circulation. However, the current NO/N2 cylinder delivery system is cumbersome and expensive. We developed a lightweight, portable, and economical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b92ae72e60793b771fa2e5933712467
https://doi.org/10.1016/j.niox.2016.08.005
https://doi.org/10.1016/j.niox.2016.08.005
Autor:
Nannaji Saka, Aron H. Blaesi
Publikováno v:
International Journal of Pharmaceutics. 509:444-453
At present, the immediate-release solid dosage forms, such as the oral tablets and capsules, are granular solids. They release drug rapidly and have adequate mechanical properties, but their manufacture is fraught with difficulties inherent in proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9d8be86a1363c9e29a49149d397696
https://doi.org/10.1016/j.ijpharm.2016.05.020
https://doi.org/10.1016/j.ijpharm.2016.05.020
Autor:
Aron H. Blaesi, Nannaji Saka
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 103:210-218
The most prevalent pharmaceutical dosage forms at present-the oral immediate-release tablets and capsules-are granular solids. Though effective in releasing drug rapidly, development and manufacture of such dosage forms are fraught with difficulties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35fe72dd995853b8737981cbf62da77
https://doi.org/10.1016/j.ejpb.2016.03.032
https://doi.org/10.1016/j.ejpb.2016.03.032
Autor:
Nannaji Saka, Aron H. Blaesi
Publikováno v:
Materials Science and Engineering: C. 120:110144
Many drug therapies could be greatly improved by dosage forms that reside in the stomach for prolonged time and release the drug slowly. In this work, therefore, slow-release fibrous dosage forms that expand rapidly in the gastric fluid to prevent th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acbf4af9519242519996c0d95d09cfe
https://doi.org/10.1016/j.msec.2019.110144
https://doi.org/10.1016/j.msec.2019.110144