Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Arnold van Loevezijn"'
Autor:
Josephus H. M. Lange, Remco Henzen, Natasja de Bruin, Jelle de Vries, Wouter I. Iwema Bakker, Wouter de Looff, Arnold P. den Hartog, Stefan Verhoog, Rob P. van de Woestijne, Chris G. Kruse, Arnold van Loevezijn, Jennifer Venhorst, Martina A.W. van der Neut
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1605-1611
The discovery of non-basic N'-(arylsulfonyl)pyrazoline-1-carboxamidines as 5-HT6 antagonists with unique structural features was recently disclosed. Here we describe how this structural class was further developed by addressing an unexplored interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf6abbf2099e90ec1e67445cecda377
https://doi.org/10.1016/j.bmcl.2016.02.001
https://doi.org/10.1016/j.bmcl.2016.02.001
Autor:
Saskia Scheij, Richard J. B. H. N. van den Berg, Wilma E. Donker-Koopman, Mark Leemhuis, Anneke Strijland, Tom Wennekes, Saleem S Butt, Amar B. T. Ghisaidoobe, Gijsbert A. van der Marel, Herman S. Overkleeft, Arnold van Loevezijn, Mario van der Stelt, Constant A. A. van Boeckel, Gerrit-Jan Koomen, Adrianus M. C. H. van den Nieuwendijk, Johannes M. F. G. Aerts
Publikováno v:
Journal of medicinal chemistry, 57(21), 9096-9104. American Chemical Society
This work details the evaluation of a number of N-alkylated deoxynojirimycin derivatives on their merits as dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. Building on our previous work, we synthesized a series of D-gluco and L-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d656b24065d8c0333320542ef08a724f
https://doi.org/10.1021/jm501181z
https://doi.org/10.1021/jm501181z
Autor:
Cor G de Korte, Stefan Verhoog, Martina A.W. van der Neut, Wouter I. Iwema Bakker, Alice J.M. Borst, Jennifer Venhorst, Chris G. Kruse, Natasja de Bruin, Rob P. van de Woestijne, Hiskias G. Keizer, Arnold van Loevezijn, Wouter de Looff, Jan-Willem van Wees, Maria J.P. van Dongen, Martijn van Hoeve
Publikováno v:
Journal of Medicinal Chemistry. 54:7030-7054
The 5-HT(6) receptor (5-HT(6)R) has been in the spotlight for several years regarding CNS-related diseases. We set out to discover novel, neutral 5-HT(6)R antagonists to improve off-target selectivity compared to basic amine-containing scaffolds domi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01b80e49fd141f75bc4e9afb4ff68b46
https://doi.org/10.1021/jm200466r
https://doi.org/10.1021/jm200466r
Publikováno v:
Tetrahedron Letters. 52:3198-3200
An expedient one-pot procedure for the atom-efficient production of a variety of sulfonylguanidines and sulfamoylguanidines under mild conditions is described. The route constitutes an important alternative to current methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f6fdd55c9fc9db0a7db044ad977d393
https://doi.org/10.1016/j.tetlet.2011.04.031
https://doi.org/10.1016/j.tetlet.2011.04.031
Publikováno v:
Tetrahedron Letters. 39:4737-4740
A solid phase synthesis towards structural analogs of fumitremorgins, verruculogens and tryprostatins using a cyclization/cleavage strategy was developed. To grove the general applicability of the route, a representative set of 42 single compounds (a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e66786fd71c8d971985e74338a2e0b88
https://doi.org/10.1016/s0040-4039(98)00931-9
https://doi.org/10.1016/s0040-4039(98)00931-9
Autor:
Arnold, van Loevezijn, Jennifer, Venhorst, Wouter I, Iwema Bakker, Cor G, de Korte, Wouter, de Looff, Stefan, Verhoog, Jan-Willem, van Wees, Martijn, van Hoeve, Rob P, van de Woestijne, Martina A W, van der Neut, Alice J M, Borst, Maria J P, van Dongen, Natasja M W J, de Bruin, Hiskias G, Keizer, Chris G, Kruse
Publikováno v:
Journal of medicinal chemistry. 54(20)
The 5-HT(6) receptor (5-HT(6)R) has been in the spotlight for several years regarding CNS-related diseases. We set out to discover novel, neutral 5-HT(6)R antagonists to improve off-target selectivity compared to basic amine-containing scaffolds domi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75ef008ee0bc37511a8ca06420a5a337
https://pubmed.ncbi.nlm.nih.gov/21866910
https://pubmed.ncbi.nlm.nih.gov/21866910
Publikováno v:
ChemInform. 42
The described synthetic methodology exhibits a broad application, but sterically demanding amines, such as (IIg), appear to limit the scope.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bcc476fcbb464023e38b0039a2bdf16
https://doi.org/10.1002/chin.201138060
https://doi.org/10.1002/chin.201138060
Autor:
Chris G. Kruse, Bart J. van Steen, Leo A. J. M. Sliedregt, Arnold van Loevezijn, Leon W. A. van Berkom, Floris P. J. T. Rutjes, Hans W. Scheeren, Mohamed Kalmoua, George J. T. Kuster
Publikováno v:
Journal of Combinatorial Chemistry, 8, 85-94
Journal of Combinatorial Chemistry, 8, 1, pp. 85-94
Journal of Combinatorial Chemistry, 8, 1, pp. 85-94
A seven-step solid-phase synthesis of spirohydantoins and an eight-step solid-phase synthesis of spiro-2,5-diketopiperazines is reported. Key intermediate in the synthesis of both compound libraries is the resin-bound cyclic alpha,alpha-disubstituted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ae966c4da6ebb1474ea469a7c7c207
http://hdl.handle.net/2066/33042
http://hdl.handle.net/2066/33042
Autor:
Marjolein A, van der Pol, Henk J, Broxterman, Jennie M, Pater, Nicole, Feller, Martin, van der Maas, Geert W D, Weijers, George L, Scheffer, John D, Allen, Rik J, Scheper, Arnold, van Loevezijn, Gert J, Ossenkoppele, Gerrit J, Schuurhuis
Publikováno v:
Haematologica. 88(2)
Relapse is common in acute myeloid leukemia (AML) because of persistence of minimal residual disease (MRD). ABC-transporters P-glycoprotein (Pgp) and multidrug resistance protein (MRP), are thought to contribute to treatment failure, while it is unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aded2dba64589f9638d6ea4d4c5910aa
https://pubmed.ncbi.nlm.nih.gov/12604403
https://pubmed.ncbi.nlm.nih.gov/12604403
Autor:
John D, Allen, Arnold, van Loevezijn, Jeany M, Lakhai, Martin, van der Valk, Olaf, van Tellingen, Glen, Reid, Jan H M, Schellens, Gerrit-Jan, Koomen, Alfred H, Schinkel
Publikováno v:
Molecular cancer therapeutics. 1(6)
Inhibitors of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter are of interest as chemosensitizers for clinical drug resistance, for improving the pharmacokinetics of substrate chemotherapeutic drugs, and in functional assays o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::940bcf51afd7217c49ca149405c651f0
https://pubmed.ncbi.nlm.nih.gov/12477054
https://pubmed.ncbi.nlm.nih.gov/12477054