Systemic delivery of siRNA down regulates brain prion protein and ameliorates neuropathology in prion disorder.

Autor: Sylvain Lehmann, Aroa Relano-Gines, Sarah Resina, Elsa Brillaud, Danielle Casanova, Charles Vincent, Claire Hamela, Sophie Poupeau, Mathieu Laffont, Audrey Gabelle, Constance Delaby, Maxime Belondrade, Jacques-Damien Arnaud, Maria-Teresa Alvarez, Jean-Claude Maurel, Patrick Maurel, Carole Crozet

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88797 (2014)

One of the main challenges for neurodegenerative disorders that are principally incurable is the development of new therapeutic strategies, which raises important medical, scientific and societal issues. Creutzfeldt-Jakob diseases are rare neurodegen

Externí odkaz: https://doaj.org/article/52f624261a8149179e79622751bf372e

Photobiomodulation at the level of single neural cells in culture

Autor: Serge Monneret, Ljiljana Durdevic, Julien Savatier, Aroa Relano-Gines, Guillaume Blivet, Guillaume Baffou, Laura Auboyer

Publikováno v: Mechanisms and Techniques in Photodynamic Therapy and Photobiomodulation.

Recently, we introduced a novel treatment of Alzheimer's disease (AD) consisting of the use of photobiomodulation (PBM) coupled with a static magnetic field . The efficiency of this approach was evidenced on a model of mice affected by a neurotoxic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21ad236891e6c7fe676174db28d5277d
https://doi.org/10.1117/12.2578427

Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice

Autor: Carlos Cepeda, Alvin R. King, Joshua Barry, Dane P. Coleal‐Bergum, Jack C. Reidling, Gerhard Bauer, Alice Lau, Andrew H. Tran, Talia Kamdjou, Sandra M. Holley, Sylvia Y. Yeung, Brian Fury, Asa Hatami, Chunni Zhu, Charles K. Meshul, Joseph Ochaba, Delaram Salamati, Mathew Blurton-Jones, Frank M. LaFerla, Aroa Relano-Gines, Marie-Françoise Chesselet, Nicholas R. Franich, Cynthia Moore, Michael S. Levine, Joan S. Steffan, Leslie M. Thompson

Publikováno v: Reidling, JC; Relaño-Ginés, A; Holley, SM; Ochaba, J; Moore, C; Fury, B; et al.(2018). Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. Stem Cell Reports, 10(1), 58-72. doi: 10.1016/j.stemcr.2017.11.005. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5hr4z9ww
Stem Cell Reports, Vol 10, Iss 1, Pp 58-72 (2018)
Stem Cell Reports

Summary Huntington's disease (HD) is an inherited neurodegenerative disorder with no disease-modifying treatment. Expansion of the glutamine-encoding repeat in the Huntingtin (HTT) gene causes broad effects that are a challenge for single treatment s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345a4660b599a733418cbc09d735bdc6
http://www.escholarship.org/uc/item/5hr4z9ww

Prion replication occurs in endogenous adult neural stem cells and alters their neuronal fate: involvement of endogenous neural stem cells in prion diseases

Autor: Claire Hamela, Carole Crozet, Danielle Casanova, Maxime Belondrade, Chantal Mourton-Gilles, Aroa Relano-Gines, Sylvain Lehmann, Audrey Gabelle

Publikováno v: PLoS Pathogens, Vol 9, Iss 8, p e1003485 (2013)
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2013, 9 (8), pp.e1003485. ⟨10.1371/journal.ppat.1003485⟩
PLoS Pathogens, 2013, 9 (8), pp.e1003485. ⟨10.1371/journal.ppat.1003485⟩

Prion diseases are irreversible progressive neurodegenerative diseases, leading to severe incapacity and death. They are characterized in the brain by prion amyloid deposits, vacuolisation, astrocytosis, neuronal degeneration, and by cognitive, behav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169c31b9dd275d122ae767880af7d6c3
http://europepmc.org/articles/PMC3731238?pdf=render

Gene and cell therapy for prion diseases

Autor: Ollivier Milhavet, Aroa Relano-Gines, Sylvain Lehmann, Carole Crozet, A. Gabelle

Publikováno v: Infectious Disorders-Drug Targets
Infectious Disorders-Drug Targets, Bentham Science Publishers, 2009, 9 (1), pp.58-68. ⟨10.2174/1871526510909010058⟩

Prion diseases are neurodegenerative disorders characterized by the accumulation of an abnormal prion protein named PrP(Sc). PrP(Sc) results from the post-translational conformational modification of the host-encoded protein PrP(C). To date there is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a8df983ce5d56de474e7f0051c7fa9
https://hal.archives-ouvertes.fr/hal-00367789