Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children

Autor: Amir Ariff, Yong Song, Ruth Aguilar, Augusto Nhabomba, Maria Nelia Manaca, Siew-Kim Khoo, Selma Wiertsema, Quique Bassat, Arnoldo Barbosa, Llorenç Quintó, Ingrid A. Laing, Caterina Guinovart, Pedro L. Alonso, Carlota Dobaño, Peter Le Souëf, Guicheng Zhang

Publikováno v: Malaria Journal, Vol 22, Iss 1, Pp 1-9 (2023)

Abstract Background Malaria is a deadly disease caused by Plasmodium spp. Several blood phenotypes have been associated with malarial resistance, which suggests a genetic component to immune protection. Methods One hundred and eighty-seven single nuc

Externí odkaz: https://doaj.org/article/8cef9e578a3c426dbe18e719a17859cd

High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection

Autor: Carlota Dobaño, Tamara Berthoud, Maria Nelia Manaca, Augusto Nhabomba, Caterina Guinovart, Ruth Aguilar, Arnoldo Barbosa, Penny Groves, Mauricio H. Rodríguez, Alfons Jimenez, Lazaro M. Quimice, John J. Aponte, Jaume Ordi, Denise L. Doolan, Alfredo Mayor, Pedro L. Alonso

Publikováno v: Malaria Journal, Vol 17, Iss 1, Pp 1-13 (2018)

Abstract Background Increased susceptibility to malaria during pregnancy is not completely understood. Cellular immune responses mediate both pathology and immunity but the effector responses involved in these processes have not been fully characteri

Externí odkaz: https://doaj.org/article/6068edda8d864588ba8ef3f5f67f130d

High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection

Autor: Tamara Katherine Berthoud, Carlota Dobaño, Jaume Ordi, Augusto Nhabomba, Arnoldo Barbosa, Ruth Aguilar, Maria N. Manaca, Pedro L. Alonso, John J. Aponte, Denise L. Doolan, Mauricio H. Rodríguez, Alfons Jiménez, Penny Groves, Caterina Guinovart, Alfredo Mayor, Lazaro M. Quimice

Publikováno v: Malaria Journal
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Malaria Journal, Vol 17, Iss 1, Pp 1-13 (2018)

BACKGROUND: Increased susceptibility to malaria during pregnancy is not completely understood. Cellular immune responses mediate both pathology and immunity but the effector responses involved in these processes have not been fully characterized. Mat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755c9320a1a5692476d91a35612a96eb
http://hdl.handle.net/2445/122760

A balanced pro-inflammatory and regulatory cytokine signature in young African children is associated with lower risk of clinical malaria

Autor: Rebeca Santano, Tamara Katherine Berthoud, Alfons Jiménez, Llorenç Quintó, Caterina Guinovart, Pedro L. Alonso, Maria N. Manaca, John J. Aponte, Ruth Aguilar, Arnoldo Barbosa, Carlota Dobaño, Denise L. Doolan, Penny L Groves, Quique Bassat, Augusto Nhabomba, Mauricio H. Rodríguez

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Clin Infect Dis

Background The effect of timing of exposure to first Plasmodium falciparum infections during early childhood on the induction of innate and adaptive cytokine responses and their contribution to the development of clinical malaria immunity is not well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffa4888dce168ace581808079dce8f4
http://hdl.handle.net/2445/128982

Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial

Autor: John J. Aponte, M. Nelia Manaca, Pedro Aide, Inacio Mandomando, Sarah Lafuente, Marc Lievens, Johan Vekemans, Pedro L. Alonso, Joe Cohen, Quique Bassat, Eusebio Macete, Marla Sillman, Marie-Claude Dubois, Betuel Sigaúque, Montse Renom, Amanda J. Leach, Jahit Sacarlal, W. Ripley Ballou, Barbara Savarese, John G McNeil, Marie-Ange Demoitié, Arnoldo Barbosa

Publikováno v: The Lancet. 370:1543-1551

Summary Background Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d84e3bcec31afc1d436685738217e61
https://doi.org/10.1016/s0140-6736(07)61542-6