T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex

Autor: Arnulf Hertweck, Catherine M. Evans, Malihe Eskandarpour, Jonathan C.H. Lau, Kristine Oleinika, Ian Jackson, Audrey Kelly, John Ambrose, Peter Adamson, David J. Cousins, Paul Lavender, Virginia L. Calder, Graham M. Lord, Richard G. Jenner

Publikováno v: Cell Reports, Vol 15, Iss 12, Pp 2756-2770 (2016)

The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment

Externí odkaz: https://doaj.org/article/62e0042e1c2743aca84f38295c4cab13

microRNAs regulate cell-to-cell variability of endogenous target gene expression in developing mouse thymocytes.

Autor: Rory Blevins, Ludovica Bruno, Thomas Carroll, James Elliott, Antoine Marcais, Christina Loh, Arnulf Hertweck, Azra Krek, Nikolaus Rajewsky, Chang-Zheng Chen, Amanda G Fisher, Matthias Merkenschlager

Publikováno v: PLoS Genetics, Vol 11, Iss 2, p e1005020 (2015)

The development and homeostasis of multicellular organisms relies on gene regulation within individual constituent cells. Gene regulatory circuits that increase the robustness of gene expression frequently incorporate microRNAs as post-transcriptiona

Externí odkaz: https://doaj.org/article/b2c5191d1de54521a5974e37b55f13fc

A population of naive-like CD4(+) T cells stably polarized to the T(H)1 lineage

Autor: Jonathan W. Lo, Maria Vila de Mucha, Stephen Henderson, Luke B. Roberts, Laura E. Constable, Natividad Garrido‐Mesa, Arnulf Hertweck, Emilie Stolarczyk, Emma L. Houlder, Ian Jackson, Andrew S. MacDonald, Nick Powell, Joana F. Neves, Jane K. Howard, Richard G. Jenner, Graham M. Lord

Publikováno v: Lo, J W, de Mucha, M V, Henderson, S, Roberts, L B, Constable, L E, Garrido-Mesa, N, Hertweck, A, Stolarczyk, E, Houlder, E L, Jackson, I, MacDonald, A S, Powell, N, Neves, J F, Howard, J K, Jenner, R G & Lord, G M 2022, ' A population of naive-like CD4+ T cells stably polarized to the TH 1 lineage ', European journal of immunology . https://doi.org/10.1002/eji.202149228

T-bet is the lineage-specifying transcription factor for CD4+ T helper type 1 (TH 1) cells. T-bet has also been found in other CD4+ T cell subsets, including TH 17 cells and Treg, where it modulates their functional characteristics. However, we lack

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe973acb9fd3d5ae69db1113e261d3f
http://hdl.handle.net/10044/1/101802

A Crohn's Disease-associated IL2RA Enhancer Variant Determines the Balance of T Cell Immunity by Regulating Responsiveness to IL-2 Signalling

Autor: Ian Jackson, Graham M. Lord, Jenifer Sanchez, Richard G. Jenner, Omer Serhan Omer, Rimma Goldberg, Luke B. Roberts, Natalie J. Prescott, Jennie Clough, Nedyalko Petrov, Peter M. Irving, Anna Appios, Shahram Kordasti, Miles Parkes, Arnulf Hertweck, Scott David Tasker, Anna Lorenc

Publikováno v: Journal of Crohn's & Colitis

Background and Aims Differential responsiveness to interleukin [IL]-2 between effector CD4+ T cells [Teff] and regulatory T cells [Treg] is a fundamental mechanism of immunoregulation. The single nucleotide polymorphism [SNP] rs61839660, located with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc64403c7a121fe6015b638a389d8d86
https://pubmed.ncbi.nlm.nih.gov/34120187

The Th1 cell regulatory circuitry is largely conserved between human and mouse

Autor: Arnulf Hertweck, Venu Pullabhatla, Stephen Henderson, Graham M. Lord, Richard G. Jenner, Emanuele de Rinaldis, Javier Herrero

Publikováno v: Life science alliance. 4(11)

Gene expression programs controlled by lineage-determining transcription factors are often conserved between species. However, infectious diseases have exerted profound evolutionary pressure, and therefore the genes regulated by immune-specific trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7d236ec1d2556bf7f82a73637c0a79
https://pubmed.ncbi.nlm.nih.gov/34531288