Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains

Autor: Haenig, C., Atias, N., Taylor, A.K., Mazza, A., Schaefer, M.H., Russ, J., Riechers, S.P., Jain, S., Coughlin, M., Fontaine, J.F., Freibaum, B.D., Brusendorf, L., Zenkner, M., Porras, P., Stroedicke, M., Schnoegl, S., Arnsburg, K., Boeddrich, A., Pigazzini, L., Heutink, P., Taylor, J.P., Kirstein, J., Andrade-Navarro, M.A., Sharan, R., Wanker, E.E.

Publikováno v: Cell reports 32(7), 108050-(2020). doi:10.1016/j.celrep.2020.108050

Interactome maps are valuable resources to elucidate protein function and disease mechanisms. Here, we report on an interactome map that focuses on neurodegenerative disease (ND), connects ∼5,000 human proteins via ∼30,000 candidate interactions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7fb105c60f1c4affce2edd06e689d182
https://pubmed.ncbi.nlm.nih.gov/32814053

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Autor: Haenig C; Neuroproteomics, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany., Atias N; School of Computer Science, Tel-Aviv University, Tel-Aviv 69978, Israel., Taylor AK; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA., Mazza A; School of Computer Science, Tel-Aviv University, Tel-Aviv 69978, Israel., Schaefer MH; Division of Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany; Computational Cancer Biology, European Institute of Oncology, 20141 Milano, Italy., Russ J; Neuroproteomics, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany., Riechers SP; Neuroproteomics, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany., Jain S; DZNE Tübingen and Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Coughlin M; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA., Fontaine JF; Division of Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany; Institute of Organismic and Molecular Evolution, Johannes Gutenberg University of Mainz, 55122 Mainz, Germany., Freibaum BD; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA., Brusendorf L; Neuroproteomics, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany., Zenkner M; Neuroproteomics, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany., Porras P; Neuroproteomics, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany; EMBL-EBI, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Stroedicke M; Neuroproteomics, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany., Schnoegl S; Neuroproteomics, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany., Arnsburg K; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) im Forschungsverbund Berlin e.V., 13125 Berlin, Germany., Boeddrich A; Neuroproteomics, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany., Pigazzini L; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) im Forschungsverbund Berlin e.V., 13125 Berlin, Germany., Heutink P; DZNE Tübingen and Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Taylor JP; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA., Kirstein J; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) im Forschungsverbund Berlin e.V., 13125 Berlin, Germany., Andrade-Navarro MA; Division of Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany; Institute of Organismic and Molecular Evolution, Johannes Gutenberg University of Mainz, 55122 Mainz, Germany., Sharan R; School of Computer Science, Tel-Aviv University, Tel-Aviv 69978, Israel. Electronic address: roded@tauex.tau.ac.il., Wanker EE; Neuroproteomics, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany. Electronic address: erich.w@mdc-berlin.de.

Publikováno v: Cell reports [Cell Rep] 2020 Aug 18; Vol. 32 (7), pp. 108050.

HSP110 is a modulator of amyloid beta (Aβ) aggregation and proteotoxicity.

Autor: Montresor S; Department of Cell Biology, University of Bremen, Bremen, Germany., Pigazzini ML; Leibniz Institute for Molecular Pharmacology, Berlin, Germany., Baskaran S; Leibniz Institute on Aging-Fritz-Lipmann-Institute, Jena, Germany., Sleiman M; Department of Cell Biology, University of Bremen, Bremen, Germany.; Leibniz Institute on Aging-Fritz-Lipmann-Institute, Jena, Germany., Adhikari G; Leibniz Institute on Aging-Fritz-Lipmann-Institute, Jena, Germany., Basilicata L; Department of Cell Biology, University of Bremen, Bremen, Germany., Secker L; Department of Cell Biology, University of Bremen, Bremen, Germany., Jacob N; Department of Cell Biology, University of Bremen, Bremen, Germany., Ehlert Y; Department of Cell Biology, University of Bremen, Bremen, Germany., Kelkar A; Department of Cell Biology, University of Bremen, Bremen, Germany., Kalsi GK; Department of Cell Biology, University of Bremen, Bremen, Germany., Kulkarni N; Department of Cell Biology, University of Bremen, Bremen, Germany., Spellerberg P; Department of Cell Biology, University of Bremen, Bremen, Germany., Kirstein J; Leibniz Institute on Aging-Fritz-Lipmann-Institute, Jena, Germany.; Friedrich-Schiller-Universität, Institute for Biochemistry & Biophysics, Jena, Germany.

Publikováno v: Journal of neurochemistry [J Neurochem] 2024 Aug 23. Date of Electronic Publication: 2024 Aug 23.

In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging.

Autor: Kirstein J; Leibniz-Institute for Molecular Pharmacology (FMP), 13125, Berlin, Germany., Arnsburg K; Leibniz-Institute for Molecular Pharmacology (FMP), 13125, Berlin, Germany., Scior A; Leibniz-Institute for Molecular Pharmacology (FMP), 13125, Berlin, Germany., Szlachcic A; Center for Molecular Biology (ZMBH), Heidelberg University, 69120, Heidelberg, Germany., Guilbride DL; Center for Molecular Biology (ZMBH), Heidelberg University, 69120, Heidelberg, Germany., Morimoto RI; Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA., Bukau B; Center for Molecular Biology (ZMBH), Heidelberg University, 69120, Heidelberg, Germany.; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Nillegoda NB; Center for Molecular Biology (ZMBH), Heidelberg University, 69120, Heidelberg, Germany.; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

Publikováno v: Aging cell [Aging Cell] 2017 Dec; Vol. 16 (6), pp. 1414-1424. Date of Electronic Publication: 2017 Oct 10.

Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.

Autor: Desai, Meghal¹ (AUTHOR), Hemant¹ (AUTHOR), Deo, Ankita² (AUTHOR), Naik, Jagyanseni¹ (AUTHOR), Dhamale, Prathamesh¹ (AUTHOR), Kshirsagar, Avinash¹ (AUTHOR), Bose, Tania² (AUTHOR), Majumdar, Amitabha¹ (AUTHOR) amitavamajumdar@gmail.com

Publikováno v: PLoS Biology. 4/22/2024, Vol. 22 Issue 4, p1-38. 38p.