Výsledky vyhledávání - "Arnon ROSENTHAL"

Akademický článek

Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer’s disease

Autor: Hua Long, Adam Simmons, Arthur Mayorga, Brady Burgess, Tuan Nguyen, Balasubrahmanyam Budda, Anna Rychkova, Herve Rhinn, Ilaria Tassi, Michael Ward, Felix Yeh, Tina Schwabe, Robert Paul, Sara Kenkare-Mitra, Arnon Rosenthal

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-19 (2024)

Abstract Background Variants of the gene triggering receptor expressed on myeloid cells-2 (TREM2) increase the risk of Alzheimer’s disease (AD) and other neurodegenerative disorders. Signaling by TREM2, an innate immune receptor expressed by microg

Externí odkaz: https://doaj.org/article/b420255d30c04ee396e2fe0de38486c6

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Akademický článek

Phase 1 study of latozinemab in progranulin‐associated frontotemporal dementia

Autor: Michael Ward, Lawrence P. Carter, Julie Y. Huang, Daniel Maslyar, Balasubrahmanyam Budda, Robert Paul, Arnon Rosenthal

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 1, Pp n/a-n/a (2024)

Abstract INTRODUCTION Heterozygous mutations in the GRN gene lead to reduced progranulin (PGRN) levels in plasma and cerebrospinal fluid (CSF) and are causative of frontotemporal dementia (FTD) with > 90% penetrance. Latozinemab is a human monoclonal

Externí odkaz: https://doaj.org/article/dd511265638b4ca39288d8acd272d8a6

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Akademický článek

Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia

Autor: Michael Kurnellas, Ananya Mitra, Tina Schwabe, Robert Paul, Andrew E. Arrant, Erik D. Roberson, Michael Ward, Felix Yeh, Hua Long, Arnon Rosenthal

Publikováno v: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)

Abstract Background Heterozygous loss-of-function mutations in the progranulin (PGRN) gene (GRN) cause a reduction in PGRN and lead to the development of frontotemporal dementia (FTD-GRN). PGRN is a secreted lysosomal chaperone, immune regulator, and

Externí odkaz: https://doaj.org/article/b2df0fda23a94d45afa816e976160d6e

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Akademický článek

Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration

Autor: Donna M Wilcock, Sanjay K Munireddy, Arnon Rosenthal, Kenneth E Ugen, Marcia N Gordon, Dave Morgan

Publikováno v: Neurobiology of Disease, Vol 15, Iss 1, Pp 11-20 (2004)

The mechanisms by which anti-Aβ antibodies clear amyloid plaques in Aβ depositing transgenic mice are unclear. In the current study, we demonstrate that inhibition of anti-Aβ antibody-induced microglial activation with anti-inflammatory drugs, suc

Externí odkaz: https://doaj.org/article/0288a974cf9849458ec0c52c8975976f

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Akademický článek

Appetite enhancement and weight gain by peripheral administration of TrkB agonists in non-human primates.

Autor: John C Lin, David Tsao, Paul Barras, Raul A Bastarrachea, Bob Boyd, Joyce Chou, Rodnie Rosete, Hua Long, Alison Forgie, Yasmina Abdiche, Jeanette Dilley, Jennifer Stratton, Carlos Garcia, David L Sloane, Anthony G Comuzzie, Arnon Rosenthal

Publikováno v: PLoS ONE, Vol 3, Iss 4, p e1900 (2008)

Loss of function mutations in the receptor tyrosine kinase TrkB pathway resulted in hyperphagia and morbid obesity in human and rodents. Conversely, peripheral or central stimulation of TrkB by its natural ligands BDNF or NT4 reduced body weight and

Externí odkaz: https://doaj.org/article/6efe3da8a10f430793c6095c8907968a

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