An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses

Autor: McKellar, Joe, Arnaud-Arnould, Mary, Chaloin, Laurent, Tauziet, Marine, Arpin-André, Charlotte, Pourcelot, Oriane, Blaise, Mickaël, Moncorgé, Olivier, Goujon, Caroline

Publikováno v: In Journal of Biological Chemistry January 2023 299(1)

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A genome-wide CRISPR/Cas9 knock-out screen identifies the DEAD box RNA helicase DDX42 as a broad antiviral inhibitor

Autor: Bonaventure, Boris, Rebendenne, Antoine, Garcia de Gracia, Francisco, Tauziet, Marine, McKellar, Joe, Chaves Valadão , Ana Luiza, Courgnaud, Valérie, Bernard, Eric, Briant, Laurence, Gros, Nathalie, Djilli, Wassila, Arnaud-Arnould, Mary, Parrinello, Hugues, Rialle, Stéphanie, Moncorgé, Olivier, Goujon, Caroline

Genome-wide CRISPR/Cas9 knock-out genetic screens are powerful approaches to unravel new regulators of viral infections. With the aim of identifying new cellular inhibitors of HIV-1, we have developed a strategy in which we took advantage of the abil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a6796e61f3ec4dc2a65e4925f7d7f0ad
https://hal.archives-ouvertes.fr/hal-03017363

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Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.

Autor: Rebendenne A; IRIM, CNRS, Montpellier University, France., Roy P; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, USA., Bonaventure B; IRIM, CNRS, Montpellier University, France., Chaves VAL; IRIM, CNRS, Montpellier University, France., Desmarets L; Lille University, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, France., Rouillé Y; Lille University, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, France., Tauziet M; IRIM, CNRS, Montpellier University, France., Arnaud-Arnould M; IRIM, CNRS, Montpellier University, France., Giovannini D; IGMM, CNRS, Montpellier University, France.; Metafora Biosystems, Paris, France., Lee Y; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, USA., DeWeirdt P; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, USA., Hegde M; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, USA., Garcia de GF; IRIM, CNRS, Montpellier University, France., McKellar J; IRIM, CNRS, Montpellier University, France., Wencker M; CIRI, INSERM, CNRS, ENS-Lyon, Lyon University, France., Dubuisson J; Lille University, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, France., Belouzard S; Lille University, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, France., Moncorgé O; IRIM, CNRS, Montpellier University, France., Doench JG; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, USA., Goujon C; IRIM, CNRS, Montpellier University, France.

Publikováno v: Research square [Res Sq] 2021 May 27. Date of Electronic Publication: 2021 May 27.