Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Arnoud H.J. Herremans"'
Autor:
Arnold P. den Hartog, Dijksman Jessica A R, Koos Tipker, Hiskias G. Keizer, Hein K. A. C. Coolen, Henri C. Wals, Tiny J.P. Adolfs, Bob Stork, Peter C Verveer, Andrew C. McCreary, Josephus H. M. Lange, Natasja M J de Jong, Herman H. van Stuivenberg, Jan Hoogendoorn, Chris G. Kruse, Arnoud H.J. Herremans, Eric Ronken, Willem Veerman
Publikováno v:
Journal of Medicinal Chemistry. 47:627-643
A series of novel 3,4-diarylpyrazolines was synthesized and evaluated in cannabinoid (hCB(1) and hCB(2)) receptor assays. The 3,4-diarylpyrazolines elicited potent in vitro CB(1) antagonistic activities and in general exhibited high CB(1) vs CB(2) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bf7d3905b901be5418d4523216fb0d
https://doi.org/10.1021/jm031019q
https://doi.org/10.1021/jm031019q
Autor:
Berend Olivier, Jan Mos, Theo H. Hijzen, Arnoud H.J. Herremans, Ruud van Oorschot, Martin Tulp, Marlies L. Van Drimmelen
Publikováno v:
Pharmacology Biochemistry and Behavior. 64:421-427
Twelve pigeons were successfully (ED 50 = 2.4 mg/kg PO) trained to discriminate the 5-HT 1A/B receptor agonist eltoprazine (5.0 mg/kg PO) from its vehicle in a fixed-ratio (FR)30 two-key operant drug discrimination procedure. Tests for generalization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2557da0af786244723d68e610d099fb
https://doi.org/10.1016/s0091-3057(99)00073-8
https://doi.org/10.1016/s0091-3057(99)00073-8
Publikováno v:
European Journal of Pharmacology. 325:145-153
Twelve homing pigeons were trained to discriminate the 5-HT 1A receptor agonist flesinoxan (0.25 mg/kg p.o.) from its vehicle in a fixed ratio (FR) 30 two-key operant drug discrimination procedure. Tests for generalization and antagonism showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78e4f79f8eb20e2d0febd6433dfd4ae
https://doi.org/10.1016/s0014-2999(97)00131-3
https://doi.org/10.1016/s0014-2999(97)00131-3
Publikováno v:
Brain Research. 711:102-111
Rats trained on a Delayed Matching To Position (DMTP) task displayed mediating behavior during delays to solve the task. Infusion of the cholinergic antagonist scopolamine into the medial Prefrontal Cortex area (mPFC), dose dependently impaired perfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329dfc0e806b16bc823fe8f30b98a4c4
https://doi.org/10.1016/0006-8993(95)01404-7
https://doi.org/10.1016/0006-8993(95)01404-7
Publikováno v:
Journal of psychopharmacology (Oxford, England). 9(3)
We investigated the effects of serotonergic drugs on working memory (WM) in a delayed conditional discrimination task. The 5-HT1A receptor full agonist flesinoxan (0.3-3.0 mg/kg) dose- and delay-dependently impaired performance, indicating a specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192b610ae9f982a08a159a0df64e1fad
https://pubmed.ncbi.nlm.nih.gov/22297764
https://pubmed.ncbi.nlm.nih.gov/22297764
Autor:
Charles R. Ashby, Mayke B. Hesselink, Andrew C. McCreary, Jeffrey C. Glennon, Arnoud H.J. Herremans, Herman H. van Stuivenberg, Jan H. Reinders, Zhu Li, Chris G. Kruse, Long Stephen K, Feenstra Roelof W, Herbert Y. Meltzer
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 32(1)
Combined dopamine D(2) receptor antagonism and serotonin (5-HT)(1A) receptor agonism may improve efficacy and alleviate some side effects associated with classical antipsychotics. The present study describes the in vitro and in vivo characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b78e78b4a166ab2a410a3c6619df4be
https://pubmed.ncbi.nlm.nih.gov/16710314
https://pubmed.ncbi.nlm.nih.gov/16710314
Publikováno v:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 13(5)
Physical (PS) and emotional (ES) stress have opposite long-term effects on open field behaviour, i.e., response to novelty. PS induced a long-term reduction in locomotor activity, while ES increased it. Additionally, sensitivity to rewarding stimuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52f14148f6e75a8e76e38c63e06fcca
https://pubmed.ncbi.nlm.nih.gov/12957336
https://pubmed.ncbi.nlm.nih.gov/12957336
Autor:
Arnoud H.J. Herremans, Theo H. Hijzen
Publikováno v:
Neuroscience and biobehavioral reviews. 21(3)
The validity of delayed-matching-to-sample (DMTS) and related tasks executed in skinner boxes as an animal model for human working memory (WM) is confounded by the occurrence of mediating behaviour during delays. True matching, a supplementary task d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40076de05125aa7aa1cd1fd8248b241
https://pubmed.ncbi.nlm.nih.gov/9168271
https://pubmed.ncbi.nlm.nih.gov/9168271
Publikováno v:
Behavioural brain research. 84(1-2)
Effects of bilateral infusions of cholinergic drugs into the dorsal part of the medial prefrontal cortex (dmPFC) on performance in a delayed conditional discrimination (DCD) task were examined in rats. Scopolamine dose-dependently impaired performanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba16d6d00fd57cb5e7ea24948a129fd8
https://pubmed.ncbi.nlm.nih.gov/9079794
https://pubmed.ncbi.nlm.nih.gov/9079794
Publikováno v:
Journal of neuroscience methods. 63(1-2)
The present study investigated whether changes in response bias (log b) affect discriminability (log d) in a delayed conditional discrimination (DCD) task. Eight rats were trained on an DCD task and response bias was manipulated by changing the reinf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5a44ac8f5dc6f94ca24167cf7ee648
https://pubmed.ncbi.nlm.nih.gov/8788045
https://pubmed.ncbi.nlm.nih.gov/8788045