Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Aroli Marcellinus"'
Autor:
Muhammad Adnan Pramudito, Yunendah Nur Fuadah, Ali Ikhsanul Qauli, Aroli Marcellinus, Ki Moo Lim
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-24 (2024)
Abstract The Comprehensive In-vitro Proarrhythmia Assay (CiPA) initiative aims to refine the assessment of drug-induced torsades de pointes (TdP) risk, utilizing computational models to predict cardiac drug toxicity. Despite advancements in machine l
Externí odkaz:
https://doaj.org/article/72eb694cfceb43bab85ca7bb9da9ad16
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Torsades de pointes (TdP) is a type of ventricular arrhythmia that can lead to sudden cardiac death. Drug-induced TdP has been an important concern for researchers and international regulatory boards. The Comprehensive in vitro Proarrhythmia Assay (C
Externí odkaz:
https://doaj.org/article/eaa150b4502046df872733c12ef93397
Autor:
Yunendah Nur Fuadah, Ali Ikhsanul Qauli, Aroli Marcellinus, Muhammad Adnan Pramudito, Ki Moo Lim
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Predicting ventricular arrhythmia Torsade de Pointes (TdP) caused by drug-induced cardiotoxicity is essential in drug development. Several studies used single biomarkers such as qNet and Repolarization Abnormality (RA) in a single cardi
Externí odkaz:
https://doaj.org/article/d9dfbfd90db64896963cec7925a30d82
Autor:
Ali Ikhsanul Qauli, Aroli Marcellinus, Muhammad Aldo Setiawan, Andi Faiz Naufal Zain, Azka Muhammad Pinandito, Ki Moo Lim
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Researchers have recently proposed the Comprehensive In-vitro Proarrhythmia Assay (CiPA) to analyze medicines’ TdP risks. Using the TdP metric known as qNet, numerous single-drug effects have been studied to classify the medications as low
Externí odkaz:
https://doaj.org/article/7fba08efa51c40b8ab2f78b95ae0b6ba
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 5, Pp 653-664 (2022)
Abstract Comprehensive in vitro Proarrhythmia Assay (CiPA) projects for assessing proarrhythmic drugs suggested a logistic regression model using qNet as the Torsades de Pointes (TdP) risk assessment biomarker, obtained from in silico simulation. How
Externí odkaz:
https://doaj.org/article/ba04e93fa30541eb846c183b4b108737
qInward variability-based in-silico proarrhythmic risk assessment of drugs using deep learning model
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Many researchers have suggested evaluation methods and Torsades de Pointes (TdP) metrics to assess the proarrhythmic risk of a drug based on the in silico simulation, as part of the Comprehensive in-vitro Proarrhythmia Assay (CiPA) project. In the pr
Externí odkaz:
https://doaj.org/article/9f6d9f975a2d41539458af30ad9bda57
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Since the Comprehensive in vitro Proarrhythmia Assay (CiPA) initiation, many studies have suggested various in silico features based on ionic charges, action potentials (AP), or intracellular calcium (Ca) to assess proarrhythmic risk. These in silico
Externí odkaz:
https://doaj.org/article/282bfb71b35343de918f03c233e69148
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 406 (2023)
This study proposes a convolutional neural network (CNN) model using action potential (AP) shapes as input for proarrhythmic risk assessment, considering the hypothesis that machine-learning features automatically extracted from AP shapes contain mor
Externí odkaz:
https://doaj.org/article/90a0d8c2f37e4356a1a675eb340a7744
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
As part of the Comprehensive in vitro Proarrhythmia Assay initiative, methodologies for predicting the occurrence of drug-induced torsade de pointes via computer simulations have been developed and verified recently. However, their predictive perform
Externí odkaz:
https://doaj.org/article/14fd1240dca347a5bc941e1d05707fb3
Publikováno v:
Bioengineering, Vol 9, Iss 11, p 628 (2022)
Action potential duration (APD) alternans, an alternating phenomenon between action potentials in cardiomyocytes, causes heart arrhythmia when the heart rate is high. However, some of the APD alternans observed in clinical trials occurs under slow he
Externí odkaz:
https://doaj.org/article/4d93381615834ce5bd15041b0d0717a8