Zobrazeno 1 - 10 of 115 pro vyhledávání: '"Arnulfo, Mendoza"'
1
Akademický článek
Using the single-cell imaging system and orthotropic footpad injection to establish mouse models for experimental and spontaneous melanoma metastasis
Autor: Yanlin Yu, Arnulfo Mendoza, Glenn Merlino
Publikováno v: STAR Protocols, Vol 4, Iss 3, Pp 102349- (2023)
Summary: Metastasis, a complex process, is responsible for most deaths in patients with cancer. Clinically relevant research models are indispensable to advancing our understanding of metastatic mechanisms and developing new treatments. We here descr
Externí odkaz: https://doaj.org/article/aa666e8ecc314c17b945d9f8d573c108
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2
Akademický článek
PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
Autor: Yanlin Yu, Meng Dai, Liping Huang, Weiping Chen, Ellen Yu, Arnulfo Mendoza, Helen Michael, Chand Khanna, Marcus Bosenberg, Martin McMahon, Glenn Merlino
Publikováno v: iScience, Vol 26, Iss 2, Pp 106070- (2023)
Summary: PTEN encodes a tumor suppressor with lipid and protein phosphatase activities whose dysfunction has been implicated in melanomagenesis; less is known about how its phosphatases regulate melanoma metastasis. We demonstrate that PTEN expressio
Externí odkaz: https://doaj.org/article/28c7c83238b342d5b361be3dd6426e8e
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3
Akademický článek
CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG
Autor: Zhihui Liu, Xiyuan Zhang, Haiyan Lei, Norris Lam, Sakereh Carter, Oliver Yockey, Max Xu, Arnulfo Mendoza, Edjay R. Hernandez, Jun S. Wei, Javed Khan, Marielle E. Yohe, Jack F. Shern, Carol J. Thiele
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Embryonal rhabdomyosarcoma (ERMS) is a childhood cancer with impaired myogenic differentiation despite the presence of myogenic transcription factors. Here, the authors show that CASZ1 directly regulates these myogenic factors and the loss of CASZ1 i
Externí odkaz: https://doaj.org/article/97d6c3168b084c6fbf5af342e06696ec
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7
Akademický článek
The Role of PDGFR-β Activation in Acquired Resistance to IGF-1R Blockade in Preclinical Models of Rhabdomyosarcoma
Autor: Christine M. Heske, Choh Yeung, Arnulfo Mendoza, Joshua T. Baumgart, Leah D. Edessa, Xiaolin Wan, Lee J. Helman
Publikováno v: Translational Oncology, Vol 9, Iss 6, Pp 540-547 (2016)
To determine what alternative pathways may act as mechanisms of bypass resistance to type 1 insulin-like growth factor receptor (IGF-1R) blockade in rhabdomyosarcoma (RMS), we compared expression of receptor tyrosine kinase activity in a number of IG
Externí odkaz: https://doaj.org/article/39d2044f41514d60baf91816e2983a9b
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8
Akademický článek
Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression
Autor: Michael M. Lizardo, James J. Morrow, Tyler E. Miller, Ellen S. Hong, Ling Ren, Arnulfo Mendoza, Charles H. Halsey, Peter C. Scacheri, Lee J. Helman, Chand Khanna
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 11, Pp 699-710 (2016)
Metastasis is the cause of more than 90% of all cancer deaths. Despite this fact, most anticancer therapeutics currently in clinical use have limited efficacy in treating established metastases. Here, we identify the endoplasmic reticulum chaperone p
Externí odkaz: https://doaj.org/article/1cec0555a1e7493ba110c2223f943639
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