Mechanism of regulation of pantothenate biosynthesis by the PanD-PanZ.AcCoA complex reveals an additional mode of action for the antimetabolite N-pentyl pantothenamide (N5-Pan)

Autor: Arnott, ZLP, Nozaki, S, Monteiro, DCF, Morgan, HE, Pearson, AR, Niki, H, Webb, ME

The antimetabolite pentyl pantothenamide has broad spectrum antibiotic activity but exhibits enhanced activity against Escherichia coli. The PanDZ complex has been proposed to regulate the pantothenate biosynthetic pathway in E. coli by limiting the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::2dfc20cb770602a4fc9cc585c1200583

Quantitative N- or C-Terminal Labelling of Proteins with Unactivated Peptides by Use of Sortases and a d-Aminopeptidase.

Autor: Arnott ZLP; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.; Present address: Centre for Process Innovation, Central Park, The Nigel Perry Building, 1 Union St, Darlington, DL1 1GL, United Kingdom., Morgan HE; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.; Present Address: Ashfield MedComms, City Tower, Piccadilly Plaza, Manchester, M1 4BT, United Kingdom., Hollingsworth K; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK., Stevenson CME; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK., Collins LJ; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK., Tamasanu A; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK., Machin DC; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK., Dolan JP; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.; Present Address: School of Chemical and Physical Sciences & Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, United Kingdom., Kamiński TP; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK., Wildsmith GC; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK., Williamson DJ; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.; Present Address: Iksuda Therapeutics, The Biosphere, Draymans Way, Newcastle upon Tyne, NE4 5BX, United Kingdom., Pickles IB; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.; Present Address: York Structural Biology Laboratory, Department of Biology, University of York, Heslington, York, YO10 5DD, United Kingdom., Warriner SL; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK., Turnbull WB; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK., Webb ME; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Feb 19; Vol. 63 (8), pp. e202310862. Date of Electronic Publication: 2024 Jan 11.

The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD-PanZ·AcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N-Pentyl Pantothenamide (N5-Pan).

Autor: Arnott ZLP; Astbury Centre for Structural Molecular Biology and School of Chemistry, University of Leeds , Leeds LS2 9JT, U.K.; Hamburg Center for Ultrafast Imaging, Institute of Nanostructure and Solid State Physics, University of Hamburg , Luruper Chaussee 149, Hamburg 22761, Germany., Nozaki S; Microbial Genetics Laboratory, Genetics Strains Research Center, National Institute of Genetics , 1111 Yata, Mishima, Shizuoka 411-8540, Japan., Monteiro DCF; Astbury Centre for Structural Molecular Biology and School of Chemistry, University of Leeds , Leeds LS2 9JT, U.K.; Hamburg Center for Ultrafast Imaging, Institute of Nanostructure and Solid State Physics, University of Hamburg , Luruper Chaussee 149, Hamburg 22761, Germany., Morgan HE; Astbury Centre for Structural Molecular Biology and School of Chemistry, University of Leeds , Leeds LS2 9JT, U.K., Pearson AR; Hamburg Center for Ultrafast Imaging, Institute of Nanostructure and Solid State Physics, University of Hamburg , Luruper Chaussee 149, Hamburg 22761, Germany., Niki H; Microbial Genetics Laboratory, Genetics Strains Research Center, National Institute of Genetics , 1111 Yata, Mishima, Shizuoka 411-8540, Japan.; Department of Genetics, Graduate University for Advanced Studies (Sokendai) , 1111 Yata, Mishima, Shizuoka 411-8540, Japan., Webb ME; Astbury Centre for Structural Molecular Biology and School of Chemistry, University of Leeds , Leeds LS2 9JT, U.K.

Publikováno v: Biochemistry [Biochemistry] 2017 Sep 19; Vol. 56 (37), pp. 4931-4939. Date of Electronic Publication: 2017 Sep 07.