Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Aron D. Thall"'
Autor:
Laura Q.M. Chow, Emmett V. Schmidt, Nuzhat Pathan, Aron D. Thall, Ying Chen, Dhiraj Gambhire, Bo Huang, Donna Di Gravio, Drew W. Rasco, Amita Patnaik, Kyriakos P. Papadopoulos, Siwen Hu-Lieskovan, Mario Sznol, Anthony W. Tolcher
Purpose: This phase Ib study (NCT02179918) evaluated the safety, antitumor activity, pharmacokinetics, and pharmacodynamics of utomilumab, a fully human IgG2 mAb agonist of the T-cell costimulatory receptor 4-1BB/CD137 in combination with the humaniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6766cae734be63dd75a5936338ec69d8
https://doi.org/10.1158/1078-0432.c.6526895
https://doi.org/10.1158/1078-0432.c.6526895
Autor:
Laura Q.M. Chow, Emmett V. Schmidt, Nuzhat Pathan, Aron D. Thall, Ying Chen, Dhiraj Gambhire, Bo Huang, Donna Di Gravio, Drew W. Rasco, Amita Patnaik, Kyriakos P. Papadopoulos, Siwen Hu-Lieskovan, Mario Sznol, Anthony W. Tolcher
Table S1. Patient flow by dose group Table S2. PK parameters of utomilumab following multiple dosing Figure S1. Partial response in a patient with anaplastic thyroid carcinoma (utomilumab 3.6 mg/kg + pembrolizumab 2 mg/kg) at cycle 4 versus baseline.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d00ed2207eedc70c665158d99df5b8
https://doi.org/10.1158/1078-0432.22468295.v1
https://doi.org/10.1158/1078-0432.22468295.v1
Autor:
Ajay K. Gopal, Aron D. Thall, Bo Huang, Craig B. Davis, Ying Chen, Rossano Cesari, Michael J. Pishvaian, Shailender Bhatia, Ronald Levy, Toshihiko Doi, Aiwu R. He, Neil H. Segal
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41a796eb3e053095d935505926b1b1b
https://doi.org/10.1158/1078-0432.22465487
https://doi.org/10.1158/1078-0432.22465487
Autor:
Ajay K. Gopal, Aron D. Thall, Bo Huang, Craig B. Davis, Ying Chen, Rossano Cesari, Michael J. Pishvaian, Shailender Bhatia, Ronald Levy, Toshihiko Doi, Aiwu R. He, Neil H. Segal
Purpose: Utomilumab (PF-05082566) is an agonistic mAb that engages the immune costimulatory molecule 4-1BB/CD137. In this first-in-human, phase I, open-label, multicenter, multiple-dose study (NCT01307267) we evaluated safety, tolerability, pharmacok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694989971a65a86e3429b40415deb7d4
https://doi.org/10.1158/1078-0432.c.6526034.v1
https://doi.org/10.1158/1078-0432.c.6526034.v1
Autor:
Ajay K. Gopal, Aron D. Thall, Bo Huang, Craig B. Davis, Ying Chen, Rossano Cesari, Michael J. Pishvaian, Shailender Bhatia, Ronald Levy, Toshihiko Doi, Aiwu R. He, Neil H. Segal
Supplementary Table S1. Reason for treatment discontinuation Supplementary Table S2. Select laboratory abnormalities by maximum CTCAE grade Supplementary Table S3. Pharmacokinetic parameters for single-agent utomilumab (cycle 1) Supplementary Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08d9dbb5c451b56c61fbcb212dfdf52
https://doi.org/10.1158/1078-0432.22465484
https://doi.org/10.1158/1078-0432.22465484
Autor:
Petr Mály, Aron D. Thall, Thomas Moll, John B. Lowe, Olaf Zöllner, Min-Chuan Huang, Dietmar Vestweber
Publikováno v:
The Journal of biological chemistry. 275(40)
P-selectin glycoprotein ligand-1 (PSGL-1) and E-selectin ligand-1 (ESL-1) are the two major selectin ligands on mouse neutrophils. Transfection experiments demonstrate that each ligand requires alpha1,3-fucosylation for selectin-binding. However, the
Autor:
Aron D. Thall
Publikováno v:
α-Gal and Anti-Gal ISBN: 9781461371601
All mammals, with the exception of apes, Old World monkeys, and humans possess a functional α1,3GT gene (Galili et al., 1990). Microsomal preparations from tissues of mammalian species as divergent as pigs, cows, New World monkey and mice all contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b63e04595df7d0aaf850836793981c67
https://doi.org/10.1007/978-1-4615-4771-6_11
https://doi.org/10.1007/978-1-4615-4771-6_11
Publikováno v:
The Journal of biological chemistry. 270(37)
The Gal alpha 1--3Gal structure is displayed on the zona pellucida glycoprotein ZP3 on murine oocytes. This trisaccharide has been implicated in sperm-zona pellucida adhesive events thought to be essential to fertilization in the mouse. To determine
Autor:
Kevin M. Gersten, Guiying Cheng, Jonathon W. Homeister, Petr Malý, Glennda Smithson, Clare E. Rogers, Rory M. Marks, Aron D. Thall, Ulrich H. von Andrian, Anup Kumar Misra, Peter L. Smith, Bronia Petryniak, John B. Lowe, Sanaz Askari, Robert Kelly, Ole Hindsgaul
Publikováno v:
Immunity. (1):115-126
E-, P-, and L-selectin counterreceptor activities, leukocyte trafficking, and lymphocyte homing are controlled prominently but incompletely by α(1,3)fucosyltransferase FucT-VII-dependent fucosylation. Molecular determinants for FucT-VII-independent